Parasympathetic activity as a potential biomarker of negative symptoms in patients with schizophrenia
Abstract
Introduction: Autonomic dysfunction in patients with schizophrenia has raised concern considering the higher cardiovascular mortality and morbidity rate. This phenomenon has been demonstrated using various measurements and is inferred to be associated with demographics, medical treatment, and psychopathology. However, few have targeted the role of negative symptoms within schizophrenia. Methods: Schizophrenia patients with stationary psychopathology were recruited from a chronic ward, a daycare center, and a nonintensive case management program. Demographic data, medication history, the Positive and Negative Syndrome Scale (PANSS) score, the Personal and Social Performance Scale (PSP) score, and the five‐minute resting‐state heart rate variability (HRV) were collected at trial initiation (Time 1) and a year later (Time 2). The relationships between variables and HRV indices were evaluated using correlation and regression analyses. Results: A total of 63 participants were recruited at Time 1, with 29 participants remaining at Time 2. Correlation analyses showed a negative correlation between the PANSS negative score (PANSS‐N) and total power (TP), low‐frequency power (LF), and high‐frequency power (HF) at Time 1. The results were further examined with multiple linear regression analysis and remained significant between the PANSS‐N score and HF (β = −0.306, P = .012). A generalized estimating equation model revealed the above negative association to be significant considering both timepoints. Discussion: The negative association between negative symptom severity and parasympathetic activity was significant, which may inspire further research into the corresponding treatment, the mechanisms, and the use of HRV as an applicable biomarker for treatment response.
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The negative symptom domain of the PANSS is inversely related to parasympathetic HRV parameters RMSSD and HF and positively associated with the LF/HF ratio.
“Elsewhere, the negative symptom domain of the PANSS, which focuses largely on distortions in emotional, social and thinking processes, was inversely related to parasympathetic HRV parameters RMSSD34 and HF28,34,61 and positively associated with the LF/HF ratio34;”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [61]
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Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health
Stogios, N., Gdanski, A., Gerretsen, P., Chintoh, A. F., Graff-Guerrero, A., Rajji, T. K., Remington, G., Hahn, M. K., & Agarwal, S. M. (2021) · npj Schizophrenia · doi:10.1038/s41537-021-00151-6 · Cited by 98 · see citing works
“For example, Huang et al.61 have suggested that the use of HRV may be an applicable biomarker for treatment response on negative symptoms, given the well-reported inverse association between HRV and negative symptom severity, as well as a screening tool for cardiovascular risk stratification and early intervention.”
Background
- Authors
- Huang, W., Liu, W., Chen, T., Chen, W., & Huang, W.
- Affiliations
- National Taiwan University (TW)
- National Taiwan University Hospital (TW)
- Department of Psychiatry National Taiwan University Hospital, Yun‐Lin Branch Yunlin Taiwan
- Department of Psychiatry National Taiwan University Hospital Taipei Taiwan
- Corresponding author
- Huang, Wei‐Lieh
- ORCID
- Huang, Wei‐Lieh
- Venue
- Asia-Pacific Psychiatry
- Publisher
- Wiley
- Published
- 2020-05-26
- Volume
- 12
- Issue
- 3
- Pages
- e12392-e12392
- ISSN
- 1758-5864 (ISSN-L)
- 1758-5872
- OpenAlex
- W3031207315
- Cited by
- 10
- References
- 81
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Asia-Pacific Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Taiwan University Hospital, Yun-Lin Branch (NTUHYL105.X002)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- schizophrenia, negative symptoms, parasympathetic activity, heart rate variability, autonomic dysfunction, biomarkers, treatment response, PANSS, Personal and Social Performance Scale, chronic schizophrenia
- MeSH terms
- Adult, Female, Heart Rate, Humans, Male, Middle Aged, Parasympathetic Nervous System, Schizophrenia, Severity of Illness Index, Biomarkers
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