Development of Biodegradable Nanoparticles for Delivery of Quercetin
Open accessAbstract
The antioxidant molecule quercetin has been encapsulated on poly-D,L-lactide (PLA) nanoparticles by solvent evaporation method for the improvement of its poor aqueous solubility and stability. The surface morphology and average size of PLA and quercetin loaded PLA nanoparticles are 170+/-25 and 130+/-30 nm respectively. The antioxidant activities of the PLA encapsulated quercetin nanomedicine are identical to free quercetin. The nanoencapsulation efficiency of quercetin evaluated by HPLC and antioxidant assay is 96.7%. The in vitro release kinetics under physiological condition show initial burst release followed by slow and sustained release. The complete release and maximum retention of quercetin is 72 and 96h respectively. The less fluorescence quenching efficiency of quercetin-PLA nanoparticles than free quercetin on BSA confirms the controlled release of quercetin from PLA nanoparticles. These properties of PLA encapsulated quercetin molecule pave way for encapsulating various therapeutically less useful highly active antioxidant molecules towards the development of better therapeutic compounds.
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Nanotechnology may significantly improve brain delivery of quercetin and enhance its bioavailability.
“several studies using multiple nanoparticles formulations have shown that the use of nanotechnology may significantly improve the brain delivery of quercetin and enhance its bioavailability (Kumari et al., 2010; Bagad and Khan, 2015; Najafabadi et al., 2018)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Kumari et al., 2010
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- Authors
- Kumari, A., Yadav, S. K., Pakade, Y. B., Singh, B., & Yadav, S. C.
- Affiliations
- Institute of Himalayan Bioresource Technology (IN)
- Corresponding author
- Yadav, Sudesh Kumar
- Yadav, Subhash Chandra
- Venue
- Colloids and Surfaces B Biointerfaces
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 80
- Issue
- 2
- Pages
- 184-192
- ISSN
- 0927-7765 (ISSN-L)
- OpenAlex
- W2047271327
- Cited by
- 460
- References
- 28
- Citations by year
- 2026: 14 · 2025: 26 · 2024: 27 · 2023: 33 · 2022: 43 · 2021: 37 · 2020: 47 · 2019: 34 · 2018: 36 · 2017: 29 · 2016: 34 · 2015: 28 · 2014: 24 · 2013: 18 · 2012: 16
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- Locations
- Colloids and Surfaces B Biointerfaces (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- quercetin, biodegradable nanoparticles, nanoencapsulation, antioxidant activity, aqueous solubility enhancement, sustained drug release, fluorescence quenching, encapsulation efficiency, nanomedicine, solvent evaporation
- MeSH terms
- Antioxidants, Biocompatible Materials, Chromatography, High Pressure Liquid, Drug Carriers, Polyesters, Quercetin, Spectroscopy, Fourier Transform Infrared, Microscopy, Atomic Force, Nanoparticles
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