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Cited by 62Bone health and osteoporosis researchPituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth Factors

Prevalence of osteopenia in men with prolactinoma

Naliato, E. C. O., Farias, M. L. F., Braucks, G. R., Costa, F. S. R., Zylberberg, D., Violante, A. H. D.·2005·Journal of Endocrinological Investigation
DOI 10.1007/bf03345523
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Abstract

The aim of this cross-sectional study was to analyze bone mineral density (BMD) and prevalence of osteopenia and osteoporosis in 30 men with prolactinoma, and compare them to 22 control subjects. BMD of lumbar spine and femur was evaluated by dual-energy X-ray absorptiometry. PRL, testosterone, estradiol, sexual hormone-binding globulin and free androgen and estrogen indexes (FAI and FEI, respectively) were measured in all the subjects. In patients with prolactinoma, mean values of PRL and testosterone were calculated for the 12-month period that preceded the study. The mean T-score of the four sites analyzed by bone densitometry was lower in men with prolactinoma than in controls (p-values: lumbar spine=0.015, femoral neck <0.0001, trochanter=0.037, total femur=0.036), and 55.6% of the former presented osteopenia or osteoporosis at one or more sites (p =0.035). The lumbar spine was the most seriously affected site, where 29.6% had osteopenia and 14.8% had osteoporosis. By the time of BMD determination, significant associations were found between BMD and PRL, testosterone, FAI, estradiol, FEI, and duration of hypogonadism. Considering the period of 12 months that preceded BMD evaluation, trochanter BMD was associated with mean PRL levels, while there was an association between lumbar spine BMD and mean testosterone levels. However, the multiple regression analysis showed that estradiol was the main determinant of BMD. In conclusion, men with prolactinoma have high prevalence…

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Crossref · 10.1007/bf03345523

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  • Patients with a longer duration of hypogonadism are likely to have lower bone density.

    “In addition, patients with a longer duration of hypogonadism are likely to have lower bone density [19, 22].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [22]

  • Increase in bone resorption and low BMD occur in males and females with hyperprolactinemia.

    “Increase in bone resorption and low BMD occur in males and females with hyperprolactinemia [18, 20–23].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [22]

  • In men with prolactinoma, the absence of detectable levels of estradiol is correlated with lower BMD in all analyzed sites.

    “In men with prolactinoma the absence of detectable levels of estradiol was correlated with lower BMD in all analyzed sites.”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [22]

  • Lumbar spine and femoral neck BMD values are negatively correlated with prolactin levels and disease duration in hyperprolactinemia.

    “A significant negative correlation was found between lumbar spine and femoral neck BMD values and both prolactin (PRL) levels and disease duration, which suggests that the duration of the disease is strongly correlated with the severity of bone loss [20, 22].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [22]

  • Patients who developed hyperprolactinemia in childhood or adolescence have more severe bone impairment than subjects who developed hyperprolactinemia in adulthood.

    “Patients who developed hyperprolactinemia in childhood or adolescence have more severe bone impairment than subjects who developed hyperprolactinemia in adulthood [20, 22].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [22]

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Authors
Naliato, E. C. O., Farias, M. L. F., Braucks, G. R., Costa, F. S. R., Zylberberg, D., & Violante, A. H. D.
Affiliations
Universidade Federal do Rio de Janeiro (BR)
Corresponding author
Naliato, E. C. O.
ORCID
Venue
Journal of Endocrinological Investigation
Publisher
Springer Science and Business Media LLC
Published
2005-03
Volume
28
Issue
3
Pages
12-17
ISSN
  • 0391-4097 (ISSN-L)
  • 1720-8386
DOI
10.1007/bf03345523
OpenAlex
W2061904122
Cited by
62
References
38
Citations by year
2025: 3 · 2024: 4 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 2
FWCI
3.86
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Journal of Endocrinological Investigation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords
prolactinoma, osteopenia, osteoporosis, bone mineral density, hyperprolactinemia, hypogonadism, testosterone, estradiol, free androgen index, bone loss, men
MeSH terms
Adolescent, Adult, Aged, Bone Diseases, Metabolic, Cross-Sectional Studies, Densitometry, Estrogens, Hormones, Humans, Hyperprolactinemia, Hypogonadism, Male, Middle Aged, Osteoporosis, Regression Analysis, Prolactinoma, Absorptiometry, Photon, Bone Density

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