Cited by 64Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

CCK and NPY as anti-anxiety treatment targets: promises, pitfalls, and strategies

Harro, J.·2006·Amino Acids

Abstract

Short CCK peptides elicit panic attacks in humans and anxiogenic-like effects in some animal models, but CCK receptor antagonists have not been found clinically effective. Yet CCK overactivity appears to be involved in submissive behaviour, and CCKB receptor expression and binding are increased in suicide victims and animal models of anxiety. Preliminary data suggest that involvement of CCK and its receptor subtypes in anxiety can be better described when focusing on distinct endophenotypes, and considering environmental contingencies and confounds originating from interactions with dopamin-, opioid- and glutamatergic neurotransmission. In contrast, NPY is an anti-anxiety peptide with robust effects in various animal models when administrated into several brain regions. Studies with non-peptide antagonists selective for receptor subtypes have revealed the role of endogenous NPY in active coping. At least Y1, Y2 and Y5 receptors in various brain regions are involved, with the strongest evidence for contribution of Y1.

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Crossref · 10.1007/s00726-006-0334-x

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Authors
Harro, J.
Affiliations
University of Tartu (EE)
Corresponding author
Harro, J.
Venue
Amino Acids
Published
2006-06-01
Volume
31
Issue
3
Pages
215-230
ISSN
  • 0939-4451 (ISSN-L)
  • 1438-2199
OpenAlex
W2003648621
Cited by
64
References
144
Citations by year
2026: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 5 · 2013: 4 · 2012: 2
FWCI
0.52
Type
journal article
Language
en
Open access
closed
Locations
  • Amino Acids (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
cholecystokinin, neuropeptide Y, anxiety, CCK receptor antagonists, CCK-B receptor, Y1 receptor, Y2 receptor, Y5 receptor, panic attacks, submissiveness, suicide, endophenotypes, dopamine signaling, glutamatergic neurotransmission, active coping
MeSH terms
Animals, Anxiety Disorders, Brain, Cholecystokinin, gamma-Aminobutyric Acid, Humans, Neuropeptide Y, Receptors, Cholecystokinin, Anti-Anxiety Agents, Receptors, Neuropeptide Y

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