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Cited by 14Pituitary Gland Disorders and TreatmentsBone health and osteoporosis researchGrowth Hormone and Insulin-like Growth Factors

Various risks of osteoporosis in patients with pituitary adenomas

Matsuyama, Junko, Eshima, Nobuoki, Fukunaga, Tsutana, Hori, Shigeaki, Kobayashi, Hidenori, Isono, Mitsuo·2003·Journal of Bone and Mineral Metabolism
DOI 10.1007/s007740300015
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Abstract

Some pituitary adenomas seem to be related to bone loss. It is unknown what kinds of pituitary adenomas affect bone mass. We attempted to determine what kinds of pituitary adenomas caused osteoporosis, and whether hormonal disturbance in pituitary adenoma patients affected bone mass. This study included 53 surgical patients (39 women of premenopausal age and 14 men) aged 21 to 62 years. We measured vertebral bone mineral density (BMD); various bone metabolic parameters, such as serum calcium, phosphorus, alkaline phosphatase, and blood urea nitrogen, parathormone, vitamin D, vitamin K, and hormonal activity in the anterior lobe of the pituitary gland. Comparisons were made of the mean Z scores (the ratio to the mean BMD of age-matched healthy Japanese women and men) among patient groups and controls. Compared with the female controls, the mean Z score was significantly higher in the women with acromegalic adenoma and significantly lower in those with adrenocorticotrophic hormone (ACTH)-secreting adenoma. In male patients, the mean Z scores were significantly decreased in prolactin-secreting adenoma and nonfunctioning adenoma, compared with that in normal controls. Acromegalic adenoma contributes significantly to vertebral bone mass acquisition, although ACTH adenoma may carry a significant risk of osteoporosis in female patients. Male patients with prolactin-secreting and nonfunctioning adenoma have a significant risk of bone decrease.

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Crossref · 10.1007/s007740300015

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  • Increase in bone resorption and low BMD occur in males and females with hyperprolactinemia.

    “Increase in bone resorption and low BMD occur in males and females with hyperprolactinemia [18, 20–23].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [23]

  • Patients with acromegaly generally demonstrate increased cortical bone mass, whereas trabecular BMD is more variable.

    “Patients with acromegaly generally demonstrate increased cortical bone mass, whereas trabecular BMD is more variable [23, 35, 41, 42].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [23]

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Authors
Matsuyama, J., Eshima, N., Fukunaga, T., Hori, S., Kobayashi, H., & Isono, M.
Affiliations
Beppu Medical Center (JP)
ORCID
Eshima, Nobuoki
Venue
Journal of Bone and Mineral Metabolism
Publisher
Springer Science and Business Media LLC
Published
2003-03-01
Volume
21
Issue
2
Pages
91-97
ISSN
  • 0914-8779 (ISSN-L)
  • 1435-5604
DOI
10.1007/s007740300015
OpenAlex
W2069995923
Cited by
14
References
20
Citations by year
2022: 1 · 2021: 1 · 2018: 2 · 2015: 2 · 2014: 2 · 2012: 1
FWCI
0.41
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Bone and Mineral Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
osteoporosis, pituitary adenoma, bone mineral density, vertebral bone loss, ACTH-secreting tumor, prolactinoma, non-functioning pituitary adenoma, bone metabolism, sex differences, Z-score
MeSH terms
Adenoma, Adrenocorticotropic Hormone, Adult, Aging, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Osteoporosis, Pituitary Neoplasms, Prolactin, Reference Values, Bone Density, Premenopause, Risk Assessment, Human Growth Hormone

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