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Cited by 233Gut microbiota and healthAnimal Nutrition and PhysiologyAmino Acid Enzymes and Metabolism

Re-print of “Intestinal luminal nitrogen metabolism: Role of the gut microbiota and consequences for the host”

Open access
Davila, Anne-Marie, Blachier, François, Gotteland, Martin, Andriamihaja, Mireille, Benetti, Pierre-Henri, Sanz, Yolanda, Tomé, Daniel·2013·Pharmacological Research
DOI 10.1016/j.phrs.2013.01.003
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Abstract

Alimentary and endogenous proteins are mixed in the small intestinal lumen with the microbiota. Although experimental evidences suggest that the intestinal microbiota is able to incorporate and degrade some of the available amino acids, it appears that the microbiota is also able to synthesize amino acids raising the view that amino acid exchange between the microbiota and host can proceed in both directions. Although the net result of such exchanges remains to be determined, it is likely that a significant part of the amino acids recovered from the alimentary proteins are used by the microbiota. In the large intestine, where the density of bacteria is much higher than in the small intestine and the transit time much longer, the residual undigested luminal proteins and peptides can be degraded in amino acids by the microbiota. These amino acids cannot be absorbed to a significant extent by the colonic epithelium, but are precursors for the synthesis of numerous metabolic end products in reactions made by the microbiota. Among these products, some like short-chain fatty acids and organic acids are energy substrates for the colonic mucosa and several peripheral tissues while others like sulfide and ammonia can affect the energy metabolism of colonic epithelial cells. More work is needed to clarify the overall effects of the intestinal microbiota on nitrogenous compound metabolism and consequences on gut and more generally host health.

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Crossref · 10.1016/j.phrs.2013.01.003

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180 of 180 references verified0 citation errors · 0 not checkable

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  • In the large intestine, the gut microbiota can break down proteins to use as nitrogen sources to support their growth.

    “Moreover, in the large intestine, the gut microbiota can also break down proteins to use as nitrogen sources to support their growth [17].”

    From Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization (2023) · cites this paper as [17]

  • Some taxa within the intestinal microbiota possess enzymatic capacity to degrade dietary protein, which could play especially important roles in protein-rich, low-fiber diets where microbial energy harvest shifts from carbohydrate to protein sources.

    “Some taxa within the intestinal microbiota possess the enzymatic capacity (i.e., proteases) to degrade dietary protein (e.g., Bacteroides, Clostridium, Fusobacterium, Streptococcus), which could play especially important roles in protein-rich, low-fiber diets, in which microbial energy harvest shifts from carbohydrate to protein sources (373, 374).”

    From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [374]

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Authors
Davila, A.-M., Blachier, F., Gotteland, M., Andriamihaja, M., Benetti, P.-H., Sanz, Y., & Tomé, D.
Affiliations
  • AgroParisTech (FR)
  • Instituto de Agroquímica y Tecnología de Alimentos (ES)
Corresponding author
Davila, Anne-Marie
ORCID
Venue
Pharmacological Research
Publisher
Elsevier BV
Published
2013-03
Volume
69
Issue
1
Pages
114-126
ISSN
1043-6618 (ISSN-L)
DOI
10.1016/j.phrs.2013.01.003
OpenAlex
W2084796563
Cited by
231
References
182
Citations by year
2026: 17 · 2025: 19 · 2024: 17 · 2023: 22 · 2022: 34 · 2021: 28 · 2020: 21 · 2019: 18 · 2018: 18 · 2017: 11 · 2016: 10 · 2015: 8 · 2014: 4 · 2013: 3
FWCI
3.71
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmacological Research (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • Universidad de Chile (submittedVersion, cc-by-nc-nd)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords
gut microbiota, amino acid metabolism, short-chain fatty acids, sulfide, ammonia, colonic mucosa

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