RANKL as the master regulator of osteoclast differentiation

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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.

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Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

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The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

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Genetic regulation of osteoclast development and function

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RANK is essential for osteoclast and lymph node development.

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The Macrophage-Osteoclast Axis in Osteoimmunity and Osteo-Related Diseases

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The RANK/RANKL/OPG system and tumor bone metastasis: Potential mechanisms and therapeutic strategies

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Aconine attenuates osteoclast-mediated bone resorption and ferroptosis to improve osteoporosis via inhibiting NF-κB signaling

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Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis

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Cleaved SPP1-rich extracellular vesicles from osteoclasts promote bone regeneration via TGFβ1/SMAD3 signaling

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The role of TNF-α in osteoporosis, bone repair and inflammatory bone diseases: A review

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NRF2 is essential for iron-overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis

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Icariin ameliorates osteoporosis in ovariectomized rats by targeting Cullin 3/Nrf2/OH pathway for osteoclast inhibition

Si, Y., Li, Y., Gu, K., Yin, H., & Ma, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116422 · Cited by 57

Pharmacology-based molecular docking of 4-methylcatechol and its role in RANKL-mediated ROS/Keap1/Nrf2 signalling axis and osteoclastogenesis

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The immunological significance of tumor necrosis factor receptor-associated factors (TRAFs)

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The monocyte-to-osteoclast transition in rheumatoid arthritis: Recent findings

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Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration

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Polyphenols as potential preventers of osteoporosis: A comprehensive review on antioxidant and anti-inflammatory effects, molecular mechanisms, and signal pathways in bone metabolism

Su, Z., Yao, B., Liu, G., & Fang, J. Q. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109488 · Cited by 49

Osteoclast biology in the single-cell era

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Redox signaling and antioxidant defense in osteoclasts

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Subchondral osteoclasts and osteoarthritis: new insights and potential therapeutic avenues

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Curcumin-encapsulated exosomes in bisphosphonate-modified hydrogel microspheres promote bone repair through macrophage polarization and DNA damage mitigation

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Small-molecule amines: a big role in the regulation of bone homeostasis

Zhang, Q., Yang, J., Hu, N., Liu, J., Yu, H., Pan, H., Chen, D., & Ruan, C. (2023) · Bone Research · doi:10.1038/s41413-023-00262-z · Cited by 34

Profiling joint tissues at single-cell resolution: advances and insights

Pandey, A., & Bhutani, N. (2023) · Nature Reviews Rheumatology · doi:10.1038/s41584-023-01052-x · Cited by 34

Tussilagone inhibits osteoclastogenesis by modulating mitochondrial function and ROS production involved Nrf2 activation

Feng, X., Liu, Z., Su, Y., Lian, H., Gao, Y., Zhao, J., Xu, J., Liu, Q., & Song, F. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115895 · Cited by 31

Review of potential medical treatments for middle ear cholesteatoma

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Guizhi Shaoyao Zhimu granules attenuate bone destruction in mice with collagen-induced arthritis by promoting mitophagy of osteoclast precursors to inhibit osteoclastogenesis

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Neutrophils in Inflammatory Bone Diseases

Carmona‐Rivera, C., Kaplan, M. J., & O’Neil, L. J. (2024) · Current Osteoporosis Reports · doi:10.1007/s11914-024-00865-3 · Cited by 28

Bone marrow derived stromal cells from myelodysplastic syndromes are altered but not clonally mutated in vivo

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Osteoclastogenesis inhibitory phenolic derivatives produced by the Beibu Gulf coral-associated fungus Acremonium sclerotigenum GXIMD 02501

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Enhancing osteoinduction and bone regeneration of biphasic calcium phosphate scaffold thought modulating the balance between pro-osteogenesis and anti-osteoclastogenesis by zinc doping

Lu, T., Yuan, X., Zhang, L., He, F., Wang, X., & Ye, J. (2023) · Materials Today Chemistry · doi:10.1016/j.mtchem.2023.101410 · Cited by 24

Circadian clock genes as promising therapeutic targets for bone loss

Qin, Y., Chen, Z.-H., Wu, J.-J., Zhang, Z., Yuan, Z., Guo, D., Chen, M.-N., Li, X., & Yuan, F. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114019 · Cited by 25

Puerarin alleviates cadmium‐induced oxidative damage to bone by reducing autophagy in rats

Tong, X., Yu, G., Liu, Q., Zhang, X., Bian, J., Liu, Z., & Gu, J. (2021) · Environmental Toxicology · doi:10.1002/tox.23437 · Cited by 23

YTHDF1 regulates endoplasmic reticulum stress, NF-κB, MAPK and PI3K-AKT signaling pathways in inflammatory osteoclastogenesis

He, M., Li, D., Fang, C., & Xu, Q. (2022) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2022.109464 · Cited by 22

Discovery of a First-in-Class GPR183 Antagonist for the Potential Treatment of Rheumatoid Arthritis

Xi, J., Gong, H., Li, Z., Li, Y., Wu, Y., Zhang, Y., Wang, J., & Fan, G.-H. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01364 · Cited by 19

Multinucleation resets human macrophages for specialized functions at the expense of their identity

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Enhancement of Bone Tissue Regeneration with Multi‐Functional Nanoparticles by Coordination of Immune, Osteogenic, and Angiogenic Responses

Jeong, H., Byun, H., Lee, J., Han, Y., Huh, S. J., & Shin, H. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400232 · Cited by 20

Extra-osseous Roles of the RANK-RANKL-OPG Axis with a Focus on Skeletal Muscle

Gostage, J., Kostenuik, P. J., Goljanek‐Whysall, K., Bellantuono, I., McCloskey, E. V., & Bonnet, N. (2024) · Current Osteoporosis Reports · doi:10.1007/s11914-024-00890-2 · Cited by 21

New Function of Cholesterol Oxidation Products Involved in Osteoporosis Pathogenesis

Che, Y., Yang, J., Tang, F., Wei, Z., Chao, Y., Li, N., Li, H., Wu, S., & Dong, X. W. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042020 · Cited by 20

Urolithin B suppresses osteoclastogenesis via inhibiting RANKL‐induced signalling pathways and attenuating ROS activities

Qu, Z., An, H., Feng, M., Huang, W., Wang, D., Zhang, Z., & Yan, L. W. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17467 · Cited by 20

Dual-functional composite hydrogel platform: A “kill two birds with one stone” strategy for anti-infection and osseointegration in the treatment of infectious bone defects

Shi, X., Wu, Y., Tang, L., Yin, Z., Shi, J. Y., Wu, X., & Xu, Y. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.155337 · Cited by 19

Porous 3D Scaffolds Enhance MSC Vitality and Reduce Osteoclast Activity

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Bone and the Unfolded Protein Response: In Sickness and in Health

Iyer, S. V., & Adams, D. J. (2023) · Calcified Tissue International · doi:10.1007/s00223-023-01096-x · Cited by 18

Osteoimmunology of Spondyloarthritis

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HSP90 Exacerbates Bone Destruction in Rheumatoid Arthritis by Activating TRAF6/NFATc1 Signaling

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Osteoclast-poor osteopetrosis

Sobacchi, C., & Abinun, M. (2022) · Bone · doi:10.1016/j.bone.2022.116541 · Cited by 18

Current progress of plant-derived exosome-like nanovesicles on the regulation of osteoporosis and osteoarthritis

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Fibronectin-LILRB4/gp49B interaction negatively regulates osteoclastogenesis through inhibition of RANKL-induced TRAF6/TAK1/NF–kB/MAPK signaling

Su, M., Ono, K., Kezuka, D., Miyamoto, S., Mori, Y., & Takai, T. (2022) · International Immunology · doi:10.1093/intimm/dxac051 · Cited by 16

IL-6 Plays a Critical Role in Stromal Fibroblast RANKL Induction and Consequent Osteoclastogenesis in Ameloblastoma Progression

Yoshimoto, S., Morita, H., Okamura, K., Hiraki, A., & Hashimoto, S. (2023) · Laboratory Investigation · doi:10.1016/j.labinv.2022.100023 · Cited by 16

Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis

Ma, Q., Wang, S., Xue, H., Ni, L., Yuan, P., Shen, Y., Zheng, B., Wang, Q., Zhang, J., Wang, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61938-0 · Cited by 16

CSTA plays a role in osteoclast formation and bone resorption by mediating the DAP12/TREM2 pathway

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Strategies for Cartilage Repair in Osteoarthritis Based on Diverse Mesenchymal Stem Cells‐Derived Extracellular Vesicles

Huang, S. ‐., Liu, Y., Wang, C., Xiang, W., Wang, N., Peng, L., Jiang, X., Zhang, X., & Fu, Z. (2023) · Orthopaedic Surgery · doi:10.1111/os.13848 · Cited by 15

Cooperation between T and B cells reinforce the establishment of bone metastases in a mouse model of breast cancer

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Sorting Nexin 10 as a Key Regulator of Membrane Trafficking in Bone-Resorbing Osteoclasts: Lessons Learned From Osteopetrosis

Elson, A., Stein, M., Rabie, G., Barnea, M., Winograd-Katz, S. E., Reuven, N. B., Shalev, M., Sekereš, J., Kanaan, M. N., Tuckermann, J. P., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.671210 · Cited by 15

Regulation of osteoclast-mediated bone resorption by lipids

Luo, F., Chen, T., Chen, S., Bai, D., & Li, X. (2025) · Bone · doi:10.1016/j.bone.2025.117423 · Cited by 13

Age-related alterations of angiogenesis, inflammation and bone microarchitecture during fracture healing in mice

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Roles and mechanisms of optineurin in bone metabolism

Jin, J., Huang, R., Chang, Y., & Yi, X. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116258 · Cited by 14

The Neuropeptide VIP Limits Human Osteoclastogenesis: Clinical Associations with Bone Metabolism Markers in Patients with Early Arthritis

Castro, D. M., Lamana, A., Arribas‐Castaño, P., Gutiérrez‐Cañas, I., Villanueva‐Romero, R., Pérez‐García, S., Martínez, C., Juarranz, Y., de Córdoba‐Oñate, S. F., González‐Álvaro, I., et al. (2021) · Biomedicines · doi:10.3390/biomedicines9121880 · Cited by 11

Traditional Chinese decoction Si Zhi Wan attenuates ovariectomy (OVX)-induced bone loss by inhibiting osteoclastogenesis and promoting apoptosis of mature osteoclasts

He, Q., Fu, K., Yao, H., Wei, S., Li, X., Liu, S., Chen, T., & Gao, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.983884 · Cited by 11

Bone Formation and Maintenance in Oral Surgery: The Decisive Role of the Immune System—A Narrative Review of Mechanisms and Solutions

Choukroun, É., Parnot, M., Surmenian, J., Gruber, R., Cohen, N., Davido, N., Simonpieri, A., Savoldelli, C., Afota, F., Mjabber, H. E., et al. (2024) · Bioengineering · doi:10.3390/bioengineering11020191 · Cited by 13

Macrophages and osteoclasts: similarity and divergence between bone phagocytes

Halper, J., Dolfi, B., Ivanov, S., Madel, M., & Blin‐Wakkach, C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1683872 · Cited by 12

FTY720 Attenuates LPS-Induced Inflammatory Bone Loss by Inhibiting Osteoclastogenesis via the NF-κB and HDAC4/ATF Pathways

Chen, C., Zong, S., Wang, Z., Yang, R., Guo, Y., Wang, Y., Chen, X., Li, Y., & Wang, S. (2023) · Journal of Immunology Research · doi:10.1155/2023/8571649 · Cited by 12

Role of MOTS-c in the regulation of bone metabolism

Yi, X., Hu, G., Yang, Y., Li, J., Jin, J., & Chang, B. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1149120 · Cited by 10

FAM19A5 in vascular aging and osteoporosis: Mechanisms and the “calcification paradox”

Zheng, J., He, J., & Li, H. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102361 · Cited by 10

A microenvironment responsive nanoparticle regulating osteoclast fate to promote bone repair in osteomyelitis

Zeng, H., Li, D., He, Q., Zheng, X., Chen, X., Jian, G., Zhang, H., & Chen, T. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101777 · Cited by 10

Pathogenesis, assessment, and management of bone loss in axial spondyloarthritis

Nakamura, A., & Towheed, T. (2023) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2023.152345 · Cited by 11

The Biological Properties of Co‐Doped Monetite Are Influenced by Thermal Treatment

de Almeida, G. S., Suter, L. C., Pinto, T. S., Carra, M. G. J., Feltran, G. D. S., de Moraes, J. F., Corrêa, D. R. N., Saeki, M. J., Lisboa‐Filho, P. N., & Zambuzzi, W. F. (2025) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35531 · Cited by 9

Rare coding variants in NOX4 link high ROS levels to psoriatic arthritis mutilans

Wang, S., Nikamo, P., Laasonen, L., Guðbjörnsson, B., Ejstrup, L., Iversen, L., Lindqvist, U. R. C., Alm, J. J., Eisfeldt, J., Zheng, X., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00035-z · Cited by 9

Dantrolene, a stabilizer of the ryanodine receptor, prevents collagen-induced arthritis

Nawata, T., Sakai, H., Honda, T., Otsuka, M., Fujita, H., Uchinoumi, H., Kobayashi, S., Yamamoto, T., Asagiri, M., & Yano, M. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.07.111 · Cited by 9

Anti‐Inflammatory and Anti‐Osteoclastogenesis Activities of Different Kinds of Zanthoxylum bungeanum Seed Oil in Vitro

Zhang, B., Luo, S., Wu, S., Li, J., He, F., Luo, R., Wu, Y., Pan, M., Yong, L., & Pei, X. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202201157 · Cited by 9

Opposite Roles of IL-32α Versus IL-32β/γ Isoforms in Promoting Monocyte-Derived Osteoblast/Osteoclast Differentiation and Vascular Calcification in People with HIV

Ramani, H., Cleret‐Buhot, A., Sylla, M., Bunet, R., Bertrand, F., Peet, M.-M., Chartrand‐Lefebvre, C., Trottier, B., Thomas, R., Routy, J., et al. (2025) · Cells · doi:10.3390/cells14070481 · Cited by 9

Nanohydroxyapatite-Stabilized Pickering-Emulsion-Incorporated Hydrogel Prevents Postoperative Osteosarcoma Recurrence and Promotes Bone Repair

Zhang, Y., Wang, Y., Zhang, X., Yue, L., Yang, L., Lai, H., Yang, C., & Huang, Y. (2025) · Nano Letters · doi:10.1021/acs.nanolett.5c01949 · Cited by 8

Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis

Garcia-Hernandez, M. D. L. L., Rangel-Moreno, J., García-Castañeda, M., Kenney, H., Paine, A., Thullen, M., Anandarajah, A., Schwarz, E., Dirksen, R., & Ritchlin, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1026574 · Cited by 9

Beclin 1 positively regulates osteoprotegerin-induced inhibition of osteoclastogenesis by increasing autophagy in vitro

Tong, X., Min, W., Li, S., Chen, M., Song, R., Bian, J., Gu, J., & Liu, Z. (2021) · Differentiation · doi:10.1016/j.diff.2021.08.003 · Cited by 8

Effect of cadmium on Rho GTPases signal transduction during osteoclast differentiation

He, S., Zhang, K., Cao, Y., Liu, G., Zou, H., Song, R., & Liu, Z. (2022) · Environmental Toxicology · doi:10.1002/tox.23510 · Cited by 8

Casticin suppresses RANKL‑induced osteoclastogenesis and prevents ovariectomy‑induced bone loss by regulating the AKT/ERK and NF‑κB signaling pathways

Yang, F., Su, Y., Liang, J., Wang, K., Lian, H., Chen, J., Xu, J., Zhao, J., & Liu, Q. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5246 · Cited by 8

Correlation between CBC-derived inflammatory indicators and all-cause mortality with rheumatoid arthritis: a population-based study

Liu, J., Liu, Y., Fan, S., Yang, J., Xu, M., Zhao, L., Liu, C., Xing, Y., & Kong, X. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1538710 · Cited by 7

Aikeqing, a kidney- and spleen-tonifying compound Chinese medicine granule, prevented ovariectomy-induced bone loss in rats via the suppression of osteoclastogenesis

Liu, Z., Xi, X.-L., Wu, T.-R., Lu, Y., Zhong, P., Hu, Y., & Shen, X. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115339 · Cited by 7

The Therapeutic Effect of Natural Compounds on Osteoporosis through Ferroptosis

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A novel Glycyrrhiza glabra extract liquiritin targeting NFATc1 activity and ROS levels to counteract ovariectomy-induced osteoporosis and bone loss in murine model

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