The DOI matches its Crossref record; 273 of the 274 references it cites were found in a registry or an index.
Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences
Abstract
Depending on the amount of alimentary proteins, between 6 and 18 g nitrogenous material per day enter the large intestine lumen through the ileocaecal junction. This material is used as substrates by the flora resulting eventually in the presence of a complex mixture of metabolites including ammonia, hydrogen sulfide, short and branched-chain fatty acids, amines; phenolic, indolic and N-nitroso compounds. The beneficial versus deleterious effects of these compounds on the colonic epithelium depend on parameters such as their luminal concentrations, the duration of the colonic stasis, the detoxication capacity of epithelial cells in response to increase of metabolite concentrations, the cellular metabolic utilization of these metabolites as well as their effects on colonocyte intermediary and oxidative metabolism. Furthermore, the effects of metabolites on electrolyte movements through the colonic epithelium must as well be taken into consideration for such an evaluation. The situation is further complicated by the fact that other non-nitrogenous compounds are believed to interfere with these various phenomenons. Finally, the pathological consequences of the presence of excessive concentrations of these compounds are related to the short- and, most important, long-term effects of these compounds on the rapid colonic epithelium renewing and homeostasis.
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“Microbial-derived BCAAs include valerate, isobutyrate, and isovalerate.Notably, these bacterial metabolites have been shown to influence epithelial physiology and the mucosal immune system of the host (Blachier et al., 2007;Schaible and Kaufmann, 2005).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Blachier et al., 2007
In the citing paper
“Most of host-produced urea is hydrolyzed in the lumen of the large intestine into NH3 and nitrogen through bacterial urease activity [131].”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [131]
In the citing paper
“NH3 can be used by the bacteria for their own metabolism and protein synthesis [131].”
From Exercise-induced stress behavior, gut-microbiota-brain axis and diet: a systematic review for athletes (2016) · cites this paper as [131]
In the citing paper
“The GM produces higher proportions of specific BCAAs (valerate, isobutyrate, and isovalerate) relative to other amino acids, which have been shown to influence epithelial and mucosal homeostasis (332).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [332]
In the citing paper
“The GM produces higher proportions of specific BCAAs (valerate, isobutyrate, and isovalerate) relative to other amino acids, which have been shown to influence epithelial and mucosal homeostasis (332).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [332]
In the citing paper
“Microbial-derived BCFAs, isovalerate, and isobutyrate have been linked to epithelial physiology and the mucosal immune system (380, 382, 383).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [382]
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Amino acids: Metabolism, functions, and nutrition
Wu, G. (2009) · Amino Acids · doi:10.1007/s00726-009-0269-0 · Cited by 3,004
Short-chain fatty acids in control of body weight and insulin sensitivity
Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.128 · Cited by 2,298
Chemical transformation of xenobiotics by the human gut microbiota
Koppel, N., Maini Rekdal, V., & Balskus, E. P. (2017) · Science · doi:10.1126/science.aag2770 · Cited by 1,080
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Metadata
- Authors
- Blachier, F., Mariotti, F., Huneau, J. F., & Tomé, D.
- Affiliations
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
- Physiologie de la Nutrition et du Comportement Alimentaire (FR)
- Venue
- Amino Acids
- Published
- 2006-12-06
- Volume
- 33
- Issue
- 4
- Pages
- 547-562
- ISSN
- 0939-4451 (ISSN-L)
- 1438-2199
- OpenAlex
- W1975034176
- Semantic Scholar
- 378e65004ac0b84d7d32fddc40404dfde955ba9e
- Cited by
- 452
- References
- 274
- Citations by year
- 2026: 19 · 2025: 25 · 2024: 43 · 2023: 35 · 2022: 41 · 2021: 34 · 2020: 32 · 2019: 36 · 2018: 36 · 2017: 21 · 2016: 18 · 2015: 27 · 2014: 11 · 2013: 12 · 2012: 17
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Amino Acids (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Keywords
- colonic epithelium, colonic microbiota, ammonia, hydrogen sulfide, short-chain fatty acids, branched-chain fatty acids, amines, phenolic compounds, N-nitroso compounds, colonic stasis, oxidative metabolism, electrolyte transport, colonic homeostasis, colon carcinogenesis
- MeSH terms
- Amino Acids, Ammonia, Animals, Bacteria, Colon, Colonic Diseases, Dietary Proteins, Digestion, Epithelial Cells, Fatty Acids, Humans, Hydrogen Sulfide, Intestinal Mucosa, Intestine, Large, Nitroso Compounds, Polyamines, Hydroxybenzoates
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