Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy
Abstract
This Viewpoint from physicians with the Italian National Institute of Health confirms a higher case-fatality rate from coronavirus disease 2019 (COVID-19) in Italy compared with China and explains possible reasons, including age, cause of death definitions, and testing strategy.
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Hospitals and healthcare settings are becoming more deliriogenic because they restrict visitors, require PPE, and minimize patient interaction.
“the current state of hospitals and other healthcare settings is becoming more “deliriogenic” as they restrict visitors, require all staff members to wear personal protective equipment (PPE), and minimize patient interaction to avoid exposure [24].”
In vulnerable older adults, a change in mental status can be an early indicator of COVID-19.
“Leading authorities on delirium have found that altered mental status may be one of the first signs of COVID-19 infection among vulnerable older adults”
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- Authors
- Onder, G., Rezza, G., & Brusaferro, S.
- Affiliations
- Istituto Superiore di Sanità (IT)
- Corresponding author
- Onder, Graziano
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2020-03-23
- Volume
- 323
- Issue
- 18
- Pages
- 1775-1776
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W3012925204
- Cited by
- 4,171
- References
- 10
- Citations by year
- 2026: 13 · 2025: 77 · 2024: 163 · 2023: 316 · 2022: 643 · 2021: 1139 · 2020: 1814 · 2019: 2
- FWCI
- 127.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (University of Udine) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- COVID-19 pandemic, case fatality rate, mortality, Italy, age as risk factor, diagnostic testing strategy
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, COVID-19 Testing, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, China, Data Collection, Female, Humans, Infant, Infant, Newborn, Italy, Male, Middle Aged, Pneumonia, Viral, Population Surveillance, Sex Factors, Comorbidity, Cluster Analysis, Age Distribution, Coronavirus Infections, Clinical Laboratory Techniques, Young Adult, Pandemics, Real-Time Polymerase Chain Reaction
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