Two Cases of Fungemia due to Candida lusitaniae and a Literature Review
Abstract
Reported here are two cases of candidemia caused by Candida lusitaniae that occurred in two immunocompromised patients at Hospital Universitario "La Fe" in Valencia, Spain. Case 1 involved a low-birth-weight premature infant with congenital nephrotic syndrome who was successfully treated with amphotericin B, and case 2 involved a 50-year old woman with a high-grade malignancy lymphoma who succumbed to the infection. Antifungal susceptibility testing of the Candida lusitaniae isolates recovered from both patients revealed sensitivity to amphotericin, 5-flucytosine and fluconazole. Results are presented and discussed together with a comprehensive review of the literature, covering all previously reported cases of fungemia caused by this emerging pathogen.
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Not all C. lusitaniae isolates are resistant, but therapeutic failure of amphotericin B is well documented.
“Not all isolates are resistant [11,23,37], but therapeutic failure of amphotericin B is well documented [38].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [37]
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- Authors
- Viudes, A., Pemán, J., Cantón, E., Salavert, M., Ubeda, P., López-Ribot, J., & Gobernado, M.
- Affiliations
- Hospital Universitari i Politècnic La Fe (ES)
- Corresponding author
- Viudes, A.
- Venue
- European Journal of Clinical Microbiology and Infectious Diseases
- Published
- 2002-02-19
- Volume
- 21
- Issue
- 4
- Pages
- 294-299
- ISSN
- 0934-9723 (ISSN-L)
- 1435-4373
- OpenAlex
- W2092466374
- Cited by
- 29
- References
- 43
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2019: 4 · 2018: 3 · 2014: 2 · 2012: 2
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica
- National Institute of Allergy and Infectious Diseases (1 R29 AI42401, R29AI042401)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Candida lusitaniae, candidemia, fungemia, immunocompromised patients, preterm infants, congenital nephrotic syndrome, amphotericin B, antifungal susceptibility, 5-fluorocytosine, fluconazole, emerging fungal pathogens, lymphoma
- MeSH terms
- Amphotericin B, Antifungal Agents, Candida, Female, Humans, Infant, Newborn, Middle Aged, Opportunistic Infections, Fungemia
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