The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
RANKL as the master regulator of osteoclast differentiation
Abstract
RANKL, the essential cue for osteoclast differentiation, is the membrane-bound factor expressed by osteoclastogenesis-supporting cells such as osteoblasts and osteocytes. In vivo evidence indicates that RANKL functions as the indispensable and irreplaceable in the program of osteoclast differentiation. The reason why RANKL plays a critical role in osteoclastogenesis is discussed from the viewpoint of the distinct signaling pathways mediated by co-stimulatory receptors and the key transcription factor NFATc1.
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“Mechanistically, M-CSF and RANKL bind to their receptors CSF1R and RANK, respectively, and stimulate downstream signaling pathways such as MAPKs and NF-κB, leading to the activation of master transcription factors including PU.1 and NFATc1, initiating osteoclastogenesis9,10.”
From Targeting Msx2 as a brake in the fusion fate of osteoclasts and an anabolic therapy in pre-clinical models of osteoporosis (2025) · cites this paper as [10]
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Metadata
- Authors
- Takayanagi, H.
- Affiliations
- The University of Tokyo (JP)
- Corresponding author
- Takayanagi, Hiroshi
- ORCID
- Takayanagi, Hiroshi
- Venue
- Journal of Bone and Mineral Metabolism
- Published
- 2021-01
- Volume
- 39
- Issue
- 1
- Pages
- 13-18
- ISSN
- 0914-8779 (ISSN-L)
- 1435-5604
- OpenAlex
- W3116940347
- Cited by
- 175
- References
- 43
- Citations by year
- 2026: 29 · 2025: 38 · 2024: 35 · 2023: 38 · 2022: 25 · 2021: 9
- FWCI
- 2.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Bone and Mineral Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (20F20730)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Rheumatology › Osteomyelitis and Bone Disorders Research
- Keywords
- RANKL, osteoclastogenesis, RANK receptor, costimulatory receptors, NFATc1, transcription factor signaling, osteoblasts, osteocytes, bone remodeling
- MeSH terms
- Animals, Humans, Osteoblasts, Osteoclasts, Osteogenesis, Signal Transduction, NFATC Transcription Factors, RANK Ligand
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