Cited by 460Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsDrug Solubulity and Delivery Systems

Development of Biodegradable Nanoparticles for Delivery of Quercetin

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Kumari, Avnesh, Yadav, Sudesh Kumar, Pakade, Yogesh B., Singh, Bikram, Yadav, Subhash Chandra·2010·Colloids and Surfaces B Biointerfaces

Abstract

The antioxidant molecule quercetin has been encapsulated on poly-D,L-lactide (PLA) nanoparticles by solvent evaporation method for the improvement of its poor aqueous solubility and stability. The surface morphology and average size of PLA and quercetin loaded PLA nanoparticles are 170+/-25 and 130+/-30 nm respectively. The antioxidant activities of the PLA encapsulated quercetin nanomedicine are identical to free quercetin. The nanoencapsulation efficiency of quercetin evaluated by HPLC and antioxidant assay is 96.7%. The in vitro release kinetics under physiological condition show initial burst release followed by slow and sustained release. The complete release and maximum retention of quercetin is 72 and 96h respectively. The less fluorescence quenching efficiency of quercetin-PLA nanoparticles than free quercetin on BSA confirms the controlled release of quercetin from PLA nanoparticles. These properties of PLA encapsulated quercetin molecule pave way for encapsulating various therapeutically less useful highly active antioxidant molecules towards the development of better therapeutic compounds.

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Crossref · 10.1016/j.colsurfb.2010.06.002

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Authors
Kumari, A., Yadav, S. K., Pakade, Y. B., Singh, B., & Yadav, S. C.
Affiliations
Institute of Himalayan Bioresource Technology (IN)
Corresponding author
  • Yadav, Sudesh Kumar
  • Yadav, Subhash Chandra
Venue
Colloids and Surfaces B Biointerfaces
Publisher
Elsevier BV
Published
2010-10
Volume
80
Issue
2
Pages
184-192
ISSN
0927-7765 (ISSN-L)
OpenAlex
W2047271327
Cited by
460
References
28
Citations by year
2026: 14 · 2025: 26 · 2024: 27 · 2023: 33 · 2022: 43 · 2021: 37 · 2020: 47 · 2019: 34 · 2018: 36 · 2017: 29 · 2016: 34 · 2015: 28 · 2014: 24 · 2013: 18 · 2012: 16
FWCI
6.34
Type
journal article
Language
en
Open access
Locations
  • Colloids and Surfaces B Biointerfaces (publishedVersion)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords
quercetin, biodegradable nanoparticles, nanoencapsulation, antioxidant activity, aqueous solubility enhancement, sustained drug release, fluorescence quenching, encapsulation efficiency, nanomedicine, solvent evaporation
MeSH terms
Antioxidants, Biocompatible Materials, Chromatography, High Pressure Liquid, Drug Carriers, Polyesters, Quercetin, Spectroscopy, Fourier Transform Infrared, Microscopy, Atomic Force, Nanoparticles

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