Enteroendocrine hormones – central effects on behavior
Open accessAbstract
A number of appetite-regulating gut hormones alter behaviors linked to reward, anxiety/mood, memory and cognitive function, although for some of these (notably GLP-1 and CCK) the endogenous signal may be CNS-derived. From a physiological perspective it seems likely that these hormones, whose secretion is altered by nutritional status and by bariatric weight loss surgery, orchestrate neurobiological effects that are integrated and linked to feeding/metabolic control. Consistent with a role in hunger and meal initiation, ghrelin increases motivated behavior for food and, when food is not readily available, decreases behaviors in anxiety tests that would otherwise hinder the animal from finding food. Of the many anorexigenic signals, GLP-1 and PYY have been linked to a suppressed reward function and CCK (and possibly GLP-1) to increased anxiety-like behavior.
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There is substantial evidence that elevated levels of CCK induce feelings of anxiety.
“There is also substantial evidence that elevated levels of CCK induce feelings of anxiety (49).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [49]
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- Egecioglu E, Jerlhag E, Salome N, Skibicka KP, Haage D, Bohlooly YM, Andersson D, Bjursell M, Perrissoud D, Engel JA et al.: Ghrelin increases intake of rewarding food in rodents. Addict Biol 2010, 15:304-311.
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Self-citation
- Authors
- Skibicka, K. P., & Dickson, S. L.
- Affiliations
- University of Gothenburg (SE)
- Corresponding author
- Dickson, Suzanne L
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 13
- Issue
- 6
- Pages
- 977-982
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W2064185036
- Cited by
- 69
- References
- 70
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 13 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 1
- FWCI
- 0.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Opinion in Pharmacology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Swedish Research Council for Medicine (2011-3054, 2012-1758)
- European Commission Seventh Framework (FP7-KBBE-2010-4-266408, FP7-HEALTH-2009-241592, FP7-KBBE-2009-3-245009)
- Forskning och Utvecklingsarbete/Avtal om Läkarutbildning och Forskning Göteborg (ALFGBG-138741)
- Swedish Foundation for Strategic Research (A305-188)
- NovoNordisk Fonden
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- enteroendocrine hormones, gastrointestinal hormones, appetite regulation, ghrelin, glucagon-like peptide-1, cholecystokinin, peptide YY, reward behavior, anxiety-like behavior, mood, bariatric surgery, nutritional status, feeding behavior, food motivation
- MeSH terms
- Animals, Behavior, Eating, Gastrointestinal Hormones, Humans, Enteroendocrine Cells
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