Predictors of self-perceived health worsening over COVID-19 emergency in ALS
Open accessAbstract
Introduction Factors influencing self-perceived health status over Corona Virus Disease 2019 (COVID-19) emergency in vulnerable populations, such as patients with chronic neurological diseases, are still unknown. In this work, we aimed at testing whether clinical care changes imposed by the quarantine, together with certain demographic and disease-specific features, might have determined a self-perceived worsening of health status in patients with amyotrophic lateral sclerosis (ALS).Methods A brief web-based questionnaire investigating self-perceived anxiety, depression, and motor worsening, as well as clinical care changes over COVID-19 emergency, was administered to ALS patients currently followed at San Martino Hospital. Ordinal and logistic regression analyses were applied to identify significant predictors of health status.Results Fifty-seven ALS patients completed the questionnaire. A total of 35.08% of cases reported anxiety symptoms, 36.84% depressive symptoms, and 35.08% reported worsening of motor symptoms. Significant predictors of anxiety symptoms severity included female gender, greater motor impairment, more aggressive disease course, and rehabilitation therapy suspension. The only significant predictor of depressive symptoms severity was a more aggressive disease course. Significant predictors of motor worsening were shorter disease duration and exams/visits cancelation.Discussion COVID-19 emergency and its management exerted a significant impact on self-perceived health status in patients with ALS, particularly in those cases in the earliest disease phases and with a more aggressive disease course. These findings have potential to improve personalized medicine strategies in the next phase.
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The COVID-19 pandemic created unprecedented challenges for clinical care and research in neuromuscular disease and chronic respiratory failure patients on home invasive mechanical ventilation, who often felt abandoned.
“The COVID-19 pandemic has created unprecedented challenges for clinical care and research in NMD and CRF in HIMV who often have been feeling abandoned [20, 21], an aspect also found in caregivers [22].”
From Life Experiences in Neuromuscular Tracheotomized Patients in Times of Covid-19 (2023) · cites this paper as [20]
The Discussion reports substantial COVID-19-related disruptions to ALS clinical care and notes challenges to ALS care and research. The Results concern ALS patients, including some using noninvasive ventilation; they do not establish the claim for patients on home invasive mechanical ventilation or report that patients felt abandoned. Page numbers are unavailable in our copy. (LLM, conf=0.86)
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- Authors
- Cabona, C., Ferraro, P. M., Meo, G., Roccatagliata, L., Schenone, A., Inglese, M., Villani, F., & Caponnetto, C.
- Affiliations
- Ospedale Policlinico San Martino (IT)
- Corresponding author
- Cabona, Corrado
- ORCID
- Venue
- Neurological Sciences
- Published
- 2021-01-14
- Volume
- 42
- Issue
- 4
- Pages
- 1231-1236
- ISSN
- 1590-1874 (ISSN-L)
- 1590-3478
- PMC
- PMC7807220
- OpenAlex
- W3120230863
- Cited by
- 10
- References
- 22
- Citations by year
- 2023: 2 · 2022: 4 · 2021: 4
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurological Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Social Sciences › Psychology › Clinical Psychology › COVID-19 and Mental Health
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- amyotrophic lateral sclerosis, COVID-19 pandemic, health perception, anxiety, depression, quarantine, clinical course, disease duration
- MeSH terms
- COVID-19, Aged, Amyotrophic Lateral Sclerosis, Anxiety, Delivery of Health Care, Depression, Female, Health Status, Humans, Male, Mental Health, Middle Aged, Predictive Value of Tests, Quarantine, Surveys and Questionnaires, Self Concept, Disease Progression, Pandemics
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