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Proteomic analysis reveals altered expression of proteins related to glutathione metabolism and apoptosis in the small intestine of zinc oxide-supplemented piglets

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Growth control via TOR kinase signaling, an intracellular sensor of amino acid and energy availability, with crosstalk potential to proline metabolism

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Proline metabolism and cancer

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Prolidase function in proline metabolism and its medical and biotechnological applications

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Metabolic profiling in colorectal cancer reveals signature metabolic shifts during tumorigenesis

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l-proline increases survival of tilapias infected by Streptococcus agalactiae in higher water temperature

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Constituents of Propolis: Chrysin, Caffeic Acid, p-Coumaric Acid, and Ferulic Acid Induce PRODH/POX-Dependent Apoptosis in Human Tongue Squamous Cell Carcinoma Cell (CAL-27)

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Behavioral and neurochemical effects of proline

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Proline mediates metabolic communication between retinal pigment epithelial cells and the retina

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Proline dehydrogenase (oxidase) in cancer

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Proline Dehydrogenase Regulates Redox State and Respiratory Metabolism in Trypanosoma cruzi

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Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition

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Glucocorticoid regulation of amino acid and polyamine metabolism in the small intestine

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Oxidized low-density lipoproteins upregulate proline oxidase to initiate ROS-dependent autophagy

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Metabolomics of gastric cancer metastasis detected by gas chromatography and mass spectrometry

Chen, J. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i46.5874 · Cited by 78 · see citing works

Dietary supplementation with Chinese herbal powder enhances ileal digestibilities and serum concentrations of amino acids in young pigs

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Hydroxyproline supplementation on the performances of high plant protein source based diets in turbot (Scophthalmus maximus L.)

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Effect of proline supplementation on anti-oxidative capacity, immune response and stress tolerance of juvenile Pacific white shrimp, Litopenaeus vannamei

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Bridging epigenetics and metabolism

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Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicum

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Dietary nitrogen and fish welfare

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Serum and tissue metabolomics of head and neck cancer.

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Exogenous proline effects on water relations and ions contents in leaves and roots of young olive

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Celastrol Combats Methicillin‐Resistant Staphylococcus aureus by Targeting Δ1‐Pyrroline‐5‐Carboxylate Dehydrogenase

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A novel autoregulatory loop between the Gcn2-Atf4 pathway and L-Proline metabolism controls stem cell identity

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A Risk PRODH Haplotype Affects Sensorimotor Gating, Memory, Schizotypy, and Anxiety in Healthy Male Subjects

Roussos, P., Giakoumaki, S. G., & Bitsios, P. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.01.003 · Cited by 63 · see citing works

Role of apoptosis-inducing factor, proline dehydrogenase, and NADPH oxidase in apoptosis and oxidative stress

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Differential expression of novel metabolic and immunological biomarkers in oysters challenged with a virulent strain of OsHV-1

Young, T., Kesarcodi-Watson, A., Alfaro, A. C., Mérien, F., Nguyen, T. V., Mae, H., Le, D. V., & Villas-Bôas, S. G. (2017) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2017.03.025 · Cited by 61 · see citing works

Arginine: Challenges and opportunities of this two-faced molecule in cancer therapy

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Gastrointestinal interaction between dietary amino acids and gut microbiota: with special emphasis on host nutrition

Abdallah, A., Elemba, E., Zhong, Q., & Sun, Z. (2020) · Current Protein & Peptide Science · doi:10.2174/1389203721666200212095503 · Cited by 59 · see citing works

Proline dehydrogenase promotes senescence through the generation of reactive oxygen species

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“Alternative” fuels contributing to mitochondrial electron transport: Importance of non-classical pathways in the diversity of animal metabolism

McDonald, A. E., Pichaud, N., & Darveau, C.-A. (2017) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2017.11.006 · Cited by 59 · see citing works

P5C as an Interface of Proline Interconvertible Amino Acids and Its Role in Regulation of Cell Survival and Apoptosis

Chalecka, M., Kazberuk, A., Palka, J. A., & Surażyński, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111763 · Cited by 57 · see citing works

Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia

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Effects of dietary hydroxyproline on growth performance, body composition, hydroxyproline and collagen concentrations in tissues in relation to prolyl 4-hydroxylase α(I) gene expression of juvenile turbot, Scophthalmus maximus L. fed high plant protein diets

Zhang, K., Ai, Q., Mai, K., Xu, W., Liufu, Z., Zhang, Y., & Peng, M. (2013) · Aquaculture · doi:10.1016/j.aquaculture.2013.04.025 · Cited by 53 · see citing works

Glucose and glutamine metabolism in oral squamous cell carcinoma: insight from a quantitative metabolomic approach

Ogawa, T., Washio, J., Takahashi, T., Echigo, S., & Takahashi, N. (2014) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2014.04.003 · Cited by 53 · see citing works

Structural Biology of Proline Catabolic Enzymes

Tanner, J. J. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7374 · Cited by 51 · see citing works

Extracellular matrix endocytosis in controlling matrix turnover and beyond: emerging roles in cancer

Rainero, E. (2016) · Biochemical Society Transactions · doi:10.1042/bst20160159 · Cited by 50 · see citing works

Dietary l-proline supplementation confers immunostimulatory effects on inactivated Pasteurella multocida vaccine immunized mice

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Graphene Functionalized with Arginine Decreases the Development of Glioblastoma Multiforme Tumor in a Gene-Dependent Manner

Sawosz, E., Jaworski, S., Kutwin, M., Vadalasetty, K. P., Grodzik, M., Wierzbicki, M., Kurantowicz, N., Strojny, B., Hotowy, A., Lipińska, L., et al. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025214 · Cited by 44 · see citing works

Beyond protein synthesis: the emerging role of arginine in poultry nutrition and host-microbe interactions

Fathima, S., Hakeem, W. G. A., Selvaraj, R. K., & Shanmugasundaram, R. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2023.1326809 · Cited by 43 · see citing works

Crystal Structures and Kinetics of Monofunctional Proline Dehydrogenase Provide Insight into Substrate Recognition and Conformational Changes Associated with Flavin Reduction and Product Release

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The Uniqueness of the Trypanosoma cruzi Mitochondrion: Opportunities to Target New Drugs Against Chagas Disease

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Zonal regulation of collagen‐type proteins and posttranslational modifications in prostatic benign and cancer tissues by imaging mass spectrometry

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Plasma Metabolomic Profiles of Breast Cancer Patients after Short-term Limonene Intervention

Miller, J. A., Pappan, K. L., Thompson, P. A., Want, E. J., Siskos, A., Keun, H. C., Wulff, J. E., Hu, C., Lang, J. E., & Chow, H. ‐. S. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0100 · Cited by 41 · see citing works

Systematic analyses of glutamine and glutamate metabolisms across different cancer types

Tian, Y., Du, W., Cao, S., Wu, Y., Dong, N., Wang, Y., & Xu, Y. (2017) · 癌症：英文版 · doi:10.1186/s40880-017-0255-y · Cited by 41 · see citing works

Prolidase‐proline dehydrogenase/proline oxidase‐collagen biosynthesis axis as a potential interface of apoptosis/autophagy

Zaręba, I., & Palka, J. A. (2016) · BioFactors · doi:10.1002/biof.1283 · Cited by 40 · see citing works

Human proline specific peptidases: A comprehensive analysis

Dunaevsky, Y. E., Tereshchenkova, V. F., Oppert, B., Belozersky, M. A., FILIPPOVA, I. Y., & Elpidina, E. N. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129636 · Cited by 40 · see citing works

Protein and amino acids

Mai, K., Xue, M., He, G., Xie, S., & Kaushik, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819587-1.00012-4 · Cited by 39 · see citing works

A fragment-like approach to PYCR1 inhibition

Milne, K., Sun, J., Zaal, E. A., Mowat, J. M., Celie, P. H. N., Fish, A., Berkers, C. R., Forlani, G., Loayza‐Puch, F., Jamieson, C. J., et al. (2019) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2019.07.047 · Cited by 38 · see citing works

Enzymes in Metabolic Anticancer Therapy

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Role of lung ornithine aminotransferase in idiopathic pulmonary fibrosis: regulation of mitochondrial ROS generation and TGF-β1 activity

Lee, J.-U., Song, K. S., Hong, J., Shin, H., Park, E. J., Baek, J., Park, S., Baek, A.-R., Lee, J.-H., Jang, A. S., et al. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01170-w · Cited by 40 · see citing works

Evidence that COMT genotype and proline interact on negative-symptom outcomes in schizophrenia and bipolar disorder

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Proline dehydrogenase is a positive regulator of cell death in different kingdoms

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Oxidative Phosphorylation as a Target to Arrest Malignant Neoplasias

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Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line

Cappelletti, P., Tallarita, E., Rabattoni, V., Campomenosi, P., Sacchi, S., & Pollegioni, L. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196283 · Cited by 36 · see citing works

Proline Protects Boar Sperm against Oxidative Stress through Proline Dehydrogenase-Mediated Metabolism and the Amine Structure of Pyrrolidine

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OVCAR-3 Spheroid-Derived Cells Display Distinct Metabolic Profiles

Vermeersch, K. A., Wang, L., Mezencev, R., McDonald, J. F., & Styczynski, M. P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118262 · Cited by 35 · see citing works

Reactive Oxygen Species Homeostasis and Virulence of the Fungal PathogenCryptococcus neoformansRequires an Intact Proline Catabolism Pathway

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Amino Acid Biosignature in Plasma among Ischemic Stroke Subtypes

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Proline ‐ A Critical “Stress Substrate” for Bioenergetics and Programmed Cell Death

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Proline Metabolism and Microenvironmental Stress

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Collagen metabolism as a regulator of proline dehydrogenase/proline oxidase-dependent apoptosis/autophagy

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Proline oxidase (dehydrogenase) generates switchable bioenergetics for cancer cell survival or programmed cell death

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