CoChat
Sign Up
Cited by 96Antifungal resistance and susceptibilityFungal Infections and StudiesNeutropenia and Cancer Infections

Candida lusitaniae: A Cause of Breakthrough Fungemia in Cancer Patients

Minari, A., Hachem, R., Raad, I.·2001·Clinical Infectious Diseases
DOI 10.1086/318473
Open this paper in CoChat — free account

Abstract

Candida lusitaniae is an infrequent cause of fungemia. We identified 12 cases of C. lusitaniae fungemia that occurred at the University of Texas M. D. Anderson Cancer Center from 1988 to 1999. The mean age of patients was 48 years (range 20--70 years). Eight patients had hematologic malignancy or had received a bone marrow transplant, and 4 had a solid tumor. Most patients (75%) were neutropenic (<10(3)/mm(3)). Treatment with amphotericin B alone failed for 3 of 6 patients, irrespective of neutropenic status. Fluconazole was effective as a single agent in 3 patients with solid tumors. The combination of amphotericin B plus fluconazole was effective treatment for two-thirds of patients with hematologic malignancy, despite persistence of neutropenia. The mortality rate associated with C. lusitaniae infection was 25%. C. lusitaniae presents as breakthrough fungemia in immunocompromised patients and is associated with failure of amphotericin B therapy. Fluconazole may be a useful agent in the treatment of this infection.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1086/318473

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Not all C. lusitaniae isolates are resistant, but therapeutic failure of amphotericin B is well documented.

    “Not all isolates are resistant [11,23,37], but therapeutic failure of amphotericin B is well documented [38].”

    From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [38]

  • Morgan et al. found that invasive aspergillosis was an uncommon complication of hematopoietic stem cell transplants (0.5% to 2.9%) and solid organ transplants (0.1% to 2.4%) at 19 U.S. transplant centers from 2001 to 2002.

    “These findings are supported by Morgan et al. (165), who found that IA was an uncommon complication of hematopoietic stem cell transplants (0.5% to 2.9%) and solid organ transplants (0.1% to 2.4%) at 19 U.S. transplant centers from 2001 to 2002.”

    From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [165]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 6

  1. Nguyen MH, Peacock JE, Morris AJ, et al. The changing face of can- didemia: emergence of non-C. albicans species and antifungal resis- tance. Am J Med 1996; 100:617-23.
  2. Clancy CJ, Nguyen MH, Yu VL, et al. Fungemia caused by Candida lusitaniae: epidemiology, clinical manifestations, therapy, and outcome. Infect Med 1996; 13:940, 948-51.
  3. Leggiardo RJ, Collins T. Postneurosurgical Candida lusitaniae men- ingitis. Pediatr Infect Dis J 1988; 7:368-9.
  4. Wendt B, Haglund L, Razavi A, et al. Candida lusitaniae: an uncommon of prostatic valve endocarditis. Clin Infect Dis 1998; 26:769-70.
  5. Pfaller MA, Barry AL. Evaluation of a novel calorimetric microbroth dilution method for antifungal susceptibility testing of yeast isolates. J Clin Microbiol 1994; 32:1992-6.
  6. Rex JH, Pfaller MA, Barry AL, et al. Antifungal susceptibility testing of isolates from a randomized, multicenter trial of fluconazole versus amphotericin B as treatment of non-neutropenic patients with can- didemia. Antimicrob Agents Chemother 1995; 39:40-4.

Cited by

Sorted by citations

Related

Authors
Minari, A., Hachem, R., & Raad, I.
Affiliations
The University of Texas MD Anderson Cancer Center (US)
Corresponding author
Raad, I.
ORCID
Hachem, R.
Venue
Clinical Infectious Diseases
Publisher
Oxford University Press (OUP)
Published
2001-01-15
Volume
32
Issue
2
Pages
186-190
ISSN
  • 1058-4838 (ISSN-L)
  • 1537-6591
DOI
10.1086/318473
OpenAlex
W2107384876
Cited by
96
References
40
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 6 · 2016: 2 · 2015: 2 · 2014: 6 · 2012: 4
FWCI
4.54
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
  • Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
Keywords
Candida lusitaniae, candidemia, cancer patients, hematologic malignancies, bone marrow transplantation, neutropenia, amphotericin B, fluconazole, combination antifungal therapy, mortality, immunocompromised patients
MeSH terms
Adult, Aged, Amphotericin B, Antifungal Agents, Candida, Candidiasis, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Neoplasms, Neutropenia, Fluconazole, Bone Marrow Transplantation, Fungemia, Immunocompromised Host, Treatment Failure, Hematologic Neoplasms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review