The burden of musculoskeletal disease—a global perspective
Abstract
Musculoskeletal diseases are one of the major causes of disability around the world and have been a significant reason for the development of the Bone and Joint Decade. Rheumatoid arthritis, osteoarthritis and back pain are important causes of disability-adjusted-life years in both the developed and developing world. COPCORD studies in over 17 countries around the world have identified back and knee pain as common in the community and are likely to increase with the ageing population. Musculoskeletal conditions are an enormous cost to the community in economic terms, and these figures emphasise how governments need to invest in the future and look at ways of reducing the burden of musculoskeletal diseases by encouraging exercise and obesity prevention campaigns.
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Degradation of aggrecan by aggrecanases is an early event in osteoarthritic cartilage damage followed by irreversible loss of collagens.
“The degradation of aggrecan by aggrecanases has gained special interest, because it constitutes an early event in osteoarthritic cartilage damage and is followed by the irreversible loss of collagens [27].”
From Arthropod steroid hormone (20-Hydroxyecdysone) suppresses IL-1β- induced catabolic gene expression in cartilage (2015) · cites this paper as [27]
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- Authors
- Brooks, P. M.
- Affiliations
- The University of Queensland (AU)
- Corresponding author
- Brooks, Peter M.
- ORCID
- Brooks, Peter M.
- Venue
- Clinical Rheumatology
- Published
- 2006-04-12
- Volume
- 25
- Issue
- 6
- Pages
- 778-781
- ISSN
- 0770-3198 (ISSN-L)
- 1434-9949
- OpenAlex
- W2072810447
- Cited by
- 545
- References
- 20
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 10 · 2023: 15 · 2022: 22 · 2021: 29 · 2020: 48 · 2019: 32 · 2018: 36 · 2017: 41 · 2016: 42 · 2015: 34 · 2014: 40 · 2013: 28 · 2012: 36
- FWCI
- 10.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Clinical Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Rehabilitation › Musculoskeletal Disorders and Rehabilitation
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- musculoskeletal disorders, disability-adjusted life years, rheumatoid arthritis, osteoarthritis, back pain, knee pain, COPCORD, economic burden, population aging, physical activity promotion, obesity prevention, Bone and Joint Decade
- MeSH terms
- Developing Countries, Government Programs, Persons with Disabilities, Health Promotion, Humans, Musculoskeletal Diseases, Obesity, Global Health, Exercise, Health Care Costs, Cost of Illness, Developed Countries
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