T-Cells in Alzheimer's Disease

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160 · see citing works

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,488 · see citing works

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) · Nature · doi:10.1038/35050110 · Cited by 1,431 · see citing works

Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

Nicoll, J. A. R., Wilkinson, D., Holmes, C., Steart, P., Markham, H., & Weller, R. O. (2003) · Nature Medicine · doi:10.1038/nm840 · Cited by 1,397 · see citing works

Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy

Moalem‐Taylor, G., Leibowitz‐Amit, R., Yoles, E., Mor, F., Cohen, I. R., & Schwartz, M. (1999) · Nature Medicine · doi:10.1038/4734 · Cited by 882 · see citing works

T CELL MEMORY

Dutton, R. W., Bradley, L. M., & Swain, S. L. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.201 · Cited by 832 · see citing works

T-cell subsets (Th1 versus Th2)

Romagnani, S. (2000) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)62426-x · Cited by 816 · see citing works

Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

Rogers, J., Luber-Narod, J., Styren, S. D., & Civin, W. H. (1988) · Neurobiology of Aging · doi:10.1016/s0197-4580(88)80079-4 · Cited by 743 · see citing works

TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice

Wyss-Coray, T., Lin, C., Yan, F., Yu, G.-Q., Rohde, M., McConlogue, L., Masliah, E., & Mucke, L. (2001) · Nature Medicine · doi:10.1038/87945 · Cited by 587 · see citing works

Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: The CERAD experience, part XV

Ellis, R. J., Olichney, J. M., Thal, L. J., Mirra, S. S., Morris, J. C., Beekly, D., & Heyman, A. (1996) · Neurology · doi:10.1212/wnl.46.6.1592 · Cited by 561 · see citing works

Cerebral Hemorrhage After Passive Anti-Aβ Immunotherapy

Pfeifer, M., Boncristiano, S., Bondolfi, L., Stalder, A., Deller, T., Staufenbiel, M., Mathews, P. M., & Jucker, M. (2002) · Science · doi:10.1126/science.1078259 · Cited by 511 · see citing works

Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases

Togo, T., Akiyama, H., Iseki, E., Kondo, H., Ikeda, K., Kato, M., Oda, T., Tsuchiya, K., & Kosaka, K. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(01)00496-9 · Cited by 481 · see citing works

Basic principles of immunological surveillance of the normal central nervous system

Hickey, W. F. (2001) · Glia · doi:10.1002/glia.1101 · Cited by 476 · see citing works

Inflammation and Alzheimer's disease pathogenesis

Rogers, J., Webster, S. D., Lue, L., Brachova, L., CIVIN, W. H., Emmerling, M. R., Shivers, B. D., Walker, D. G., & McGeer, P. L. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00115-7 · Cited by 441 · see citing works

Clinical manifestations of cerebral amyloid angiopathy–related inflammation

Eng, J. A., Frosch, M. P., Choi, K., Rebeck, G. W., & Greenberg, S. M. (2004) · Annals of Neurology · doi:10.1002/ana.10810 · Cited by 417 · see citing works

Human TH1 and TH2 Subsets: Regulation of Differentiation and Role in Protection and Immunopathology

Romagnani, S. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000236199 · Cited by 383 · see citing works

A -related angiitis: primary angiitis of the central nervous system associated with cerebral amyloid angiopathy

Scolding, N. J. (2005) · Brain · doi:10.1093/brain/awh379 · Cited by 372 · see citing works

Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease

Monsonego, A., Zota, V., Karni, A., Krieger, J. I., Bar-Or, A., Bitan, G., Budson, A. E., Sperling, R., Selkoe, D. J., & Weiner, H. L. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318104 · Cited by 367 · see citing works

Microglial Activation Resulting from CD40-CD40L Interaction After β-Amyloid Stimulation

Tan, J., Town, T., Paris, D., Mori, T., Suo, Z., Crawford, F., Mattson, M. P., Flavell, R. A., & MULLAN, M. J. (1999) · Science · doi:10.1126/science.286.5448.2352 · Cited by 351 · see citing works

Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.

Weiner, H. L., Lemere, C. A., Maron, R., Spooner, E. T., Grenfell, T. J., Mori, C., Issazadeh‐Navikas, S., Hancock, W. W., & Selkoe, D. J. (2000) · PubMed · Cited by 310 · see citing works

Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid

Cribbs, D. H. (2003) · International Immunology · doi:10.1093/intimm/dxg049 · Cited by 280 · see citing works

Antigen-independent changes in naive CD4 T cells with aging.

Linton, P. J., Haynes, L., Klinman, N. R., & Swain, S. L. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.5.1891 · Cited by 248 · see citing works

Inflammation of the brain in Alzheimer's disease: implications for therapy

McGeer, P. L., & McGeer, E. G. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.4.409 · Cited by 218 · see citing works

Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice

Tan, J., Town, T., Crawford, F., Mori, T., DelleDonne, A., Crescentini, R., Obregon, D., Flavell, R. A., & Mullan, M. J. (2002) · Nature Neuroscience · doi:10.1038/nn968 · Cited by 217 · see citing works

Th1 and Th2 cells

Dong, C., & Flavell, R. A. (2001) · Current Opinion in Hematology · doi:10.1097/00062752-200101000-00009 · Cited by 216 · see citing works

Brain Inflammation in Alzheimer Disease and the Therapeutic Implications

McGeer, E. G., & McGeer, P. L. (1999) · Current Pharmaceutical Design · doi:10.2174/1381612805666230111212056 · Cited by 198 · see citing works

Pathological CNS Autoimmune Disease Triggered by Traumatic Spinal Cord Injury: Implications for Autoimmune Vaccine Therapy

Jones, T. B., Basso, D. M., Sodhi, A., Pan, J. Z., Hart, R. P., MacCallum, R. C., Lee, S., Whitacre, C. C., & Popovich, P. G. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02690.2002 · Cited by 188 · see citing works

Characterization of cytokine production, screening of lymphocyte subset patterns and in vitro apoptosis in healthy and Alzheimer's Disease (AD) individuals

Lombardi, V., Garcı́a, M., Rey, L., & Cacabelos, R. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00046-6 · Cited by 182 · see citing works

Immune hyporesponsiveness to amyloid β-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease

Monsonego, A., Maron, R., Zota, V. E., Selkoe, D. J., & Weiner, H. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191118298 · Cited by 162 · see citing works

The Role of Helper T Cell Subsets in Autoimmune Diseases

Lafaille, J. J. (1998) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(98)00009-4 · Cited by 161 · see citing works

Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia

Becker, K. J., McCarron, R. M., Ruetzler, C. A., Laban, O., Sternberg, E. M., Flanders, K. C., & Hallenbeck, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10873 · Cited by 153 · see citing works

Reduced effectiveness of Aβ1-42 immunization in APP transgenic mice with significant amyloid deposition

Das, P., Murphy, M. P., Younkin, L. H., Younkin, S. G., & Golde, T. E. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00245-7 · Cited by 150 · see citing works

Autoantibodies to amyloid-? and Alzheimer's disease

Hyman, B. T., Smith, C. R., Buldyrev, I., Whelan, C. M., Brown, H., Tang, M., & Mayeux, R. P. (2001) · Annals of Neurology · doi:10.1002/ana.1061 · Cited by 144 · see citing works

Immune Reactions Associated With Cerebral Amyloid Angiopathy

Yamada, M., Itoh, Y., Shintaku, M., Kawamura, J., Jensson, Ó., Thorsteinsson, L., Suematsu, N., Matsushita, M., & Otomo, E. (1996) · Stroke · doi:10.1161/01.str.27.7.1155 · Cited by 125 · see citing works

CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid β‐peptide

Townsend, K. P., Town, T., Mori, T., Lue, L., Shytle, D., Sanberg, P. R., Morgan, D., Fernandez, F., Flavell, R. A., & Tan, J. (2005) · European Journal of Immunology · doi:10.1002/eji.200425585 · Cited by 121 · see citing works

Vaccination with amyloid-beta peptide induces autoimmune encephalomyelitis in C57/BL6 mice

Furlan, R. (2003) · Brain · doi:10.1093/brain/awg031 · Cited by 116 · see citing works

Autoimmunity in Alzheimer’s disease: increased levels of circulating IgGs binding Aβ and RAGE peptides

Mruthinti, S., Buccafusco, J. J., Hill, W., Waller, J. L., Jackson, T. W., ZAMRINI, E. Y., & Schade, R. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.11.001 · Cited by 113 · see citing works

Autoantibodies to Amyloid β-Peptide (Aβ) are Increased in Alzheimer's Disease Patients and Aβ Antibodies Can Enhance Aβ Neurotoxicity: Implications for Disease Pathogenesis and Vaccine Development

Nath, A., Hall, E., Tuzova, M., Dobbs, M., Jones, M., Anderson, C., Woodward, J. G., Guo, Z., Fu, W., Kryscio, R. J., et al. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:3:1:29 · Cited by 107 · see citing works

A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and β-amyloid plaques in a mouse model of Alzheimer's disease

Zhang, J., Wu, X., Qin, C., Jin, Q., Ma, S., Zhang, H., Kong, Q., Chen, D., Ba, D., & He, W. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.07.005 · Cited by 102 · see citing works

Nasal Aβ Treatment Induces Anti‐Aβ Antibody Production and Decreases Cerebral Amyloid Burden in PD‐APP Mice

Lemere, C. A., Maron, R., SPOONER, E. T., Grenfell, T. J., Mori, C., Desai, R. V., Hancock, W. W., Weiner, H. L., & Selkoe, D. J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06943.x · Cited by 101 · see citing works

Quantitative Analysis of the T Cell Repertoire that Escapes Negative Selection

Peterson, D. A., DiPaolo, R. J., Kanagawa, O., & Unanue, E. R. (1999) · Immunity · doi:10.1016/s1074-7613(00)80120-x · Cited by 100 · see citing works

Local and systemic GM-CSF increase in Alzheimer's disease and vascular dementia

Tarkowski, E., Wallin, A., Regland, B., Blennow, K., & Tarkowski, A. (2001) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2001.103003166.x · Cited by 91 · see citing works

Microglia-Mediated Nitric Oxide Cytotoxicity of T Cells Following Amyloid β-Peptide Presentation to Th1 Cells

Monsonego, A., Imitola, J., Zota, V., Oida, T., & Weiner, H. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.5.2216 · Cited by 91 · see citing works

Nasal Vaccination with β -Amyloid Peptide for the Treatment of Alzheimer's Disease

Lemere, C. A., Maron, R., Selkoe, D. J., & Weiner, H. L. (2001) · DNA and Cell Biology · doi:10.1089/10445490152717569 · Cited by 82 · see citing works

Giant cell arteritis in association with cerebral amyloid angiopathy: Immunohistochemical and molecular studies

Anders, K. H., Wang, Z. Z., Kornfeld, M., Gray, F., Soontornniyomkij, V., Reed, L. A., Hart, M. N., Menchine, M. D., Secor, D. L., & Vinters, H. V. (1997) · Human Pathology · doi:10.1016/s0046-8177(97)90196-9 · Cited by 81 · see citing works

Gene Vaccination to Bias the Immune Response to Amyloid-β Peptide as Therapy for Alzheimer Disease

Qu, B. (2004) · Archives of Neurology · doi:10.1001/archneur.61.12.1859 · Cited by 80 · see citing works

Innate Immunity, Local Inflammation, and Degenerative Disease

McGeer, P. L., & McGeer, E. G. (2002) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.29.re3 · Cited by 75 · see citing works

Reduced Th1 and enhanced Th2 immunity after immunization with Alzheimer's β-amyloid1–42

Town, T., Vendrame, M., Patel, A., Poetter, D., DelleDonne, A., Mori, T., Smeed, R., Crawford, F., Klein, T., Tan, J., et al. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00307-7 · Cited by 72 · see citing works

Defining antigen‐dependent stages of T cell migration from the blood to the central nervous system parenchyma

Archambault, A. S., Sim, J. E., Gimenez, M. A. T., & Russell, J. H. (2005) · European Journal of Immunology · doi:10.1002/eji.200425864 · Cited by 70 · see citing works

Autoimmune Responses to Amyloid Structures of Aβ(25–35) Peptide and Human Lysozyme in the Serum of Patients with Progressive Alzheimer’s Disease

Алексеевна, Г. М., Davudova, T. B., Mališauskas, M., Zamotin, V., Sewell, R. D. E., Voskresenskaya, N. I., Kostanyan, I. A., Sherstnev, V. V., & Morozova‐Roche, L. A. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000079197 · Cited by 65 · see citing works

Characterization of murine immunoglobulin G antibodies against human amyloid-β1–42

Town, T., Tan, J., Sansone, N., Obregon, D. F., Klein, T., & MULLAN, M. J. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01951-6 · Cited by 64 · see citing works

IL-2 and IL-6 secretion in dementia: correlation with type and severity of disease

Huberman, M., Sredni, B., Stern, L., Kott, E., & Shalit, F. (1995) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(95)00016-u · Cited by 62 · see citing works

CD40 signaling and Alzheimer's disease pathogenesis

Town, T., Tan, J., & MULLAN, M. J. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00044-4 · Cited by 61 · see citing works

CD40–CD40L interaction in Alzheimer's disease

Tan, J. (2002) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(02)00180-7 · Cited by 57 · see citing works

Elevated interleukin-6 secretion levels by mononuclear cells of Alzheimer's patients

Shalit, F., Sredni, B., Stern, L., Kott, E., & Huberman, M. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90003-5 · Cited by 54 · see citing works

CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease.

Tan, J., Town, T., Abdullah, L., Wu, Y., Placzek, A., Small, B., Kroeger, J., Crawford, F., Richards, D., & Mullan, M. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00309-0 · Cited by 52 · see citing works

Induction of CD40 on human endothelial cells by Alzheimer’s β-amyloid peptides

Tan, J., Town, T., Suo, Z., Wu, Y., Song, S., Kundtz, A., Kroeger, J. L., Humphrey, J., Crawford, F., & MULLAN, M. J. (1999) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00122-7 · Cited by 41 · see citing works

Immune response to Aβ-peptides in peripheral blood from patients with Alzheimer's disease and control subjects

Baril, L., Nicolàs, L. S. D. S., Croisile, B., Crozier, P., Hessler, C., Sassolas, A., McCormick, J. B., & Trannoy, E. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.10.071 · Cited by 40 · see citing works

Role of Th1 and Th2 cells in autoimmune demyelinating disease

Nagelkerken, L. M. (1998) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1998000100007 · Cited by 40 · see citing works

Induction of a Th2 immune response by co-administration of recombinant adenovirus vectors encoding amyloid β-protein and GM-CSF

Kim, H., Cao, Y., Kong, F.-K., Kampen, K. R. V., Lewis, T. L., Ma, Z., Tang, D.-C. C., & Fukuchi, K.-I. (2005) · Vaccine · doi:10.1016/j.vaccine.2004.12.015 · Cited by 39 · see citing works

Association between APOE epsilon4 allele and increased expression of CD95 on T cells from patients with Alzheimer's disease

Lombardi, V., Fernández‐Novoa, L., Etcheverrı́a, I., Seoane, S., & Cacabelos, R. (2004) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2004.26.7.863735 · Cited by 20 · see citing works

Serum auto-antibodies in Alzheimer's disease

López, O. L., Rabin, B. S., & Huff, F. J. (1991) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1991.tb04985.x · Cited by 17 · see citing works

A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and β-amyloid plaques in a mouse model of Alzheimer＇s disease

Jianmin, Zhang, X., Xiaobing, Wu, chuan, C., Qin, Q., Jin, Qi, Shibin, -, M., et al. (2006) · 中国生物学文摘 · Cited by 16 · see citing works

T-Cell Interferon Gamma Binding in Patients With Dementia of the Alzheimer Type

Bongioanni, P., Boccardi, B., Borgna, M., Castagna, M., & Mondino, C. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550160085021 · Cited by 13 · see citing works

Content of Autoantibodies to Bradykinin and β-Amyloid1-42 as a Criterion for Biochemical Differences between Alzheimer's Dementias

Myagkova, M. А., Si, G., Lermontova, N. N., Kalyn, Y. B., Селезнева, Н. Д., Zharikov, G. A., Колыхалов, И. В., Абраменко, Т. В., Serkova, T. P., & Бачурин, С. О. (2003) · Bulletin of Experimental Biology and Medicine · doi:10.1023/a:1026036829237 · Cited by 11 · see citing works

The blood-brain barrier in Alzheimer’s disease

Zenaro, E., Piacentino, G., & Constantin, G. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.007 · Cited by 767 · see citing works

Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation

Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works

The Blood-Brain Barrier in Brain Homeostasis and Neurological Diseases

Weiss, N., Miller, F., Cazaubon, S., & Couraud, P.-O. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.10.022 · Cited by 731 · see citing works

The impact of microglial activation on blood-brain barrier in brain diseases

da Fonseca, A. C. C., Matias, D., Garcia, C., Amaral, R., Geraldo, L. H., Freitas, C., & Lima, F. R. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00362 · Cited by 572 · see citing works

Inflammation in neurodegenerative diseases—An update

Amor, S., Peferoen, L. A. N., Vogel, D. Y. S., Breur, M., van der Valk, P., Baker, D., & van Noort, J. M. (2014) · Immunology · doi:10.1111/imm.12233 · Cited by 550 · see citing works

Single-cell analysis reveals T cell infiltration in old neurogenic niches

Dulken, B. W., Buckley, M. T., Navarro Negredo, P., Saligrama, N., Cayrol, R., Leeman, D. S., George, B. M., Boutet, S. C., Hebestreit, K., Pluvinage, J. V., et al. (2019) · Nature · doi:10.1038/s41586-019-1362-5 · Cited by 521 · see citing works

Inflammation, microglia, and alzheimer's disease

Cameron, B., & Landreth, G. E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.10.006 · Cited by 440 · see citing works

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

vom Berg, J., Prokop, S., Miller, K. R., Obst, J., Kälin, R. E., Lopategui-Cabezas, I., Wegner, A., Mair, F., Schipke, C. G., Peters, O., et al. (2012) · Nature Medicine · doi:10.1038/nm.2965 · Cited by 416 · see citing works

Blood–Brain Barrier Pathology in Alzheimer's and Parkinson's Disease: Implications for Drug Therapy

Desai, B. S., Monahan, A. J., Carvey, P. M., & Hendey, B. (2007) · Cell Transplantation · doi:10.3727/000000007783464731 · Cited by 339 · see citing works

IFN-γ Production by Amyloid β–Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer’s Disease

Browne, T. C., McQuillan, K., McManus, R. M., O’Reilly, J.-A., Mills, K. H. G., & Lynch, M. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1200947 · Cited by 322 · see citing works

In vitro Models of Neurodegenerative Diseases

Slanzi, A., Iannoto, G., Rossi, B., Zenaro, E., & Constantin, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00328 · Cited by 293 · see citing works

Herpes Simplex Virus Type 1 and Other Pathogens are Key Causative Factors in Sporadic Alzheimer’s Disease

Harris, S. A., & Harris, E. A. (2015) · Journal of Alzheimer's Disease · doi:10.3233/jad-142853 · Cited by 279 · see citing works

Th17 Cell-Mediated Neuroinflammation Is Involved in Neurodegeneration of Aβ1-42-Induced Alzheimer’s Disease Model Rats

Zhang, J., Ke, K., Liu, Z., Qiu, Y., & Peng, Y.-P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075786 · Cited by 235 · see citing works

CNS‐infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection‐induced neuropathic pain

Cao, L., & DeLeo, J. A. (2008) · European Journal of Immunology · doi:10.1002/eji.200737485 · Cited by 212 · see citing works

Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study

Merlini, M., Kirabali, T., Kulic, L., Nitsch, R. M., & Ferretti, M. T. (2018) · Neurodegenerative Diseases · doi:10.1159/000486200 · Cited by 209 · see citing works

High-Throughput Screening Platforms in the Discovery of Novel Drugs for Neurodegenerative Diseases

Aldewachi, H. S., Al-Zidan, R. N., Conner, M. T., & Salman, M. M. (2021) · Bioengineering · doi:10.3390/bioengineering8020030 · Cited by 209 · see citing works

CNS Infiltration of Peripheral Immune Cells: D-Day for Neurodegenerative Disease?

Rezai-Zadeh, K. P., Gate, D., & Town, T. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9166-2 · Cited by 194 · see citing works

Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer’s disease

Saresella, M., Calabrese, E., Marventano, I., Piancone, F., Gatti, A. V., Alberoni, M., Nemni, R., & Clerici, M. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.004 · Cited by 190 · see citing works

Transcriptomic profiling of microglia and astrocytes throughout aging

Pan, J., Ma, N., Yu, B., Zhang, W., & Wan, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01774-9 · Cited by 188 · see citing works

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease

Dionisio-Santos, D. A., Olschowka, J. A., & O’Banion, M. K. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1453-0 · Cited by 184 · see citing works

Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer’s disease

Landel, V., Baranger, K., Virard, I., Loriod, B., Khrestchatisky, M., Rivera, S., Benech, P., & Féron, F. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-33 · Cited by 176 · see citing works

Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte–endothelial interactions

Rossi, B., Angiari, S., Zenaro, E., Budui, S. L., & Constantin, G. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0710432 · Cited by 169 · see citing works

PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

Rustenhoven, J., Smith, A. M., Smyth, L. C., Jansson, D., Scotter, E. L., Swanson, M. E. V., Aalderink, M., Coppieters, N., Narayan, P., Handley, R., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0277-1 · Cited by 155 · see citing works

Immune profiling of Alzheimer patients

Pellicanò, M., Larbi, A., Goldeck, D., Colonna‐Romano, G., Buffa, S., Bulati, M., Rubino, G., Iemolo, F., Candore, G., Caruso, C., et al. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.11.005 · Cited by 149 · see citing works

Mitochondrial Dysfunction and Immune Activation are Detectable in Early Alzheimer's Disease Blood

Lunnon, K., Ibrahim, Z. M., Proitsi, P., Lourdusamy, A., Newhouse, S., Sattlecker, M., Furney, S. J., Saleem, M., Soininen, H. S., Kłoszewska, I., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111592 · Cited by 143 · see citing works

Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration

Henstridge, C. M., Tzioras, M., & Paolicelli, R. C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00063 · Cited by 145 · see citing works

IL-4-Induced Selective Clearance of Oligomeric β-Amyloid Peptide1–42 by Rat Primary Type 2 Microglia

Shimizu, E., Kawahara, K., Kajizono, M., Sawada, M., & Nakayama, H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6503 · Cited by 143 · see citing works

Systemic immune aberrations in Alzheimer's disease patients

Bonotis, K. S., Krikki, E., Holeva, V., Aggouridaki, C., Costa, V., & Balogiannis, S. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.10.020 · Cited by 134 · see citing works

Respiratory infection promotes T cell infiltration and amyloid-β deposition in APP/PS1 mice

McManus, R. M., Higgins, S. C., Mills, K. H. G., & Lynch, M. A. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.025 · Cited by 132 · see citing works

Th17 and Cognitive Impairment: Possible Mechanisms of Action

Cipollini, V., Anrather, J., Orzi, F., & Iadecola, C. (2019) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2019.00095 · Cited by 131 · see citing works

Blood-brain barrier integrity in the pathogenesis of Alzheimer’s disease

Huang, Z., Wong, L., Su, Y., Huang, X., Wang, N., Chen, H., & Yi, C. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100857 · Cited by 130 · see citing works

Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer’s disease: preclinical proof of concept

Maezawa, I., Nguyen, H. M., Di Lucente, J., Jenkins, D. P., Singh, V., Hilt, S., Kim, K., Rangaraju, S., Levey, A. I., Wulff, H., et al. (2018) · Brain · doi:10.1093/brain/awx346 · Cited by 125 · see citing works

CNS: Not an immunoprivilaged site anymore but a virtual secondary lymphoid organ

Negi, N., & Das, B. K. (2018) · International Reviews of Immunology · doi:10.1080/08830185.2017.1357719 · Cited by 123 · see citing works

Insights into T‐cell dysfunction in Alzheimer's disease

Dai, L., & Shen, Y. (2021) · Aging Cell · doi:10.1111/acel.13511 · Cited by 119 · see citing works

Amyloid β Interaction with Receptor for Advanced Glycation End Products Up-Regulates Brain Endothelial CCR5 Expression and Promotes T Cells Crossing the Blood-Brain Barrier

Li, M., Shang, D., Zhao, W., Li, T. X., Li, B., Fang, W., Zhu, L., Man, S., & Chen, Y. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803013 · Cited by 116 · see citing works

Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice

Kawahara, K., Suenobu, M., Yoshida, A., Koga, K., Hyodo, A., Ohtsuka, H., Kuniyasu, A., Tamamaki, N., Sugimoto, Y., & Nakayama, H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.01.049 · Cited by 113 · see citing works

Peripherally Administered Human Umbilical Cord Blood Cells Reduce Parenchymal and Vascular β -Amyloid Deposits in Alzheimer Mice

Nikolic, W. V., Hou, H., Town, T., Zhu, Y., Giunta, B. N., Sanberg, C. D., Zeng, J., Luo, D., Ehrhart, J. C., Mori, T., et al. (2008) · Stem Cells and Development · doi:10.1089/scd.2008.0018 · Cited by 114 · see citing works

The role of neutrophil granule proteins in neuroinflammation and Alzheimer’s disease

Stock, A. J., Kasus‐Jacobi, A., & Pereira, H. A. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1284-4 · Cited by 114 · see citing works

Systemic and CNS Inflammation Crosstalk: Implications for Alzheimer’s Disease

Paouri, E., & Georgopoulos, S. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190321154618 · Cited by 108 · see citing works

Th17 cells and inflammation in neurological disorders: Possible mechanisms of action

Shi, Y., Wei, B., Li, L., Wang, B., & Sun, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.932152 · Cited by 108 · see citing works

Macrophages in Alzheimer’s disease: the blood-borne identity

Gate, D., Rezai-Zadeh, K., Jodry, D., Rentsendorj, A., & Town, T. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0422-7 · Cited by 107 · see citing works

The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?

Doty, K. R., Guillot-Sestier, M.-V., & Town, T. (2015) · Brain Research · doi:10.1016/j.brainres.2014.09.008 · Cited by 104 · see citing works

CD8 + T cells and neuronal damage: direct and collateral mechanisms of cytotoxicity and impaired electrical excitability

Melzer, N., Meuth, S. G., & Wiendl, H. (2009) · The FASEB Journal · doi:10.1096/fj.09-136200 · Cited by 102 · see citing works

Increased Serum Levels of Interleukin-18, -23 and -17 in Chinese Patients with Alzheimer's Disease

Chen, J., Jiang, G., Li, Q., Zhou, Z., & Cheng, Q. H. (2014) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000360606 · Cited by 97 · see citing works

Alterations in the Peripheral Immune System in Dementia

Busse, M., Michler, E., von Hoff, F., Dobrowolny, H., Hartig, R., Frodl, T., & Busse, S. (2017) · Journal of Alzheimer’s Disease · doi:10.3233/jad-161304 · Cited by 94 · see citing works

Is Alzheimer’s disease an inflammasomopathy?

Pereira, C., Santos, A. E., Moreira, P. I., Pereira, A. C., Sousa, F. J., Cardoso, S. M., & Cruz, M. T. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100966 · Cited by 94 · see citing works

Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-α-dependent

Liu, Y.-J., Guo, D.-W., Tian, L., Shang, D.-S., Zhao, W.-D., Li, B., Fang, W.-G., Zhu, L., & Chen, Y.-H. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.03.024 · Cited by 92 · see citing works

miR-155 is involved in Alzheimer’s disease by regulating T lymphocyte function

Song, J., & Lee, J. E. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00061 · Cited by 91 · see citing works

Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study

Hwang, J.-M., Kim, J.-H., Park, J.-S., Chang, M. C., & Park, D. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04541-z · Cited by 89 · see citing works

Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells

Späni, C., Suter, T., Derungs, R., Ferretti, M. T., Welt, T., Wirth, F., Gericke, C., Nitsch, R. M., & Kulic, L. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0251-x · Cited by 88 · see citing works

Neuroprotective effects of bee venom phospholipase A2 in the 3xTg AD mouse model of Alzheimer’s disease

Ye, M., Chung, H., Lee, C., Yoon, M. S., Yu, A., Kim, J. S., Hwang, D., Shim, I., & Bae, H. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0476-z · Cited by 92 · see citing works

Could Alzheimer’s Disease Originate in the Periphery and If So How So?

Morris, G., Berk, M., Maes, M. H. J., & Puri, B. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1092-y · Cited by 83 · see citing works

Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders

Anderson, K. M., Olson, K. E., Estes, K. A., Flanagan, K., Gendelman, H. E., & Mosley, R. L. (2014) · Translational Neurodegeneration · doi:10.1186/2047-9158-3-25 · Cited by 81 · see citing works

Blockade of α4 integrins reduces leukocyte–endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer’s disease

Pietronigro, E. C., Zenaro, E., Bianca, V. D., Dusi, S., Terrabuio, E., Iannoto, G., Slanzi, A., Ghasemi, S., Nagarajan, R., Piacentino, G., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-48538-x · Cited by 80 · see citing works

The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases

Sommer, A., Winner, B., & Prots, I. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0222-8 · Cited by 80 · see citing works

Migration of blood cells to β-amyloid plaques in Alzheimer's disease

Hohsfield, L. A., & Humpel, C. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.03.002 · Cited by 79 · see citing works

Chronic Intranasal Treatment with an Anti-Aβ30-42 scFv Antibody Ameliorates Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

Cattepoel, S., Hanenberg, M., Kulic, L., & Nitsch, R. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018296 · Cited by 73 · see citing works

Double Negative (IgG ⁺ IgD ⁻ CD27 ⁻ ) B Cells are Increased in a Cohort of Moderate-Severe Alzheimer's Disease Patients and Show a Pro-Inflammatory Trafficking Receptor Phenotype

Bulati, M., Buffa, S., Martorana, A., Gervasi, F., Camarda, C., Azzarello, D. M., Monastero, R., Caruso, C., & Colonna-Romano, G. (2015) · Journal of Alzheimer’s Disease · doi:10.3233/jad-142412 · Cited by 72 · see citing works

Anti-Selectin Therapy for the Treatment of Inflammatory Diseases

Rossi, B., & Constantin, G. (2008) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152808785107633 · Cited by 66 · see citing works

Elevated Osteopontin Levels in Mild Cognitive Impairment and Alzheimer's Disease

Sun, Y., Yin, X.-S., Guo, H., Han, R.-K., He, R.-D., & Chi, L. (2013) · Mediators of Inflammation · doi:10.1155/2013/615745 · Cited by 63 · see citing works

How to Get from Here to There: Macrophage Recruitment in Alzheimers Disease

Rezai-Zadeh, K. P., Gate, D., Gowing, G., & Town, T. (2011) · Current Alzheimer Research · doi:10.2174/156720511795256017 · Cited by 64 · see citing works

Transcutaneous β-amyloid immunization reduces cerebral β-amyloid deposits without T cell infiltration and microhemorrhage

Nikolic, W. V., Bai, Y., Obregon, D. F., Hou, H., Mori, T., Zeng, J., Ehrhart, J. C., Shytle, R. D., Giunta, B. N., Morgan, D., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609377104 · Cited by 63 · see citing works

The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease

Lynch, M. A. (2014) · Immunology · doi:10.1111/imm.12156 · Cited by 64 · see citing works

Women’s Pregnancy Life History and Alzheimer’s Risk: Can Immunoregulation Explain the Link?

Fox, M. M., Berzuini, C., Knapp, L. A., & Glynn, L. M. (2018) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317518786447 · Cited by 60 · see citing works

The emerging role of neutrophils in neurodegeneration

Rossi, B., Constantin, G., & Zenaro, E. (2019) · Immunobiology · doi:10.1016/j.imbio.2019.10.014 · Cited by 59 · see citing works

Enhanced Chemokine Receptor Expression on Leukocytes of Patients with Alzheimer's Disease

Goldeck, D., Larbi, A., Pellicanò, M., Alam, I., Zerr, I., Schmidt, C., Fülöp, T., & Pawelec, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066664 · Cited by 58 · see citing works

Microglial TNF-α-Dependent Elevation of MHC Class I Expression on Brain Endothelium Induced by Amyloid-Beta Promotes T Cell Transendothelial Migration

Yang, Y.-M., Shang, D.-S., Zhao, W.-D., Fang, W.-G., & Chen, Y.-H. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1138-5 · Cited by 57 · see citing works

A potential role for the PD1/PD-L1 pathway in the neuroinflammation of Alzheimer's disease

Saresella, M., Calabrese, E., Marventano, I., Piancone, F., Gatti, A. V., Farina, E., Alberoni, M., & Clerici, M. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.004 · Cited by 55 · see citing works

Increased T-cell Reactivity and Elevated Levels of CD8+ Memory T-cells in Alzheimer’s Disease-patients and T-cell Hyporeactivity in an Alzheimer’s Disease-mouse Model: Implications for Immunotherapy

Schindowski, K., Eckert, A., Peters, J., Gorriz, C., Schramm, U., Weinandi, T., Maurer, K., Frölich, L., & Müller, W. E. (2007) · NeuroMolecular Medicine · doi:10.1007/s12017-007-8015-9 · Cited by 54 · see citing works

Imaging of Leukocyte Trafficking in Alzheimer’s Disease

Pietronigro, E. C., Zenaro, E., & Constantin, G. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00033 · Cited by 52 · see citing works

Blood-Based Biomarkers of Neuroinflammation in Alzheimer’s Disease: A Central Role for Periphery?

Angiulli, F., Conti, E., Zoia, C., Re, F. D., Appollonio, I. M., Ferrarese, C., & Tremolizzo, L. (2021) · Diagnostics · doi:10.3390/diagnostics11091525 · Cited by 54 · see citing works

Hygiene and the world distribution of Alzheimer’s disease

Fox, M. M., Knapp, L. A., Andrews, P. W., & Fincher, C. L. (2013) · Evolution Medicine and Public Health · doi:10.1093/emph/eot015 · Cited by 50 · see citing works

Dual Effects of Human Placenta-Derived Neural Cells on Neuroprotection and the Inhibition of Neuroinflammation in a Rodent Model of Parkinson’s Disease

Kim, H. W., Lee, H., Kang, J. M., Bae, S., Kim, C., Lee, S., Schwarz, J., Kim, G. J., Kim, J.-S., Cha, D. H., et al. (2018) · Cell Transplantation · doi:10.1177/0963689718766324 · Cited by 50 · see citing works

T Cells—Protective or Pathogenic in Alzheimer’s Disease?

McManus, R. M., Mills, K. H. G., & Lynch, M. A. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9612-2 · Cited by 50 · see citing works

Microglial MHC-I induction with aging and Alzheimer’s is conserved in mouse models and humans

Kellogg, C. M., Pham, K. D., Machalinski, A. H., Porter, H. L., Blankenship, H. E., Tooley, K. B., Stout, M. B., Rice, H. C., Sharpe, A. L., Beckstead, M. J., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00859-6 · Cited by 47 · see citing works

PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease

Morel, M., Couturier, J., Lafay‐Chebassier, C., Paccalin, M., & Page, G. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00849.x · Cited by 47 · see citing works

Multiple Low-Dose Infusions of Human Umbilical Cord Blood Cells Improve Cognitive Impairments and Reduce Amyloid-β-Associated Neuropathology in Alzheimer Mice

Darlington, D., Deng, J., Giunta, B. N., Hou, H., Sanberg, C. D., Kuzmin‐Nichols, N., Zhou, H., Mori, T., Ehrhart, J. C., Sanberg, P. R., et al. (2012) · Stem Cells and Development · doi:10.1089/scd.2012.0345 · Cited by 46 · see citing works

MHC-I promotes apoptosis of GABAergic interneurons in the spinal dorsal horn and contributes to cancer induced bone pain

Fu, Q., Shi, D., Zhou, Y., Zheng, H., Xiang, H., Tian, X., Gao, F., Manyande, A., Cao, F., Tian, Y., et al. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2016.09.002 · Cited by 46 · see citing works

Inhibition of PDE2 reverses beta amyloid induced memory impairment through regulation of PKA/PKG-dependent neuro-inflammatory and apoptotic pathways

Wang, L., Xiaokaiti, Y., Wang, G., Xu, X., Chen, L., Huang, X., Liu, L., Pan, J., Hu, S., Chen, Z., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08070-2 · Cited by 46 · see citing works

Alzheimer’s Disease: From Immune Homeostasis to Neuroinflammatory Condition

Cariddi, L. P., Mauri, M. F., Cosentino, M., Versino, M., & Marino, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113008 · Cited by 45 · see citing works

T cell infiltration mediates neurodegeneration and cognitive decline in Alzheimer's disease

Zeng, J., Liao, Z., Yang, H., Wang, Q., Wu, Z., Hua, F., & Zhou, Z. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106461 · Cited by 48 · see citing works

Evidence from Human and Animal Studies: Pathological Roles of CD8+ T Cells in Autoimmune Peripheral Neuropathies

Yang, M., Peyret, C., Shi, X., Siron, N., Jang, J. H., Wu, S., Fournier, S., & Zhang, J. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00532 · Cited by 45 · see citing works

DNA prime–protein boost increased the titer, avidity and persistence of anti-Aβ antibodies in wild-type mice

Davtyan, H., Mkrtichyan, M., Movsesyan, N., Petrushina, I., Mamikonyan, G., Cribbs, D. H., Agadjanyan, M. G., & Ghochikyan, A. (2009) · Gene Therapy · doi:10.1038/gt.2009.140 · Cited by 43 · see citing works

Acid-Sensing Ion Channels: Expression and Function in Resident and Infiltrating Immune Cells in the Central Nervous System

Foster, V. S., Rash, L. D., King, G. F., & Rank, M. M. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.738043 · Cited by 44 · see citing works

Alternative Aβ Immunotherapy Approaches for Alzheimers Disease

Town, T. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709787847306 · Cited by 42 · see citing works

Decreased Netrin-1 and Correlated Th17/Tregs Balance Disorder in Aβ1–42 Induced Alzheimer’s Disease Model Rats

Sun, L., Ju, T., Wang, T., Zhang, L., Ding, F., Zhang, Y., An, R., Sun, Y., Li, Y., Lu, Y., et al. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00124 · Cited by 42 · see citing works

Aβ1–42 stimulated T cells express P-PKC-δ and P-PKC-ζ in Alzheimer disease

Miscia, S., Ciccocioppo, F., Lanuti, P., Velluto, L., Bascelli, A., Pierdomenico, L., Genovesi, D., Di Siena, A., Santavenere, E., Gambi, F., et al. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.011 · Cited by 40 · see citing works

The intricate role of CCL5/CCR5 axis in Alzheimer disease

Ma, W., Liu, A., Wu, X., Gao, L., Chen, J., Wu, H., Liu, M., Fan, Y., Li, P., Yang, J., et al. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad071 · Cited by 41 · see citing works

Shared Molecular and Functional Frameworks among Five Complex Human Disorders: A Comparative Study on Interactomes Linked to Susceptibility Genes

Menon, R., & Farina, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018660 · Cited by 39 · see citing works

Association of IL-12A and IL-12B polymorphisms with Alzheimer's disease susceptibility in a Han Chinese population

Zhu, X., Tan, L., Jiang, T., Tan, M., Zhang, W., & Yu, J. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.06.026 · Cited by 39 · see citing works

Enhanced soluble CD40 ligand and Alzheimer's disease: Evidence of a possible pathogenetic role

Desideri, G., Cipollone, F., Necozione, S., Marini, C., Lechiara, M. C., Taglieri, G., Zuliani, G., Fellin, R., Mezzetti, A., di Orio, F., et al. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.10.019 · Cited by 38 · see citing works

Dementia-associated changes of immune cell composition within the cerebrospinal fluid

Busse, S., Hoffmann, J., Michler, E., Hartig, R., Frodl, T., & Busse, M. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100218 · Cited by 39 · see citing works

Can peripheral leukocytes be used as Alzheimer’s disease biomarkers?

Rezai-Zadeh, K. P., Gate, D., Szekely, C. A., & Town, T. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.118 · Cited by 37 · see citing works

Peripheral and Central Glutamate Dyshomeostasis in Neurodegenerative Disorders

Onaolapo, A. Y., & Onaolapo, O. J. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666201015161919 · Cited by 37 · see citing works

Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair

Bryson, K. J., & Lynch, M. A. (2015) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2015.10.003 · Cited by 33 · see citing works

In VivoMRI of Functionalized Iron Oxide Nanoparticles for Brain Inflammation

Tang, T., Valenzuela, A. E., Petit, F., Chow, S. S. L., Leung, K. H., Gorin, F. A., Louie, A. Y., & Dhénain, M. (2018) · Contrast Media & Molecular Imaging · doi:10.1155/2018/3476476 · Cited by 35 · see citing works

T-Lymphocyte Deficiency Exacerbates Behavioral Deficits in the 6-OHDA Unilateral Lesion Rat Model for Parkinson’s Disease

Wheeler, C. J. (2014) · Journal of Neurology & Neurophysiology · doi:10.4172/2155-9562.1000209 · Cited by 32 · see citing works

Artificial intelligence and leukocyte epigenomics: Evaluation and prediction of late-onset Alzheimer’s disease

Bahado-Singh, R. O., Vishweswaraiah, S., Aydas, B., Yılmaz, A., Metpally, R. P. R., Carey, D. J., Crist, R. C., Berrettini, W. H., Wilson, G. D., Imam, K., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248375 · Cited by 31 · see citing works

Peripheral inflammation is associated with brain atrophy and cognitive decline linked to mild cognitive impairment and Alzheimer’s disease

Liang, N., Nho, K. T., Newman, J. W. I., Arnold, M., Huynh, K., Meikle, P. J., Borkowski, K., Kaddurah‐Daouk, R., Kueider‐Paisley, A., Doraiswamy, P. M., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-67177-5 · Cited by 33 · see citing works

Neuroinflammation and β Amyloid Deposition in Alzheimer's Disease: In vivo Quantification with Molecular Imaging

Hommet, C., Mondon, K., Camus, V., Ribeiro, M. J., Beaufils, É., Arlicot, N., Corcia, P., Paccalin, M., Minier, F., Gosselin, T., et al. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000354363 · Cited by 30 · see citing works

T Cells—Protective or Pathogenic in Alzheimer’s Disease?

McManus, R. M., Mills, K. H. G., & Lynch, M. A. (2015) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-015-9612-2 · Cited by 50 · see citing works

The role of T cells in the pathogenesis and prevention of the inflammatory and neurodegenerative changes associated with Alzheimer's disease

McQuillan, K. (2009) · Arrow@dit (Dublin Institute of Technology)

Role of infection and T cells in disease pathogenesis in a model of Alzheimer's disease

McManus, R. M. (2015) · Arrow@dit (Dublin Institute of Technology)

Neuroinflammation and neuroimmunology in Alzheimer's disease: The role of T‐lymphocytes in Alzheimer's disease

Chihara, N., Tsuji, A., & Matsumoto, R. (2023) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12747 · Cited by 4 · see citing works

Insights into T‐cell dysfunction in Alzheimer's disease

Dai, L., & Shen, Y. (2021) · Aging Cell · doi:10.1111/acel.13511 · Cited by 119 · see citing works