Contribution of serological tests and blood culture to the early diagnosis of systemic candidiasis
Abstract
The isolation of Candida species from a single blood culture is considered sufficient evidence for the initiation of systemic antifungal therapy. However, blood cultures still lack sensitivity. Previous reports have suggested that the combined serological detection of mannanemia and anti-mannan antibodies may be useful for the diagnosis of systemic candidiasis caused by Candida albicans (specificity and sensitivity 93% and 80%, respectively). In this study, serological tests to detect Candida albicans mannan and Candida albicans antibodies (Platelia Candida Antigen and Antibody tests; Bio-Rad, France) were applied retrospectively to a series of patients with at least one Candida-positive blood culture and from whom at least one serum sample, taken before or on the day of blood culture, was available. Forty-five patients were selected, including 23 infected by Candida albicans, 4 by Candida glabrata, 9 by Candida tropicalis, 5 by Candida parapsilosis, and 4 by Candida krusei. Serological tests were positive in 73% of patients at least 2 days, and in some patients, up to 15 days before blood cultures became positive. These data suggest that serological surveillance of at-risk patients using the Platelia Candida tests could result in earlier initiation of antifungal therapy, especially when used in conjunction with blood cultures. In this way, more efficient management of nosocomial infections caused by Candida species can be achieved.
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In a follow-up study of patients with candidemia, 33 of 45 (73%) had positive serology using the Platelia assay for mannan antigen or antimannan antibodies at least 2 days before a positive blood culture, with a mean positive serologic test 6 days before positive blood culture.
“A follow-up study of patients with candidemia revealed that 33 of 45 (73%) patients had positive serology using the Platelia assay for mannan antigen or antimannan antibodies at least 2 days before having a positive blood culture, with a mean positive serologic test 6 days before positive blood culture.62”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [62]
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Cites
Antimicrobial agents and chemotherapy—1969
Parker, R. H. (1971) · Journal of Chronic Diseases · doi:10.1016/0021-9681(71)90113-5 · Cited by 2,548 · see citing works
Resistance of Candida species to fluconazole
Rex, J. H., Rinaldi, M. G., & Pfaller, M. A. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.1.1 · Cited by 879 · see citing works
Hospital-Acquired Candidemia: The Attributable Mortality and Excess Length of Stay
Wey, S. B. (1988) · Archives of Internal Medicine · doi:10.1001/archinte.1988.00380120094019 · Cited by 831 · see citing works
The changing face of candidemia: emergence of non-Candida albicans species and antifungal resistance
Hong Nguyen, M., Peacock, J. E., Morris, A. J., Tanner, D. C., Nguyen, M. L., Snydman, D. R., Wagener, M. M., Rinaldi, M. G., & Yu, V. L. (1996) · The American Journal of Medicine · doi:10.1016/s0002-9343(95)00010-0 · Cited by 758 · see citing works
Predominant pathogens in hospital infections
Jarvis, W. R., & Martone, W. J. (1992) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/29.suppl_a.19 · Cited by 581 · see citing works
Importance of Candida Species Other than C. albicans as Pathogens in Oncology Patients
Wingard, J. R. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/20.1.115 · Cited by 542 · see citing works
Nosocomial Candidemia: Risk Factors and Attributable Mortality
Wenzel, R. P. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/20.6.1531 · Cited by 502 · see citing works
Nosocomial Candidiasis: Emerging Species, Reservoirs, and Modes of Transmission
Pfaller, M. A. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.supplement_2.s89 · Cited by 499 · see citing works
Rangel‐Frausto, M. S., Wiblin, T., Blumberg, H. M., Saiman, L., Patterson, J., Rinaldi, M., Pfaller, M., Edwards, Jr., Jarvis, W., Dawson, J., et al. (1999) · Clinical Infectious Diseases · doi:10.1086/520194 · Cited by 430 · see citing works
Edwards, Jr., Bodey, G. P., Bowden, R. A., Buchner, T., de Pauw, B. E., Filler, S. G., Ghannoum, M. A., Glauser, M., Herbrecht, R., Kauffman, C. A., et al. (1997) · Clinical Infectious Diseases · doi:10.1086/514504 · Cited by 418 · see citing works
Pfaller, M. A., Jones, R. N., Doern, G. V., Sader, H. S., Messer, S. A., Houston, A., Coffman, S., Hollis, R. J., & The SENTRY Participant Group (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.3.747-751.2000 · Cited by 378 · see citing works
Antibody response that protects against disseminated candidiasis
Han, Y., & Cutler, J. E. (1995) · Infection and Immunity · doi:10.1128/iai.63.7.2714-2719.1995 · Cited by 302 · see citing works
Vincent, J., Anaissie, E. J., Bruining, H. A., Demajo, W. A. P., El-Ebiary, M., Haber, J. A., Hiramatsu, Y., Nitenberg, G., Nyström, P. O., Pittet, D., et al. (1998) · Intensive Care Medicine · doi:10.1007/s001340050552 · Cited by 273 · see citing works
Sendid, B., Tabouret, M., Poirot, J. L., Mathieu, D., Fruit, J., & Poulain, D. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.5.1510-1517.1999 · Cited by 202 · see citing works
Self-citationCandidiasis: Pathogenesis, Diagnosis and Treatment
Balsdon, M. J. (1993) · Sexually Transmitted Infections · doi:10.1136/sti.69.4.326-b · Cited by 174 · see citing works
The Significance of Candidemia
ELLIS, C. A., & SPIVACK, M. L. (1967) · Annals of Internal Medicine · doi:10.7326/0003-4819-67-3-511 · Cited by 163 · see citing works
Serologic Response to Cell Wall Mannoproteins and Proteins of Candida albicans
Martínez, J. P., Gil, M. L., Lopez-Ribot, J. L., & Chaffin, W. L. (1998) · Clinical Microbiology Reviews · doi:10.1128/cmr.11.1.121 · Cited by 161 · see citing works
Han, Y., Kanbe, T., Cherniak, R., & Cutler, J. E. (1997) · Infection and Immunity · doi:10.1128/iai.65.10.4100-4107.1997 · Cited by 149 · see citing works
Nonculture methods for diagnosis of disseminated candidiasis
Reiss, E., & Morrison, C. J. (1993) · Clinical Microbiology Reviews · doi:10.1128/cmr.6.4.311 · Cited by 140 · see citing works
Occurrence of yeast bloodstream infections between 1987 and 1995 in five Dutch university hospitals
Voss, A., Kluytmans, J. A. J. W., Koeleman, J. G. M., Spanjaard, L., Vandenbroucke-Grauls, C. M. J. E., Verbrugh, H. A., Vos, M. C., Weersink, A. Y. L., Hoogkamp-Korstanje, J. A. A., & Meis, J. F. G. M. (1996) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf01690507 · Cited by 128 · see citing works
Candidiasis : pathogenesis, diagnosis, and treatment
Bodey, G. P. (1993) · Raven Press eBooks · Cited by 122 · see citing works
Detection of PCR-amplified fungal DNA by using a PCR-ELISA system
Löffler, J., Hebart, H. F., Sepe, S., et al. (1998) · Medical Mycology · doi:10.1080/02681219880000441 · Cited by 117 · see citing works
Morace, G., Pagano, L., Sanguinetti, M., Posteraro, B., Mele, L., Equitani, F., D’Amore, G., Leone, G. G. M., & Fadda, G. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.6.1871-1875.1999 · Cited by 100 · see citing works
Association of secondary and polymicrobial nosocomial bloodstream infections with higher mortality
Pittet, D., Li, N., & Wenzel, R. P. (1993) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf02000400 · Cited by 96 · see citing works
Problems in Management of Opportunistic Fungal Diseases
Armstrong, D. (1989) · Clinical Infectious Diseases · doi:10.1093/clinids/11.supplement_7.s1591 · Cited by 89 · see citing works
Duration of incubation of fungal cultures
Morris, A. J., Byrne, T., Madden, J. F., & Reller, L. B. (1996) · Journal of Clinical Microbiology · doi:10.1128/jcm.34.6.1583-1585.1996 · Cited by 83 · see citing works
Herent, P., Stynen, D., Hernando, F., Fruit, J., & Poulain, D. (1992) · Journal of Clinical Microbiology · doi:10.1128/jcm.30.8.2158-2164.1992 · Cited by 67 · see citing works
Self-citationUpdate on antifungal resistance
Klepser, M. E., Ernst, E. J., & Pfaller, M. A. (1997) · Trends in Microbiology · doi:10.1016/s0966-842x(97)01108-6 · Cited by 56 · see citing works
Harbarth, S., Ruef, C., Francioli, P. B., Widmer, A. F., & Pittet, D. (1999) · PubMed · Cited by 48 · see citing works
New perspectives in the diagnosis of systemic fungal infections
Richardson, M. D., & Kokki, M. H. (1999) · Annals of Medicine · doi:10.3109/07853899908995899 · Cited by 44 · see citing works
Fukazawa, Y. (1989) · PubMed · Cited by 29 · see citing works
Multicenter Comparison of BACTEC 9050 and BACTEC 9240 Blood Culture Systems
Murray, P. R., Hollick, G. E., Jerris, R. C., et al. (1998) · Journal of Clinical Microbiology · doi:10.1128/jcm.36.6.1601-1603.1998 · Cited by 25 · see citing works
Diagnosis of systemic candidiasis: Application of co-counterimmunoelectrophoresis
Poulain, D., Fruit, J., Fournier, L., et al. (1986) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf02075699 · Cited by 22 · see citing works
Self-citationSystemic candidiasis in a surgical intensive care unit.
Soutter, D. I., & Todd, T. R. J. (1986) · PubMed · Cited by 21 · see citing works
Cost Analysis of Candida Infection among Surgical Intensive Care Unit Patients
Goff, D. A., Sierawski, S. J., & Fass, R. J. (1996) · Clinical Drug Investigation · doi:10.2165/00044011-199612040-00002 · Cited by 20 · see citing works
Diagnosis of systemic candidiasis: Development of co-counterimmunoelectrophoresis
Poulain, D., & Pinon, J. M. (1986) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/bf02075698 · Cited by 16 · see citing works
Self-citationNonculture methods for diagnosis of disseminated candidiasis.
Reiss, E. D., & Morrison, C. J. (1993) · Clinical Microbiology Reviews · doi:10.1128/cmr.6.4.311-323.1993 · Cited by 14 · see citing works
[Therapy of systemic candidiasis].
Meunier, F. (1994) · PubMed · Cited by 4 · see citing works
Diagnosis of systemic candidiasis: Application of cocounterimmunoelectrophoresis
(1987) · Infectious Diseases Newsletter · doi:10.1016/0278-2316(87)90081-8 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Sendid B, Poirot JL, Tabouret M, Bonnin A, Caillot D, Camus D, Poulain D: Combined detection of mannanemia and anti- mannan antibodies as a strategy for the diagnosis of systemic infection caused by pathogenic Candida species. Journal of Medical Microbiology (2001) in press
- Odds FC: Candida and candidiasis. A review and bibliogra- phy. Baillière-Tindall, London (1988) pp 206-222
Cited by
Sorted by citations
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694 · see citing works
Pappas, P. G., Kauffman, C. A., Andes, D. R., Clancy, C. J., Marr, K. A., Ostrosky-Zeichner, L., Reboli, A. C., Schuster, M. G., Vazquez, J. A., Walsh, T. J., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/civ933 · Cited by 4,200 · see citing works
Epidemiology of Candida species infections in critically ill non-immunosuppressed patients
Eggimann, P., Garbino, J., & Pittet, D. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00801-6 · Cited by 900 · see citing works
Clancy, C. J., & Nguyen, M. H. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit006 · Cited by 688 · see citing works
Mikulska, M., Calandra, T., Sanguinetti, M., Poulain, D., Viscoli, C., & the Third European Conference on Infections in Leukemia Group (2010) · Critical Care · doi:10.1186/cc9365 · Cited by 319 · see citing works
Self-citationMarchetti, O., Lamoth, F., Mikulska, M., Viscoli, C., Verweij, P., Bretagne, S., & Groups, A. T. E. C. O. I. I. L. (. L. W. (2012) · Bone Marrow Transplantation · doi:10.1038/bmt.2011.178 · Cited by 275 · see citing works
Bench-to-bedside review: Candida infections in the intensive care unit
Méan, M., Marchetti, O., & Calandra, T. (2008) · Critical Care · doi:10.1186/cc6212 · Cited by 217 · see citing works
Early treatment of candidemia in adults: a review
Ostrosky-Zeichner, L., Kullberg, B. J., Bow, E. J., Hadley, S., León, C., Nucci, M., Patterson, T. F., & Perfect, J. R. (2011) · Medical Mycology · doi:10.3109/13693786.2010.512300 · Cited by 97 · see citing works
Sendid, B., Jouault, T., Coudriau, R., Camus, D., Odds, F., Tabouret, M., & Poulain, D. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.1.164-171.2004 · Cited by 69 · see citing works
Self-citationFungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting
Lepak, A., & Andes, D. (2011) · Critical Care Clinics · doi:10.1016/j.ccc.2010.11.001 · Cited by 62 · see citing works
- Authors
- Yera, H., Sendid, B., Francois, N., Camus, D., & Poulain, D.
- Affiliations
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Corresponding author
- Poulain, D.
- Venue
- European Journal of Clinical Microbiology and Infectious Diseases
- Published
- 2001-12
- Volume
- 20
- Issue
- 12
- Pages
- 864-870
- ISSN
- 0934-9723 (ISSN-L)
- 1435-4373
- OpenAlex
- W2036775339
- Cited by
- 119
- References
- 39
- Citations by year
- 2026: 1 · 2023: 4 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 3 · 2013: 7 · 2012: 3
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Clinical Microbiology & Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
- Keywords
- systemic candidiasis, Candida albicans, serological diagnosis, anti-mannan antibodies, blood culture, early diagnosis, Candida glabrata, Candida tropicalis, Candida parapsilosis, Candida krusei, nosocomial fungal infections, serological surveillance
- MeSH terms
- Candidiasis, Female, Humans, Male, Middle Aged, Serologic Tests, Fungemia
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