Cited by 71Muscle metabolism and nutritionBiochemical effects in animalsSports Performance and Training

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Guanidinoacetic acid as a performance-enhancing agent

Ostojic, Sergej M.·2016·Amino Acids

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Abstract

Guanidinoacetic acid (GAA; also known as glycocyamine or guanidinoacetate) is the natural precursor of creatine, and under investigation as a novel dietary agent. It was first identified as a natural compound in humans ~80 years ago. In the 1950s, GAA's use as a therapeutic agent was explored, showing that supplemental GAA improved patient-reported outcomes and work capacity in clinical populations. Recently, a few studies have examined the safety and efficacy of GAA and suggest potential ergogenic benefits for physically active men and women. The purpose of this review is to examine possible applications of GAA supplementation for exercise performance enhancement, safety, and legislation issues.

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Authors: Ostojic, S. M.
Venue: Amino Acids
Publisher: Springer Science and Business Media LLC
Published: 2015-10-07
Volume: 48
Issue: 8
Pages: 1867-1875
ISSN: 0939-4451 (ISSN-L)
1438-2199
DOI: 10.1007/s00726-015-2106-y
OpenAlex: W1835122042
Cited by: 71
References: 65
Citations by year: 2026: 5 · 2025: 12 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 12 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 1
FWCI: 0.43
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Amino Acids (publishedVersion)
PubMed (publishedVersion)
Funders: Serbian Ministry of Science (175037)
Faculty of Sport and Physical Education (2015 Annual Award)
AlzChem AG, Trostberg, Germany
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology (medical) › Biochemical effects in animals
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords: guanidinoacetic acid, glycocyamine, creatine precursor, dietary supplementation, ergogenic aids, exercise performance, work capacity, supplement safety, supplement regulation
MeSH terms: Animals, Female, Glycine, Humans, Male, Dietary Supplements, Performance-Enhancing Substances

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Guanidinoacetic acid as a performance-enhancing agent

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