The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Mechanics of the brain: perspectives, challenges, and opportunities
Open accessAbstract
The human brain is the continuous subject of extensive investigation aimed at understanding its behavior and function. Despite a clear evidence that mechanical factors play an important role in regulating brain activity, current research efforts focus mainly on the biochemical or electrophysiological activity of the brain. Here, we show that classical mechanical concepts including deformations, stretch, strain, strain rate, pressure, and stress play a crucial role in modulating both brain form and brain function. This opinion piece synthesizes expertise in applied mathematics, solid and fluid mechanics, biomechanics, experimentation, material sciences, neuropathology, and neurosurgery to address today's open questions at the forefront of neuromechanics. We critically review the current literature and discuss challenges related to neurodevelopment, cerebral edema, lissencephaly, polymicrogyria, hydrocephaly, craniectomy, spinal cord injury, tumor growth, traumatic brain injury, and shaken baby syndrome. The multi-disciplinary analysis of these various phenomena and pathologies presents new opportunities and suggests that mechanical modeling is a central tool to bridge the scales by synthesizing information from the molecular via the cellular and tissue all the way to the organ level.
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Cites
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Self-citationRole of glial cells in the formation and maintenance of synapses
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A New Method to Measure Cortical Growth in the Developing Brain
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Materials and technologies for soft implantable neuroprostheses
Lacour, S. P., Courtine, G., & Guck, J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.63 · Cited by 738
Mechanical characterization of human brain tissue
Budday, S., Sommer, G., Birkl, C., Langkammer, C., Haybaeck, J., Kohnert, J., Bauer, M., Paulsen, F., Steinmann, P., Kuhl, E., et al. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.10.036 · Cited by 656
Self-citationFifty Shades of Brain: A Review on the Mechanical Testing and Modeling of Brain Tissue
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Self-citationBrain stiffness increases with myelin content
Weickenmeier, J., de Rooij, R., Budday, S., Steinmann, P., Ovaert, T. C., & Kuhl, E. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.07.040 · Cited by 264
Self-citationViscoelastic parameter identification of human brain tissue
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Metadata
- Authors
- Goriely, A., Geers, M. G. D., Holzapfel, G. A., Jayamohan, J., Jérusalem, A., Sivaloganathan, S., Squier, W., van Dommelen, J. A. W., Waters, S., & Kuhl, E.
- Venue
- Biomechanics and Modeling in Mechanobiology
- Published
- 2015-02-26
- Volume
- 14
- Issue
- 5
- Pages
- 931-965
- ISSN
- 1617-7940 (ISSN-L)
- 1617-7959
- OpenAlex
- W1994681610
- Cited by
- 371
- References
- 10
- FWCI
- 19.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Goriely, A., Geers, M. G. D., Holzapfel, G. A., Jayamohan, J., Jérusalem, A., Sivaloganathan, S., Squier, W., van Dommelen, J. A. W., Waters, S., & Kuhl, E. (2015). Mechanics of the brain: perspectives, challenges, and opportunities. Biomechanics and Modeling in Mechanobiology. https://doi.org/10.1007/s10237-015-0662-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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