The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Guanidinoacetic acid as a performance-enhancing agent
Abstract
Guanidinoacetic acid (GAA; also known as glycocyamine or guanidinoacetate) is the natural precursor of creatine, and under investigation as a novel dietary agent. It was first identified as a natural compound in humans ~80 years ago. In the 1950s, GAA's use as a therapeutic agent was explored, showing that supplemental GAA improved patient-reported outcomes and work capacity in clinical populations. Recently, a few studies have examined the safety and efficacy of GAA and suggest potential ergogenic benefits for physically active men and women. The purpose of this review is to examine possible applications of GAA supplementation for exercise performance enhancement, safety, and legislation issues.
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“Since creatine uptake by the brain is slow and limited, current research is investigating whether dietary supplementation of creatine precursors like GAA may promote greater increases in brain creatine [226, 227].”
From International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine (2017) · cites this paper as [226]
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Cited by
Kreider, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., Candow, D. G., Kleiner, S. M., Almada, A. L., & Lopez, H. L. (2017) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-017-0173-z · Cited by 1,057
“Since creatine uptake by the brain is slow and limited, current research is investigating whether dietary supplementation of creatine precursors like GAA may promote greater increases in brain creatine [226, 227].”
BackgroundThe chemistry and biology of guanidine natural products
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The chemistry and biology of guanidine natural products
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Amiri, M., Ghasemi, H. A., Hajkhodadadi, I., & Farahani, A. H. K. (2019) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2019.114208 · Cited by 67
Li, J., Zhang, L., Fu, Y., Li, Y., Jiang, Y., Zhou, G., & Gao, F. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b02534 · Cited by 66
Metadata
- Authors
- Ostojic, S. M.
- Venue
- Amino Acids
- Published
- 2015-10-07
- Volume
- 48
- Issue
- 8
- Pages
- 1867-1875
- ISSN
- 0939-4451 (ISSN-L)
- 1438-2199
- OpenAlex
- W1835122042
- Cited by
- 71
- References
- 65
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 12 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 1
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Amino Acids (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Serbian Ministry of Science (175037)
- Faculty of Sport and Physical Education (2015 Annual Award)
- AlzChem AG, Trostberg, Germany
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Biochemical effects in animals
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- guanidinoacetic acid, glycocyamine, creatine precursor, dietary supplementation, ergogenic aids, exercise performance, work capacity, supplement safety, supplement regulation
- MeSH terms
- Animals, Female, Glycine, Humans, Male, Dietary Supplements, Performance-Enhancing Substances
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