The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Clinical characteristics associated with the prescribing of SSRI medication in adolescents with major unipolar depression
Open accessAbstract
Unipolar major depressions (MD) emerge markedly during adolescence. National Institute for Health and Care Excellence (NICE) UK recommends psychological therapies, with accompanying selective serotonin reuptake inhibitors (SSRIs) prescribed in severe cases only. Here, we seek to determine the extent and rationale of SSRI prescribing in adolescent MD before entering a randomised clinical trial. SSRI prescribing, together with their clinical characteristics was determined in 465 adolescent patients with MD prior to receiving a standardised psychological therapy as part of the Improving mood with psychoanalytic and cognitive therapies (IMPACT) clinical trial. Overall, 88 (19 %) had been prescribed antidepressants prior to psychological treatment. The clinical correlates varied by gender: respectively, depression severity in boys and self-harming behaviours in girls. Prescribing also differed between clinical research centres. Medical practitioners consider severity of depression in boys as an indicator for antidepressant prescribing. Self-injury in girls appears to be utilised as a prescribing aid which is inconsistent with past and current revised UK NICE guidelines.
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Some evidence suggests that SSRIs, SNRIs, or ketamine may exert their influence by affecting miRNAs.
“Some evidence suggests that SSRIs, SNRIs, or ketamine may exert their influence by affecting miRNAs.249,325–328”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [326]
The Introduction and Results discuss why SSRIs were prescribed to adolescents with depression, not how the drugs act. Searches for miRNAs, microRNAs, SNRIs, and ketamine found no passage in our copy addressing the proposed mechanism. Page numbers were not available in the indexed passages. (LLM, conf=0.78)
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“5 % affecting around twice as many girls as boys and around 1 in 4 of these will have a severe clinically referable condition [2, 3].”
BackgroundGoodyer, I., Dubicka, B., Wilkinson, P., Kelvin, R., Roberts, C., Byford, S., Breen, S., Ford, C., Barrett, B., Leech, A., et al. (2007) · BMJ · doi:10.1136/bmj.39224.494340.55 · Cited by 352
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Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246
Metadata
- Authors
- Cousins, L., Whitaker, K. J., Widmer, B., Midgley, N., Byford, S., Dubicka, B., Kelvin, R., Reynolds, S., Roberts, C., Holland, F., Barrett, B., Senior, R., Wilkinson, P., Target, M., Fonagy, P., & Goodyer, I. M.
- Affiliations
- University of Cambridge (GB)
- Anna Freud Centre (GB)
- King's College London (GB)
- University of Manchester (GB)
- University of East Anglia (GB)
- Corresponding author
- Goodyer, Ian M
- ORCID
- Venue
- European Child & Adolescent Psychiatry
- Published
- 2016-04-28
- Volume
- 25
- Issue
- 12
- Pages
- 1287-1295
- ISSN
- 1018-8827 (ISSN-L)
- 1435-165X
- PMC
- PMC5102956
- OpenAlex
- W2342923433
- Cited by
- 10
- References
- 5
- Citations by year
- 2026: 1 · 2023: 3 · 2022: 1 · 2019: 2 · 2018: 1 · 2017: 2
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- European Child & Adolescent Psychiatry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, cc-by)
- Staff Publications Online (The Tavistock and Portman) (acceptedVersion)
- UEA Digital Repository (University of East Anglia) (acceptedVersion)
- Apollo (University of Cambridge) (acceptedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion, cc-by)
- Staff Publications Online (The Tavistock and Portman) (submittedVersion)
- Funders
- NIHR-HTA (06/05/01)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- adolescent depression, major depressive disorder, selective serotonin reuptake inhibitors, antidepressant prescribing, NICE guidelines, gender differences, depression severity, self-harm, IMPACT trial, psychotherapy, clinical decision-making
- MeSH terms
- Adolescent, Antidepressive Agents, Major Depressive Disorder, Depressive Disorder, Major, Female, Humans, Male, Drug Prescriptions, Surveys and Questionnaires, Severity of Illness Index, Sex Characteristics, Self-Injurious Behavior, Selective Serotonin Reuptake Inhibitors
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