The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine
Abstract
Asymmetrical dimethylarginine (ADMA) is an endogenous nitric oxide synthase inhibitor, which has been suggested to be a novel independent risk factor for endothelial dysfunction and coronary heart disease. We investigated the association of ADMA concentration in serum with risk of acute coronary events. We did a prospective, nested, case-control study in middle-aged men from eastern Finland. In an analysis of men who did not smoke, those who were in the highest quartile for ADMA (>0.62 micromol/L) had a 3.9-fold (95% CI 1.25-12.3, p=0.02) increase in risk of acute coronary events compared with the other quartiles. Our findings suggest that ADMA is a predictor of acute coronary events.
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In physiology, perhaps the most common source of Fenton chemistry is the presence of increased concentrations of free iron and/or copper.
“In physiology, perhaps the most common source of Fenton chemistry is the presence of increased concentrations of free iron and/or copper (122, 458, 959).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [959]
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Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure
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Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
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Asymmetrical Dimethylarginine: The Über Marker?
Cooke, J. P. (2004) · Circulation · doi:10.1161/01.cir.0000126823.07732.d5 · Cited by 396
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The l-arginine paradox: Importance of the l-arginine/asymmetrical dimethylarginine ratio
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Amirkhizi, F., Taghizadeh, M., Hamedi-Shahraki, S., & Asghari, S. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-00932-1 · Cited by 3
“Consequently, it impairs endothelial function and promotes atherosclerosis [13].”
Metadata
- Authors
- Valkonen, V.-P., Päivä, H., Salonen, J. T., Lakka, T. A., Lehtimäki, T., Laakso, J., & Laaksonen, R.
- Affiliations
- University of Eastern Finland (FI)
- Tampere University Hospital (FI)
- University of Helsinki (FI)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 358
- Issue
- 9299
- Pages
- 2127-2128
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2166969544
- Cited by
- 562
- References
- 5
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 12 · 2020: 12 · 2019: 9 · 2018: 14 · 2017: 16 · 2016: 15 · 2015: 22 · 2014: 22 · 2013: 23 · 2012: 24
- FWCI
- 13.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer-related gene regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- asymmetric dimethylarginine, acute coronary events, coronary artery disease, endothelial dysfunction, nitric oxide synthase inhibition, serum biomarkers, cardiovascular risk factors, middle-aged men
- MeSH terms
- Arginine, Coronary Disease, Endothelium, Vascular, Humans, Male, Middle Aged, Risk Assessment
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