Chronic Traumatic Encephalopathy in Blast-Exposed Military Veterans and a Blast Neurotrauma Mouse Model
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Blast exposure is associated with chronic traumatic encephalopathy, impaired neuronal function, and persistent cognitive deficits in blast-exposed military veterans and experimental animals.
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If there is cumulative brain damage from repetitive, sub-concussive, low-level blast exposures, it was not apparent on the study's cognitive testing.
“If there is cumulative brain damage from repetitive, sub-concussive, low-level blast exposures as evidence from other evaluation techniques suggests (Belding et al., 2021; Goldstein et al., 2012; Stone et al., 2020; Tate et al., 2013), it was not apparent on our cognitive testing.”
From Can mild traumatic brain injury alter cognition chronically? A LIMBIC-CENC multicenter study. (2023) · cites this paper as Goldstein et al., 2012
The Results report CTE neuropathology in veterans with blast exposure and/or concussive injury, supporting the cited point that other evaluation techniques suggest blast-related brain damage. But the veterans’ exposures included single blasts and blasts involving loss of consciousness, while the mouse model used a single blast; the paper does not establish cumulative damage from repetitive, sub-concussive, low-level blasts. The statement about 'our cognitive testing' is the citing authors’ own finding, not one attributed to Goldstein et al. (LLM, conf=0.88)
Experimental — accuracy not yet measuredAxonal pathology is present at all stages of CTE and becomes more severe as CTE stage advances.
“In addition to PHF-tau pathology, axonal pathology is present at all stages of CTE and becomes more severe as CTE stage advances [72, 128].”
From The neuropathology of sport (2014) · cites this paper as [72]
Despite evidence for Ab deposition in moderate to severe TBI, Ab plaques have not been found in early or mild stages of CTE in young individuals, but occur in older subjects with CTE in association with increased age at death.
“However, despite evidence for Ab deposition in moderate to severe TBI [94], Ab plaques have not been found in early or mild stages of CTE in young individuals [65, 66, 72, 91, 126] but occur in older subjects with CTE in association with increased age at death [128].”
From The neuropathology of sport (2014) · cites this paper as [72]
The local distribution of TAI to the subcortical white matter at the sulcal depths correlates with the distribution of PHF-tau pathology in the overlying cortex.
“In addition, the local distribution of TAI to the subcortical white matter at the sulcal depths correlates with the distribution of PHF-tau pathology in the overlying cortex [72].”
From The neuropathology of sport (2014) · cites this paper as [72]
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- Authors
- Goldstein, L. E., Fisher, A. M., Tagge, C. A., Zhang, X.-L., Velisek, L., Sullivan, J. A., Upreti, C., Kracht, J. M., Ericsson, M., Wojnarowicz, M. W., Goletiani, C. J., Maglakelidze, G. M., Casey, N., Moncaster, J. A., Minaeva, O., Moir, R. D., Nowinski, C. J., Stern, R. A., Cantu, R. C., Geiling, J., Blusztajn, J. K., Wolozin, B. L., Ikezu, T., Stein, T. D., Budson, A. E., Kowall, N. W., Chargin, D., Sharon, A., Saman, S., Hall, G. F., Moss, W. C., Cleveland, R. O., Tanzi, R. E., Stanton, P. K., & McKee, A. C.
- Affiliations
- Boston University (US)
- Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY 10595, USA.
- New York Medical College (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- White River Junction VA Medical Center (US)
- College of Engineering, Boston University, Boston, MA 02215, USA.
- University of Massachusetts Lowell (US)
- Lawrence Livermore National Laboratory (US)
- University of Oxford (GB)
- Corresponding author
- Goldstein, Lee E.
- McKee, Ann C.
- ORCID
- Goldstein, Lee E.
- Sullivan, John A.
- Ericsson, Maria
- Moncaster, Juliet A.
- Minaeva, Olga
- Moir, Robert D.
- Nowinski, Christopher J.
- Stern, Robert A.
- Cantu, Robert C.
- Blusztajn, Jan K.
- Wolozin, Benjamin L.
- Ikezu, Tsuneya
- Stein, Thor D.
- Budson, Andrew E.
- Kowall, Neil W.
- Cleveland, Robin O.
- Tanzi, Rudolph E.
- Stanton, Patric K.
- McKee, Ann C.
- Venue
- Science Translational Medicine
- Published
- 2012-05-16
- Volume
- 4
- Issue
- 134
- Pages
- 134ra60-134ra60
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3739428
- OpenAlex
- W2116016048
- Cited by
- 958
- References
- 89
- Citations by year
- 2026: 22 · 2025: 36 · 2024: 49 · 2023: 50 · 2022: 58 · 2021: 57 · 2020: 84 · 2019: 77 · 2018: 61 · 2017: 88 · 2016: 83 · 2015: 116 · 2014: 91 · 2013: 69 · 2012: 17
- FWCI
- 69.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 CX001038)
- National Institute on Aging (P30AG013846, P30-AG13846))
- National Institute of General Medical Sciences (GM75986, R01GM075986)
- National Institute of Allergy and Infectious Diseases (R01AI081990)
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK043881)
- National Institute of Neurological Disorders and Stroke (NS 044421, R01NS044421, NS-072966, F31NS077796, RC4NS072966, R21NS066108, R21NS073679, R01NS078337, R01NS060872, R56NS044421)
- National Institute of Environmental Health Sciences (R01ES020395)
- National Institute of Biomedical Imaging and Bioengineering (T32EB006359)
- National Center for Research Resources (S10RR026599)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Automotive and Human Injury Biomechanics
- Keywords
- chronic traumatic encephalopathy, blast exposure, traumatic brain injury, military veterans, tau phosphorylation, axonal conduction, long-term potentiation, microvasculopathy, neuroinflammation, head acceleration, concussion, postmortem neuropathology
- MeSH terms
- Acceleration, Adolescent, Adult, Animals, Axons, Behavior, Animal, Blast Injuries, Brain Concussion, Disease Models, Animal, Head, Hippocampus, Humans, Intracranial Pressure, Male, Middle Aged, Military Personnel, Synaptic Transmission, Phosphorylation, Postmortem Changes, Veterans, tau Proteins, Long-Term Potentiation, Brain Injury, Chronic, Mice, Young Adult, Athletes
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