Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease

Ueda, Seiji; Yamagishi, Sho-ichi; Matsumoto, Yuriko; Fukami, Kei; Okuda, Seiya

doi:10.1007/s10157-007-0471-x

Cited by 65Nitric Oxide and Endothelin EffectsCancer-related gene regulationChronic Kidney Disease and Diabetes

Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease

Ueda, Seiji, Yamagishi, Sho-ichi, Matsumoto, Yuriko, Fukami, Kei, Okuda, Seiya·2007·Clinical and Experimental Nephrology

DOI 10.1007/s10157-007-0471-x

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Abstract

Endothelial dysfunction due to the reduced bioavailability of nitric oxide (NO) is involved in the course of atherosclerotic cardiovascular disease as well as chronic kidney disease (CKD). NO is synthesized from L-arginine via the action of NO synthase, which is blocked by endogenous L-arginine analogues such as asymmetric dimethylarginine (ADMA). ADMA is a naturally occurring amino acid found in plasma and various types of tissues. The plasma level of ADMA is reported to be associated with cardiovascular risk factors such as hypertension, diabetes, hyperlipidemia, and CKD, and is a strong predictor for cardiovascular disease and the progression of CKD. In this review, we discuss the biology of ADMA, the molecular mechanisms of the elevation of ADMA levels in CKD, and the pathological role of ADMA in patients with CKD.

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eNOS uncoupling due to uremic toxins including asymmetric dimethyl-arginine contributes to oxidative stress and ROS-derived kidney damage.
“As already discussed, eNOS uncoupling, due to the various uremic toxins, including asymmetric dimethyl-arginine, is a ROS contributor to oxidative stress and ROS-derived damage in the kidney (Ueda et al. 2007).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Ueda et al. 2007

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Role of Asymmetric Dimethylarginine (ADMA) in Chronic Kidney Disease
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Authors: Ueda, S., Yamagishi, S.-I., Matsumoto, Y., Fukami, K., & Okuda, S.
Affiliations: Kurume University (JP)
Corresponding author: Okuda, Seiya
ORCID: Yamagishi, Sho-ichi
Fukami, Kei
Venue: Clinical and Experimental Nephrology
Publisher: Springer Science and Business Media LLC
Published: 2007-06
Volume: 11
Issue: 2
Pages: 115-121
ISSN: 1342-1751 (ISSN-L)
1437-7799
DOI: 10.1007/s10157-007-0471-x
OpenAlex: W2028295746
Cited by: 65
References: 94
Citations by year: 2026: 3 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 3
FWCI: 0.57
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Clinical and Experimental Nephrology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords: asymmetric dimethylarginine, endothelial dysfunction, nitric oxide bioavailability, chronic kidney disease, cardiovascular risk factors, kidney injury, atherosclerotic cardiovascular disease, L-arginine analogues, NO synthase inhibition, hypertension, diabetes mellitus, hyperlipidemia
MeSH terms: Arginine, Cardiovascular Diseases, Chronic Disease, Endothelium, Vascular, Humans, Kidney Diseases, Nitric Oxide, Nitric Oxide Synthase

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Asymmetric dimethylarginine (ADMA) is a novel emerging risk factor for cardiovascular disease and the development of renal injury in chronic kidney disease

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