Cited by 452Gut microbiota and healthAnimal Nutrition and PhysiologyPolyamine Metabolism and Applications

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Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences

Blachier, F., Mariotti, F., Huneau, J. F., Tomé, D.·2007·Amino Acids

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Abstract

Depending on the amount of alimentary proteins, between 6 and 18 g nitrogenous material per day enter the large intestine lumen through the ileocaecal junction. This material is used as substrates by the flora resulting eventually in the presence of a complex mixture of metabolites including ammonia, hydrogen sulfide, short and branched-chain fatty acids, amines; phenolic, indolic and N-nitroso compounds. The beneficial versus deleterious effects of these compounds on the colonic epithelium depend on parameters such as their luminal concentrations, the duration of the colonic stasis, the detoxication capacity of epithelial cells in response to increase of metabolite concentrations, the cellular metabolic utilization of these metabolites as well as their effects on colonocyte intermediary and oxidative metabolism. Furthermore, the effects of metabolites on electrolyte movements through the colonic epithelium must as well be taken into consideration for such an evaluation. The situation is further complicated by the fact that other non-nitrogenous compounds are believed to interfere with these various phenomenons. Finally, the pathological consequences of the presence of excessive concentrations of these compounds are related to the short- and, most important, long-term effects of these compounds on the rapid colonic epithelium renewing and homeostasis.

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See all 452

Authors: Blachier, F., Mariotti, F., Huneau, J. F., & Tomé, D.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Physiologie de la Nutrition et du Comportement Alimentaire (FR)
ORCID: Blachier, F.
Mariotti, F.
Huneau, J. F.
Tomé, D.
Venue: Amino Acids
Publisher: Springer Science and Business Media LLC
Published: 2006-12-06
Volume: 33
Issue: 4
Pages: 547-562
ISSN: 0939-4451 (ISSN-L)
1438-2199
DOI: 10.1007/s00726-006-0477-9
OpenAlex: W1975034176
Semantic Scholar: 378e65004ac0b84d7d32fddc40404dfde955ba9e
Cited by: 452
References: 274
Citations by year: 2026: 19 · 2025: 25 · 2024: 43 · 2023: 35 · 2022: 41 · 2021: 34 · 2020: 32 · 2019: 36 · 2018: 36 · 2017: 21 · 2016: 18 · 2015: 27 · 2014: 11 · 2013: 12 · 2012: 17
FWCI: 0.48
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Amino Acids (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
Keywords: colonic epithelium, colonic microbiota, ammonia, hydrogen sulfide, short-chain fatty acids, branched-chain fatty acids, amines, phenolic compounds, N-nitroso compounds, colonic stasis, oxidative metabolism, electrolyte transport, colonic homeostasis, colon carcinogenesis
MeSH terms: Amino Acids, Ammonia, Animals, Bacteria, Colon, Colonic Diseases, Dietary Proteins, Digestion, Epithelial Cells, Fatty Acids, Humans, Hydrogen Sulfide, Intestinal Mucosa, Intestine, Large, Nitroso Compounds, Polyamines, Hydroxybenzoates

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Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences

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