The risk of osteopenia in premenopausal women with various sellar tumors
Abstract
Objective Patients with prolactinoma seem to be at high risk for osteopenia. However, whether patients with various pathological sellar tumors have risk for osteopenia remains unclear. The aim of the present study is to assess the bone mass alteration in patients with various sellar tumors and further to investigate the risk factors of bone mass alteration. Materials and methods 65 premenopausal female patients with diverse sellar tumors and 325 normal controls were enrolled in this study. Bone mineral density (BMD) of lumbar spine and comprehensive endocrinological evaluations were undergone. Results Compared to the matched controls, BMD of patients with prolactinoma or craniopharyngioma significantly decreased. Patients with sellar meningioma and nonfunctioning adenoma are with a decreasing tendency and patients with growth hormone-secreting adenoma are with an increasing tendency compared to controls. Univariate and multivariate regression analysis indicated that the bone loss in prolactinomas was significantly correlated to disease duration and hypogonadism. Conclusion In the premenopausal women, patients with prolactinoma or craniopharyngioma are often accompanied with osteopenia or osteoporosis, and disease duration and hypogonadism are the risk factors of bone loss in prolactinoma. Continuous surveillance of BMD is recommended in patients with meningioma or nonfunctioning adenoma.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Patients with prolactinomas present with osteopenia or osteoporosis, and the risk factors for bone loss are disease duration and hypogonadism.
“Authors reported that the patients with prolactinomas also presented with osteopenia or osteoporosis and the risk factors of bone loss were disease duration and hypogonadism [21].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [21]
Increase in bone resorption and low BMD occur in males and females with hyperprolactinemia.
“Increase in bone resorption and low BMD occur in males and females with hyperprolactinemia [18, 20–23].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [21]
Cites
Professor Kanis, J. A., Melton, L. J., Christiansen, C., Johnston, C. C., & Khaltaev, N. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650090802 · Cited by 3,849 · see citing works
Osteoporosis: Etiology, diagnosis, and management
(1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)80791-1 · Cited by 605 · see citing works
Saeger, W., Lüdecke, D. K., Buchfelder, M., Fahlbusch, R., QUABBE, H.-J., & Petersenn, S. (2007) · European Journal of Endocrinology · doi:10.1530/eje.1.02326 · Cited by 583 · see citing works
Reduced bone mineral density in patients with adult onset growth hormone deficiency
Holmes, S. J., Economou, G., Whitehouse, R. W., Adams, J. E., & Shalet, S. M. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.3.8126140 · Cited by 340 · see citing works
Molitch, M. E., & Russell, E. J. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-112-12-925 · Cited by 317 · see citing works
Osteoporosis in Men with Hyperprolactinemic Hypogonadism
Greenspan, S. L., NEER, R. M., Ridgway, E. C., & KLIBANSKI, A. (1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-104-6-777 · Cited by 249 · see citing works
Osteoporosis: Etiology, Diagnosis, and Management
Kleerekoper, M. (1996) · Mayo Clinic Proceedings · doi:10.4065/71.9.920-a · Cited by 135 · see citing works
Bone Marker and Bone Density Responses to Dopamine Agonist Therapy in Hyperprolactinemic Males
Di Somma, C. (1998) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.3.807 · Cited by 117 · see citing works
The Nature of the Metabolic Bone Disorder in Acromegaly
Riggs, B. L., Randall, R. V., Wahner, H. W., Jowsey, J., Kelly, P. J., & Singh, M. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-34-6-911 · Cited by 111 · see citing works
Osteopenia occurs in a minority of patients with acromegaly and is predominant in the spine
Kayath, M. J., & Vieira, J. G. H. (1997) · Osteoporosis International · doi:10.1007/bf01622293 · Cited by 75 · see citing works
Bolanowski, M., Daroszewski, J., Mędraś, M., & Zadrożna-Śliwka, B. (2005) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-005-0649-9 · Cited by 74 · see citing works
Hui, S. L., Perkins, A. J., Zhou, L., Longcope, C., Econs, M. J., Peacock, M., McClintock, C., & Johnston, C. C. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8393 · Cited by 66 · see citing works
Glezer, A., Paraíba, D. B., & Bronstein, M. D. (2008) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2007.10.003 · Cited by 66 · see citing works
Idiopathic osteoporosis in premenopausal women
Rubin, M. R., Schussheim, D. H., Kulak, C. A. M., Kurland, E. S., Rosen, C. J., Bilezikian, J. P., & Shane, E. J. (2004) · Osteoporosis International · doi:10.1007/s00198-004-1716-0 · Cited by 48 · see citing works
Volumetric Bone Mineral Density in Patients with Childhood Craniopharyngioma
Muller, H. L., Schneider, P. F., Bueb, K., Etavard-Gorris, N., Gebhardt, U., Kolb, R., & Sörensen, N. (2003) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2003-39789 · Cited by 43 · see citing works
Effects of hyperprolactinemia on osteoporotic fracture in premenopausal women
Vartej, P., Poiană, C., & Vârtej, I. (2001) · Gynecological Endocrinology · doi:10.1080/713602650 · Cited by 39 · see citing works
Female hypogonadism: evaluation of the hypothalamic–pituitary–ovarian axis
Rothman, M. S., & Wierman, M. E. (2008) · Pituitary · doi:10.1007/s11102-008-0109-3 · Cited by 35 · see citing works
Holmer, H., POPOVIC, V. M., Ekman, B., Follin, C., Siversson, A. B., & Erfurth, E. M. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0229 · Cited by 33 · see citing works
Okinaga, H., Matsuno, A., & Okazaki, R. (2005) · Endocrine Journal · doi:10.1507/endocrj.52.751 · Cited by 18 · see citing works
Factors Associated with Bone Metabolism in Acromegalic Patients: Hypogonadism and Female Gender
Tütüncü, N. B., & Erbas, T. A. (2004) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2004-820913 · Cited by 16 · see citing works
Bone mineral density and bone turnover in hyperprolactinaemia of various origins.
Zadrożna-Śliwka, B., Bolanowski, M., Kałużny, M., & Syrycka, J. (2007) · PubMed · Cited by 16 · see citing works
Various risks of osteoporosis in patients with pituitary adenomas
Matsuyama, J., Eshima, N., Fukunaga, T., Hori, S., Kobayashi, H., & Isono, M. (2003) · Journal of Bone and Mineral Metabolism · doi:10.1007/s007740300015 · Cited by 14 · see citing works
Bolanowski, M., Zadrożna-Śliwka, B., Jawiarczyk-Przybyłowska, A., & Syrycka, J. (2010) · Gynecological Endocrinology · doi:10.3109/09513591003686320 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Binder, M. D., Detraux, J., & Stubbs, B. (2016) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2016.1167873 · Cited by 79 · see citing works
Prolactinoma through the female life cycle
Eschler, D. C., Javanmard, P., Cox, K., & Geer, E. B. (2017) · Endocrine · doi:10.1007/s12020-017-1438-7 · Cited by 40 · see citing works
Pituitary Disorders and Osteoporosis
Bolanowski, M., Halupczok, J., & Jawiarczyk-Przybyłowska, A. (2015) · International Journal of Endocrinology · doi:10.1155/2015/206853 · Cited by 27 · see citing works
Association Between Antipsychotics and Osteoporosis Based on Real-World Data
Yokoyama, S., Wakamoto, S., Tanaka, Y., NAKAGAWA, C., Hosomi, K., & Takada, M. (2020) · Annals of Pharmacotherapy · doi:10.1177/1060028020913974 · Cited by 14 · see citing works
van Santen, S. S., Olsson, D. S., van den Heuvel‐Eibrink, M. M., Wijnen, M., Hammarstrand, C., Janssen, J. A. M. J. L., Johannsson, G., van der Lely, A. J., & Neggers, S. J. C. M. M. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz279 · Cited by 10 · see citing works
Maroufi, S. F., Shobeiri, P., Mohammadi, E., Azadnajafabad, S., Malekpour, M., Ghasemi, E., Rashidi, M., Moghaddam, S. S., Rezaei, N., Tehrani, Y. S., et al. (2023) · Neuroepidemiology · doi:10.1159/000533527 · Cited by 6 · see citing works
Radiofrequency echographic multi-spectrometry and prolactinoma: case report
Shutova, A. S., Dzeranova, L. K., Pigarova, E. A., Vorotnikova, S. Y., Buyvalenko, U. V., Александровна, П. М., & Kuzmin, A. G. (2024) · Obesity and metabolism · doi:10.14341/omet13197 · Cited by 2 · see citing works
Menopause and prolactin secreting tumours
Carşote, M., Valea, A., Dumitrascu, A. S., Capatina, C. A.-M., Păun, D. L., Poiană, C., & Ghemigian, A. M. (2015) · Ars medica tomitana · doi:10.1515/arsm-2015-0036
Jing, P., Zhang, Y., Yin, X., Fu, Y., Su, J., Yuan, Q., Liu, X., Zhu, X., Zhang, Z. F., Tian, Q., et al. (2026) · BMC Psychiatry · doi:10.1186/s12888-026-08396-0
Self-citationHipogonadismo femenino y enfermedad ósea
Vicente, M. R. V., Santisteban, S. S., & Fernández, A. B. (2014) · Elsevier eBooks · doi:10.1016/b978-84-9022-503-5.00014-9
- Authors
- Zhao, Y., Gan, X., Luo, P., He, Q., Guo, Q., Zhang, L., Zhang, X., Zhang, X., & Fei, Z.
- Affiliations
- Xijing Hospital (CN)
- Corresponding author
- Fei, Zhou
- Venue
- Gynecological Endocrinology
- Publisher
- Informa UK Limited
- Published
- 2012-05-04
- Volume
- 28
- Issue
- 12
- Pages
- 945-948
- ISSN
- 0951-3590 (ISSN-L)
- 1473-0766
- OpenAlex
- W1974052264
- Cited by
- 10
- References
- 23
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2020: 2 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gynecological Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fourth Military Medical University
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Keywords
- osteopenia, osteoporosis, sellar region tumors, premenopausal women, prolactinoma, craniopharyngioma, non-functioning pituitary adenoma, growth hormone-secreting pituitary adenoma, bone mineral density, hypogonadism, disease duration, bone loss risk factors
- MeSH terms
- Adenoma, Adolescent, Adult, Bone Diseases, Metabolic, China, Craniopharyngioma, Female, Humans, Hypogonadism, Meningeal Neoplasms, Meningioma, Middle Aged, Osteoporosis, Pituitary Neoplasms, Risk Factors, Time Factors, Prolactinoma, Bone Density, Premenopause, Skull Base Neoplasms, Growth Hormone-Secreting Pituitary Adenoma, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
