Cited by 138Vagus Nerve Stimulation ResearchDeep Brain Stimulation and Movement DisordersElectroconvulsive Therapy Studies

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Vagus nerve stimulation in psychiatry: a systematic review of the available evidence

Cimpianu, Camelia-Lucia, Strube, Wolfgang, Falkai, Peter, Palm, Ulrich, Hasan, Alkomiet·2017·Journal of Neural Transmission

DOI 10.1007/s00702-016-1642-2

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Abstract

Invasive and non-invasive vagus nerve stimulation (VNS) is a promising add-on treatment for treatment-refractory depression, but is also increasingly evaluated for its application in other psychiatric disorders, such as dementia, schizophrenia, somatoform disorder, and others. We performed a systematic review aiming to give a detailed overview of the available evidence of the efficacy of VNS for the treatment of psychiatric disorders. Data derived from animal models, experimental trials without health-related outcomes, case reports, single-session studies, and reviews were excluded. From 1292 publications, 33 records were included for further analyses: 25 focused on VNS as treatment of unipolar or bipolar major depressive disorder and one investigated the neurocognitive improvement after VNS in major depressive disorder. Seven focused on the improvement of cognitive function in Alzheimer´s disease, improvement of schizophrenia symptoms, treatment of obsessive compulsive disorder (OCD), panic disorder (PD) and post-traumatic stress disorder (PTSD), treatment resistant rapid-cycling bipolar disorder, treatment of fibromyalgia, and Prader-Willi syndrome. A total of 29 studies used invasive VNS, while four studies used non-invasive, transcutaneous VNS. Only 7 out of 33 studies investigated conditions other than affective disorders. The efficacy data of VNS in affective disorders is promising, whereas more in controlled and naturalistic studies are needed. In other conditions like schizophrenia, Alzheimer's disease, OCD, PD, PTSD, and fibromyalgia, either no effects or preliminary data on efficacy were reported. At this point, no final conclusion can be made regarding the efficacy of VNS to improve symptoms in psychiatric disorders other than in affective disorders.

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Rush AJ, Marangell LB, Sackeim HA, George MS, Brannan SK, Davis SM, Howland R, Kling MA, Rittberg BR, Burke WJ, Rapaport MH, Zajecka J, Nierenberg AA, Husain MM, Ginsberg D, Cooke RG (2005a) Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial. Biol Psychiatry 58(5):347–354. doi: 10.1016/j.biopsych.2005.05.025 · DOI · Paper page

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Authors: Cimpianu, C.-L., Strube, W., Falkai, P., Palm, U., & Hasan, A.
Affiliations: Klinik und Poliklinik für Psychiatrie und Psychotherapie (DE)
Ludwig-Maximilians-Universität München (DE)
Corresponding author: Cimpianu, Camelia-Lucia
ORCID: Strube, Wolfgang
Falkai, Peter
Palm, Ulrich
Hasan, Alkomiet
Venue: Journal of Neural Transmission
Publisher: Springer Science and Business Media LLC
Published: 2016-11-16
Volume: 124
Issue: 1
Pages: 145-158
ISSN: 0300-9564 (ISSN-L)
1435-1463
DOI: 10.1007/s00702-016-1642-2
OpenAlex: W2551129515
Cited by: 138
References: 65
Citations by year: 2026: 6 · 2025: 13 · 2024: 20 · 2023: 14 · 2022: 13 · 2021: 14 · 2020: 17 · 2019: 12 · 2018: 15 · 2017: 14
FWCI: 1.20
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Journal of Neural Transmission (publishedVersion)
PubMed (publishedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
OPUS (Augsburg University) (submittedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
Keywords: vagus nerve stimulation, treatment-resistant depression, bipolar disorder, Alzheimer's disease, schizophrenia, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, fibromyalgia, Prader-Willi syndrome, transcutaneous vagus nerve stimulation, cognitive function, mental illness
MeSH terms: Mental Disorders, Humans, Psychiatry, Evidence-Based Medicine, Vagus Nerve Stimulation

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Vagus nerve stimulation in psychiatry: a systematic review of the available evidence

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