Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study
Open accessAbstract
Introduction In the current study, we evaluated factors that increase the coronavirus disease (COVID-19) patient death rate by analyzing the data from two cohort hospitals. In addition, we studied whether underlying neurological diseases are risk factors for death.Methods In this retrospective cohort study, we included 103 adult inpatients (aged ≥ 18 years). We evaluated differences in demographic data between surviving and non-surviving COVID-19 patients.Results In a multivariate logistic analysis, age and the presence of chronic lung disease and Alzheimer's dementia (AD) were the only significant parameters for predicting COVID-19 non-survival (p < 0.05). However, hypertension, coronary vascular disease, dyslipidemia, chronic kidney disease, diabetes, and history of taking angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors, as well as nonsteroidal anti-inflammatory drugs (NSAIDs), were not significantly associated with the death of COVID-19 patients. The optimal cutoff value obtained from the maximum Youden index was 70 (sensitivity, 80.77%; specificity, 61.04%), and the odds ratio of non-survival increased 1.055 fold for every year of age.Conclusions Clinicians should closely monitor and manage the symptoms of COVID-19 patients who are over the age of 70 years or have chronic lung disease or AD.
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Older adults are particularly vulnerable to COVID-19 infection, especially if they are affected by comorbidities such as Alzheimer's disease.
“older adults are particularly vulnerable to COVID-19 infection (4), especially if they are affected by comorbidities such as Alzheimer's disease (AD) (5).”
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- Authors
- Hwang, J.-M., Kim, J.-H., Park, J.-S., Chang, M. C., & Park, D.
- Affiliations
- Kyungpook National University Hospital (KR)
- Kyungpook National University (KR)
- Yeungnam University College (KR)
- University of Ulsan (KR)
- Corresponding author
- Chang, Min Cheol
- Park, Donghwi
- Venue
- Neurological Sciences
- Published
- 2020-07-08
- Volume
- 41
- Issue
- 9
- Pages
- 2317-2324
- ISSN
- 1590-1874 (ISSN-L)
- 1590-3478
- PMC
- PMC7342552
- OpenAlex
- W3040825973
- Cited by
- 89
- References
- 25
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 10 · 2022: 16 · 2021: 39 · 2020: 17
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurological Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation
- National Research Foundation of Korea (NRF-2019M3E5D1A02068106, 2019M3E5D1A02068106)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Oncology › COVID-19 and healthcare impacts
- Keywords
- COVID-19 pandemic, mortality risk factors, neurological disorders, Alzheimer's dementia, chronic lung disease, age, comorbidities, ACE inhibitors, angiotensin receptor blockers, nonsteroidal anti-inflammatory drugs, chronic kidney disease, hypertension
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Age Factors, Aged, Aged, 80 and over, Female, Humans, Lung Diseases, Male, Middle Aged, Mortality, Nervous System Diseases, Pneumonia, Viral, Predictive Value of Tests, Retrospective Studies, Risk Factors, Cohort Studies, Coronavirus Infections, Republic of Korea, Pandemics
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