Serotonin and molecular neuroimaging in humans using PET

Saulin, Anne; Savli, Markus; Lanzenberger, Rupert

doi:10.1007/s00726-011-1078-9

Cited by 113Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchTryptophan and brain disorders

Serotonin and molecular neuroimaging in humans using PET

Saulin, Anne, Savli, Markus, Lanzenberger, Rupert·2012·Amino Acids

DOI 10.1007/s00726-011-1078-9

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Abstract

The serotonergic system is one of the most important modulatory neurotransmitter systems in the human brain. It plays a central role in major physiological processes and is implicated in a number of psychiatric disorders. Along with the dopaminergic system, it is also one of the phylogenetically oldest human neurotransmitter systems and one of the most diverse, with 14 different receptors identified up to this day, many of whose function remains to be understood. The system's functioning is even more diverse than the number of its receptors, since each is implicated in a number of different processes. This review aims at illustrating the distribution and summarizing the main functions of the serotonin (5-hydroxytryptamin, 5-HT) receptors as well as the serotonin transporter (SERT, 5-HTT), the vesicular monoamine transporter 2, monoamine oxidase type A and 5-HT synthesis in the human brain. Recent advances in in vivo quantification of these different receptors and enzymes that are part of the serotonergic system using positron emission tomography are described.

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Villemagne, V. L. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.142 · Cited by 43 · see citing works
High-resolution imaging of brain 5-HT1B receptors in the rhesus monkey using [11C]P943
Nabulsi, N., Huang, Y. H., Weinzimmer, D. P., Ropchan, J. R., Frost, J. J., McCarthy, T., Carson, R. E., & Ding, Y. (2009) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2009.10.007 · Cited by 42 · see citing works
Vesicular Monoamine Transporters (VMATs) in Adrenal Chromaffin Cells: Stress-Triggered Induction of VMAT2 and Expression in Epinephrine Synthesizing Cells
Tillinger, A., Sollas, A. L., Serova, L. I., Květňanský, R., & Sabban, E. L. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-010-9575-z · Cited by 42 · see citing works
An improved radiosynthesis of [18F]AV-133: a PET imaging agent for vesicular monoamine transporter 2
Zhu, L., Liu, Y., Plöessl, K., Lieberman, B. P., Liu, J., & Kung, H. F. (2009) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2009.10.005 · Cited by 41 · see citing works
Central serotonin 1A receptor binding in temporal lobe epilepsy: A [carbonyl-11C]WAY-100635 PET study
Assem‐Hilger, E., Lanzenberger, R. R., Savli, M., Wadsak, W., Mitterhauser, M., Mien, L., Stögmann, E., Baumgartner, C., Kletter, K., & Asenbaum, S. (2010) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2010.07.030 · Cited by 41 · see citing works
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Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population
Yosifova, A., Mushiroda, T., Stoianov, D., Vazharova, R., Dimova, I. I., Karachanak-Yankova, S., Zaharieva, I. T., Milanova, V. K., Madjirova, N., Gerdjikov, I., et al. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2008.12.021 · Cited by 41 · see citing works
Expression and role of 5-HT7 receptor in brain and intestine in rats with irritable bowel syndrome
Zou, B., Dong, L., Wang, Y., Wang, S., & Ming-bo, C. A. O. (2007) · Chinese Medical Journal · doi:10.1097/00029330-200712010-00002 · Cited by 40 · see citing works
In vivo studies of the SERT-selective [18F]FPBM and VMAT2-selective [18F]AV-133 radiotracers in a rat model of Parkinson's disease
Wang, J. L., Oya, S., Parhi, A. K., Lieberman, B. P., Plöessl, K., Hou, C., & Kung, H. F. (2010) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2010.01.006 · Cited by 40 · see citing works
In vivo kinetics of [F‐18]MEFWAY: A comparison with [C‐11]WAY100635 and [F‐18]MPPF in the nonhuman primate
Wooten, D., Moraino, J. D., Hillmer, A. T., Engle, J. W., DeJesus, O. T., Murali, D., Barnhart, T. E., Nickles, R. J., Davidson, R. J., Schneider, M. L., et al. (2010) · Synapse · doi:10.1002/syn.20878 · Cited by 40 · see citing works
Neural and psychological predictors of treatment response in irritable bowel syndrome patients with a 5-HT3 receptor antagonist: a pilot study
Jarcho, J., Chang, L., Berman, S. M., Suyenobu, B. Y., Naliboff, B., Lieberman, M. D., Ameen, V. Z., Mandelkern, M., & Mayer, E. (2008) · Alimentary Pharmacology and Therapeutics · doi:10.1111/j.1365-2036.2008.03721.x · Cited by 39 · see citing works
Regional distribution and behavioral correlates of 5-HT2A receptors in Alzheimer's disease with [18F]deuteroaltanserin and PET
Santhosh, L., Estok, K. M., Vogel, R. S., Tamagnan, G. D., Baldwin, R. M., Mitsis, E. M., MacAvoy, M. G., Staley, J. K., & van Dyck, C. H. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2009.03.007 · Cited by 37 · see citing works
Multimodal imaging of human early visual cortex by combining functional and molecular measurements with fMRI and PET
Gerstl, F., Windischberger, C., Mitterhauser, M., Wadsak, W., Holik, A., Kletter, K., Moser, E., Kasper, S. F., & Lanzenberger, R. R. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.02.044 · Cited by 36 · see citing works
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Medicinal Chemistry of 5-HT5A Receptor Ligands: A Receptor Subtype with Unique Therapeutical Potential
Volk, B., Nagy, B. J., Vas, S., Kostyalik, D., Simig, G., & Bagdy, G. (2010) · Current Topics in Medicinal Chemistry · doi:10.2174/156802610791111588 · Cited by 36 · see citing works
Serotonin and dopamine transporters in relation to neuropsychological functioning, personality traits and mood in young adult healthy subjects
Burke, S., van de Giessen, E., de Win, M. M. L., Schilt, T., van Herk, M., van den Brink, W., & Booij, J. (2010) · Psychological Medicine · doi:10.1017/s0033291710000486 · Cited by 35 · see citing works
Increasing blood oxygen increases an index of 5-HT synthesis in human brain as measured using α-[11C]methyl-l-tryptophan and positron emission tomography
Nishikawa, M., Kumakura, Y., Young, S. N., Fiset, P., Vogelzangs, N., Leyton, M., Benkelfat, C., & Dikšić, M. (2005) · Neurochemistry International · doi:10.1016/j.neuint.2005.07.006 · Cited by 35 · see citing works
5-HT1F Receptor Agonists: A New Treatment Option for Migraine Attacks?
Neeb, L., Meents, J., & Reuter, U. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.03.003 · Cited by 34 · see citing works
Monoamine Oxidase: Radiotracer Development and Human Studies
Fowler, J. S., Logan, J., Volkow, N. D., Wang, G., MacGregor, R. R., & Ding, Y. (2003) · Springer eBooks · doi:10.1007/978-3-642-55539-8_20 · Cited by 33 · see citing works
Distribution of Vesicular Monoamine Transporter 2 Protein in Human Brain: Implications for Brain Imaging Studies
Tong, J., Boileau, I., Furukawa, Y., Chang, L., Wilson, A. A., Houle, S., & Kish, S. J. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.63 · Cited by 33 · see citing works
Dose-dependent binding of AZD3783 to brain 5-HT1B receptors in non-human primates and human subjects: a positron emission tomography study with [11C]AZ10419369
Varnäs, K., Nyberg, S., Karlsson, P., Pierson, M. E., Kågedal, M., Cselényi, Z., McCarthy, D. J., Xiao, A. J., Zhang, M., Halldin, C., et al. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2165-z · Cited by 33 · see citing works
Serotonin 5-HT6 receptor blockade reverses the age-related deficits of recognition memory and working memory in mice
Costa-Aze, V. D. S., Dauphin, F., & Boulouard, M. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.046 · Cited by 33 · see citing works
Hyperfunction of Muscarinic Receptor Maintains Long-Term Memory in 5-HT4 Receptor Knock-Out Mice
Ségu, L., Lecomte, M.-J., Wolff, M., Santamaria, J., Hen, R., Dumuis, A., Berrard, S., Bockaert, J., Buhot, M.-C., & Compan, V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009529 · Cited by 32 · see citing works
Design, Synthesis, and Biological Evaluation of New 5-HT4 Receptor Agonists: Application as Amyloid Cascade Modulators and Potential Therapeutic Utility in Alzheimer’s Disease
Russo, O., Cachard-Chastel, M., Rivière, C., Giner, M., Soulier, J. L., Berthouze, M., Richard, T., Monti, J., Sicsic, S., Lezoualc’h, F., et al. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm801327q · Cited by 31 · see citing works
Strategy for the Formation of Parametric Images Under Conditions of Low Injected Radioactivity Applied to PET Studies With the Irreversible Monoamine Oxidase A Tracers [11C]Clorgyline and Deuterium-Substituted [11C]Clorgyline
Logan, J., Fowler, J. S., Ding, Y., Franceschi, D., Wang, G., Volkow, N. D., Felder, C. A., & Alexoff, D. L. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000040947.67415.e1 · Cited by 30 · see citing works
5-HT7 receptor deletion enhances REM sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-HT1A receptor
Shelton, J. E., Bonaventure, P., Li, X., Yun, S., Lovenberg, T. W., & Dugovic, C. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.09.014 · Cited by 30 · see citing works
Mapping the Cerebral Monoamine Oxidase Type A: Positron Emission Tomography Characterization of the Reversible Selective Inhibitor [11C]Befloxatone
Bottlaender, M., Dollé, F., Guenther, I., Roumenov, D., Fuseau, C., Bramoullé, Y., Curet, O., Jegham, J., Pinquier, J., George, P. G., et al. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.046953 · Cited by 30 · see citing works
Tryptophan hydroxylase and serotonin synthesis regulation
Kuhn, D. M., & Hasegawa, H. (2020) · Handbook of Behavioral Neuroscience · doi:10.1016/s1569-7339(10)70078-3 · Cited by 29 · see citing works
Serotonin transporter binding in the hypothalamus correlates negatively with tonic heat pain ratings in healthy subjects: A [11C]DASB PET study
Kupers, R. C., Frøkjær, V. G., Erritzøe, D., Naert, A., Budtz–Jørgensen, E., Nielsen, F. Å., Kehlet, H., & Knudsen, G. M. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.09.010 · Cited by 29 · see citing works
Paradoxical constitutive behavioral sensitization to amphetamine in mice lacking 5-HT2A receptors
Salomon, L., Lanteri, C., Godeheu, G., Blanc, G., Gingrich, J. A., & Tassin, J. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0810-3 · Cited by 28 · see citing works
Synthesis and biological evaluation of potential 5-HT7 receptor PET radiotracers
Andriès, J., Lemoine, L., Bars, D. L., Zimmer, L., & Billard, T. (2011) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2011.05.010 · Cited by 28 · see citing works
Effect of monoamine oxidase inhibition on amphetamine-evoked changes in dopamine receptor availability in the living pig: A dual tracer PET study with [11C]harmine and [11C]raclopride
Jensen, S. B., Olsen, A. K., Pedersen, K., & Cumming, P. (2006) · Synapse · doi:10.1002/syn.20258 · Cited by 27 · see citing works
Development of a PET radioligand for the central 5-HT1B receptor: radiosynthesis and characterization in cynomolgus monkeys of eight radiolabeled compounds
Andersson, J. D., Pierson, M. E., Finnema, S. J., Gulyás, B. Z., Heys, R., Elmore, C. S., Farde, L., & Halldin, C. (2010) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2010.08.006 · Cited by 27 · see citing works
Synthesis and preliminary PET study of the 5‐HT7 receptor antagonist [11C]DR4446
Zhang, M., Haradahira, T., Maeda, J., Okauchi, T., Kida, T., Obayashi, S., Suzuki, K., & Suhara, T. (2002) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.606 · Cited by 27 · see citing works
18F-Labeling and evaluation of novel MDL 100907 derivatives as potential 5-HT2A antagonists for molecular imaging
Debus, F., Herth, M. M., Piel, M., Buchholz, H., Bausbacher, N., Kramer, V., Lüddens, H., & Rösch, F. (2010) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2010.02.002 · Cited by 26 · see citing works
Synthesis of new N-heteroaryl derivatives of 4-pyrones from kojic acid based Baylis–Hillman acetates
Ghasemi, Z., Eshtad, M., & Mejarshin, F. P. (2013) · Chemistry of Heterocyclic Compounds · doi:10.1007/s10593-013-1188-2 · Cited by 25 · see citing works
Design, synthesis and structure–activity relationship of novel quinoxalin-2-carboxamides as 5-HT3 receptor antagonists for the management of depression
Mahesh, R., Devadoss, T., Pandey, D. K., Bhatt, S., & Yadav, S. K. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.08.128 · Cited by 24 · see citing works
Antiangiogenic Effect of a Selective 5-HT4 Receptor Agonist
Nishikawa, T., Tsuno, N. H., Shuno, Y., Sasaki, K., Hongo, K., Okaji, Y., Sunami, E., Kitayama, J., Takahashi, K., & Nagawa, H. (2008) · Journal of Surgical Research · doi:10.1016/j.jss.2008.11.004 · Cited by 23 · see citing works
Synthesis, Structure−Affinity Relationships, and Radiolabeling of Selective High-Affinity 5-HT4Receptor Ligands as Prospective Imaging Probes for Positron Emission Tomography
Xu, R., Hong, J. S., Morse, C. L., & Pike, V. W. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100668r · Cited by 22 · see citing works
Decreased platelet vesicular monoamine transporter density in habitual smokers
Schwartz, K., Weizman, A., & Rehavi, M. (2005) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2004.11.001 · Cited by 22 · see citing works
The pyramidal neurons in the medial prefrontal cortex show decreased response to 5-hydroxytryptamine-3 receptor stimulation in a rodent model of Parkinson's disease
Zhang, Q., Li, L. B., Niu, X. L., Liu, J., Gui, Z. H., Feng, J. J., Ali, U., Hui, Y., & Wu, Z. H. (2011) · Brain Research · doi:10.1016/j.brainres.2011.01.086 · Cited by 22 · see citing works
Synthesis of new carbon-11 labeled benzoxazole derivatives for PET imaging of 5-HT3 receptor
Gao, M., Wang, M., Hutchins, G. D., & Zheng, Q. (2007) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2007.10.017 · Cited by 22 · see citing works
Association Study between 5-HT1A Receptor Gene C(-1019)G Polymorphism and Panic Disorder in a Korean Population
Choi, W.-S., Lee, B.-H., Yang, J.-C., & Kim, Y. (2010) · Psychiatry Investigation · doi:10.4306/pi.2010.7.2.141 · Cited by 22 · see citing works
Differential pharmacotherapy for subgroups of fibromyalgia patients with specific consideration of 5-HT3 receptor antagonists
Seidel, M. F., & Müller, W. (2011) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2011.557362 · Cited by 22 · see citing works
Functional Neuroimaging in Geriatric Depression
Gunning, F. M., & Smith, G. S. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2011.02.010 · Cited by 21 · see citing works
An in vivo comparison of cis- and trans-[18F]mefway in the nonhuman primate
Wooten, D., Hillmer, A. T., Murali, D., Barnhart, T. E., Schneider, M. L., Mukherjee, J., & Christian, B. T. (2011) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2011.04.001 · Cited by 20 · see citing works
Stability of α-[11C]methyl-l-tryptophan brain trapping in healthy male volunteers
Rosa‐Neto, P., Dikšić, M., Leyton, M., Mzengeza, S., & Benkelfat, C. (2005) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-1829-5 · Cited by 18 · see citing works
Influence of a low dose of amphetamine on vesicular monoamine transporter binding: A PET (+)[11C]DTBZ study in humans
Boileau, I., Houle, S., Rusjan, P., Furukawa, Y., Wilkins, D. G., Tong, J., Selby, P. L., Wilson, A. A., & Kish, S. J. (2010) · Synapse · doi:10.1002/syn.20743 · Cited by 17 · see citing works
Pharmacogenetic study of serotonin 6 receptor gene with antidepressant response in major depressive disorder in the Japanese population
Kishi, T., Fukuo, Y., Yoshimura, R., Okochi, T., Kitajima, T., Naitoh, H., Umene‐Nakano, W., Nakamura, J., Ozaki, N., & Iwata, N. (2010) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1142 · Cited by 16 · see citing works
Evaluation of the novel 5-HT6 receptor radioligand, [11C]GSK-215083 in human
Parker, C. A., Cunningham, V. J., Martarello, L., Rabiner, E. A., Searle, G. E., Gee, A. D., Davy, M., Johnson, C. N., Ahmed, M. M. A., Gunn, R. N., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.04.194 · Cited by 14 · see citing works
Radiosynthesis and in vivo evaluation of [11C]-labelled pyrrole-2-carboxamide derivates as novel radioligands for PET imaging of monoamine oxidase A
Bruyne, S. D., Regina, G. L., Staelens, S. G., Wyffels, L., Deleye, S., Silvestri, R., & Vos, F. D. (2010) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2009.09.005 · Cited by 14 · see citing works

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Psychedelic drugs: neurobiology and potential for treatment of psychiatric disorders
Vollenweider, F. X., & Preller, K. H. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0367-2 · Cited by 570 · see citing works
Increased global functional connectivity correlates with LSD-induced ego dissolution
Tagliazucchi, E., Roseman, L., Kaelen, M., Orban, C., Muthukumaraswamy, S. D., Murphy, K., Laufs, H., Leech, R., McGonigle, J., Crossley, N., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.02.010 · Cited by 503 · see citing works
Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor
Preller, K. H., Burt, J. B., Ji, J. L., Schleifer, C. H., Adkinson, B. D., Stämpfli, P., Seifritz, E., Repovs, G., Krystal, J. H., Murray, J. D., et al. (2018) · eLife · doi:10.7554/elife.35082 · Cited by 390 · see citing works
The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation
Preller, K. H., Herdener, M., Pokorny, T., Planzer, A., Kraehenmann, R., Stämpfli, P., Liechti, M. E., Seifritz, E., & Vollenweider, F. X. (2017) · Current Biology · doi:10.1016/j.cub.2016.12.030 · Cited by 402 · see citing works
Normative database of the serotonergic system in healthy subjects using multi-tracer PET
Savli, M., Bauer, A., Mitterhauser, M., Ding, Y.-S., Hahn, A., Kroll, T., Neumeister, A., Haeusler, D., Ungersboeck, J., Henry, S., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.07.001 · Cited by 251 · see citing works
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Opposite effects of dopamine and serotonin on resting-state networks: review and implications for psychiatric disorders
Conio, B., Martino, M., Magioncalda, P., Escelsior, A., Inglese, M., Amore, M., & Northoff, G. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0406-4 · Cited by 254 · see citing works
Meta-analysis of molecular imaging of serotonin transporters in major depression
Gryglewski, G., Lanzenberger, R., Kranz, G. S., & Cumming, P. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.82 · Cited by 227 · see citing works
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Modulatory effect of the 5-HT1A agonist buspirone and the mixed non-hallucinogenic 5-HT1A/2A agonist ergotamine on psilocybin-induced psychedelic experience.
Pokorny, T., Preller, K., Kraehenmann, R., & Vollenweider, F. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.01.005 · Cited by 116 · see citing works
Differential modulation of the default mode network via serotonin-1A receptors
Hahn, A., Wadsak, W., Windischberger, C., Baldinger, P., Höflich, A. S., Lošák, J., Nics, L., Philippe, C., Kranz, G. S., Kraus, C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117104109 · Cited by 129 · see citing works
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Global decrease of serotonin-1A receptor binding after electroconvulsive therapy in major depression measured by PET
Lanzenberger, R. R., Baldinger, P., Hahn, A., Ungersboeck, J., Mitterhauser, M., Winkler, D., Micskei, Z., Stein, P., Karanikas, G., Wadsak, W., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.93 · Cited by 120 · see citing works
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Classic Psychedelic Drugs: Update on Biological Mechanisms
Vollenweider, F. X., & Smallridge, J. W. (2022) · Pharmacopsychiatry · doi:10.1055/a-1721-2914 · Cited by 112 · see citing works
Serotonergic mechanisms in the migraine brain – a systematic review
Deen, M., Christensen, C. E., Hougaard, A., Hansen, H. D., Knudsen, G. M., & Ashina, M. (2016) · Cephalalgia · doi:10.1177/0333102416640501 · Cited by 108 · see citing works
The Experience Elicited by Hallucinogens Presents the Highest Similarity to Dreaming within a Large Database of Psychoactive Substance Reports
Sanz, C., Zamberlán, F., Erowid, E., Erowid, F., & Tagliazucchi, E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00007 · Cited by 107 · see citing works
Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation
Kamlet, A. S., Neumann, C. N., Lee, E., Carlin, S. M., Moseley, C. K., Stephenson, N. A., Hooker, J. M., & Ritter, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059187 · Cited by 99 · see citing works
Serotonin, neural markers, and memory
Meneses, A. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00143 · Cited by 90 · see citing works
Genetic and biochemical changes of the serotonergic system in migraine pathobiology
Gasparini, C., Smith, R. A., & Griffiths, L. R. (2017) · The Journal of Headache and Pain · doi:10.1186/s10194-016-0711-0 · Cited by 87 · see citing works
Neural Mechanisms and Psychology of Psychedelic Ego Dissolution
Stoliker, D., Egan, G. F., Friston, K. J., & Razi, A. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000508 · Cited by 89 · see citing works
Psilocybin and MDMA for the treatment of trauma-related psychopathology
Bird, C., Modlin, N. L., & Rucker, J. (2021) · International Review of Psychiatry · doi:10.1080/09540261.2021.1919062 · Cited by 84 · see citing works
5-HT systems: emergent targets for memory formation and memory alterations
Meneses, A. (2013) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0026 · Cited by 79 · see citing works
Common and distinct brain networks underlying panic and social anxiety disorders
Kim, Y.-K., & Yoon, H.-K. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.06.017 · Cited by 78 · see citing works
Serotonin and Aversive Pavlovian Control of Instrumental Behavior in Humans
Geurts, D. E. M., Huys, Q. J. M., den Ouden, H. E. M., & Cools, R. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2749-13.2013 · Cited by 78 · see citing works
Differential induction of FosB isoforms throughout the brain by fluoxetine and chronic stress
Vialou, V., Thibault, M., Kaska, S., Cooper, S., Gajewski, P. A., Eagle, A. L., Mazei‐Robison, M. S., Nestler, E. J., & Robison, A. J. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.07.005 · Cited by 72 · see citing works
Relationship between nuclei-specific amygdala connectivity and mental health dimensions in humans
Klein-Flügge, M. C., Jensen, D. E. A., Takagi, Y., Priestley, L., Verhagen, L., Smith, S. M., & Rushworth, M. F. S. (2022) · Nature Human Behaviour · doi:10.1038/s41562-022-01434-3 · Cited by 64 · see citing works
More than meets the eye: The role of sensory dimensions in psychedelic brain dynamics, experience, and therapeutics
Aqil, M., & Roseman, L. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109300 · Cited by 58 · see citing works
The role of serotonin in depression—A historical roundup and future directions
Bremshey, S., Groß, J., Renken, K., & Masseck, O. A. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16097 · Cited by 60 · see citing works
The serotonin hallucinogen 5-MeO-DMT alters cortico-thalamic activity in freely moving mice: Regionally-selective involvement of 5-HT1A and 5-HT2A receptors
Riga, M. S., Lladó-Pelfort, L., Artigas, F., & Celada, P. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.049 · Cited by 50 · see citing works
PET Tracers for Serotonin Receptors and Their Applications
Kumar, J. S. D., & Mann, J. (2015) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1871524914666141030124316 · Cited by 48 · see citing works
Memory formation and memory alterations: 5-HT6 and 5-HT7 receptors, novel alternative
Meneses, A. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0001 · Cited by 49 · see citing works
Turn-On Near-Infrared Fluorescent Sensor for Selectively Imaging Serotonin
Hettie, K. S., & Glass, T. E. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00235 · Cited by 49 · see citing works
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Authors: Saulin, A., Savli, M., & Lanzenberger, R.
Affiliations: Medical University of Vienna (AT)
Corresponding author: Lanzenberger, Rupert
ORCID: Saulin, Anne
Lanzenberger, Rupert
Venue: Amino Acids
Publisher: Springer Science and Business Media LLC
Published: 2011-09-24
Volume: 42
Issue: 6
Pages: 2039-2057
ISSN: 0939-4451 (ISSN-L)
1438-2199
DOI: 10.1007/s00726-011-1078-9
OpenAlex: W2054129965
Cited by: 113
References: 207
Citations by year: 2026: 5 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 11 · 2017: 10 · 2016: 8 · 2015: 7 · 2014: 9 · 2013: 7 · 2012: 8
FWCI: 0.73
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Amino Acids (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: serotonin, serotonergic system, serotonin receptors, serotonin transporter, vesicular monoamine transporter 2, monoamine oxidase A, serotonin synthesis, positron emission tomography, human brain, mental illness
MeSH terms: Animals, Brain, Humans, Monoamine Oxidase, Synaptic Transmission, Receptors, Serotonin, Serotonin, Serotonin Agents, Radiopharmaceuticals, Positron-Emission Tomography, Serotonin Plasma Membrane Transport Proteins, Vesicular Monoamine Transport Proteins, Mice, Molecular Imaging

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Serotonin and molecular neuroimaging in humans using PET

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