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Cited by 151Automotive and Human Injury BiomechanicsElasticity and Material ModelingTraumatic Brain Injury Research

Biomechanics of Traumatic Brain Injury: Influences of the Morphologic Heterogeneities of the Cerebral Cortex

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Cloots, R.J.H., Gervaise, H.M.T., van Dommelen, J.A.W., Geers, M.G.D.·2008·Annals of Biomedical Engineering
DOI 10.1007/s10439-008-9510-3PMC PMC2413127
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Abstract

Traumatic brain injury (TBI) can be caused by accidents and often leads to permanent health issues or even death. Brain injury criteria are used for assessing the probability of TBI, if a certain mechanical load is applied. The currently used injury criteria in the automotive industry are based on global head kinematics. New methods, based on finite element modeling, use brain injury criteria at lower scale levels, e.g., tissue-based injury criteria. However, most current computational head models lack the anatomical details of the cerebrum. To investigate the influence of the morphologic heterogeneities of the cerebral cortex, a numerical model of a representative part of the cerebral cortex with a detailed geometry has been developed. Several different geometries containing gyri and sulci have been developed for this model. Also, a homogeneous geometry has been made to analyze the relative importance of the heterogeneities. The loading conditions are based on a computational head model simulation. The results of this model indicate that the heterogeneities have an influence on the equivalent stress. The maximum equivalent stress in the heterogeneous models is increased by a factor of about 1.3-1.9 with respect to the homogeneous model, whereas the mean equivalent stress is increased by at most 10%. This implies that tissue-based injury criteria may not be accurately applied to most computational head models used nowadays, which do not account for sulci and gyri.

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  • The patchy, perivascular location of PHF-tau pathology in sulcal depths, prominent in early CTE, is most likely related to the physics of traumatic injury and shear deformation of the brain.

    “The patchy, perivascular location of the PHF-tau pathology in sulcal depths, features prominent in early CTE, is most likely related to the physics of traumatic injury and shear deformation of the brain.”

    From The neuropathology of sport (2014) · cites this paper as [33]

  • Stress and resultant axonal injury are greatest at the interface of two tissues with differing viscoelastic properties, and the depths of cortical sulci are areas of stress concentration.

    “Stress and resultant axonal injury are greatest at the interface of two tissues with differing viscoelastic properties (such as between blood vessels and brain, or between gray and white matter) and the depths of the cortical sulci are areas of stress concentration [11, 28, 33].”

    From The neuropathology of sport (2014) · cites this paper as [33]

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Research works printed but not linked: 1

  1. [7]Claessens, M. H. A., A. A. H. J. Sauren, and J. S. H. M. Wismans. Modelling of the human head under impact conditions. In: Stapp Car Crash Conference Proceedings, Vol. 41, Warrendale, PA: Society of Automotive Engineers, Inc., 1997, pp. 315–328.

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Authors
Cloots, R. J. H., Gervaise, H. M. T., van Dommelen, J. A. W., & Geers, M. G. D.
Affiliations
Eindhoven University of Technology (NL)
Corresponding author
Cloots, R.J.H.
ORCID
Geers, M.G.D.
Venue
Annals of Biomedical Engineering
Publisher
Springer Science and Business Media LLC
Published
2008-05-09
Volume
36
Issue
7
Pages
1203-1215
ISSN
  • 0090-6964 (ISSN-L)
  • 1573-9686
DOI
10.1007/s10439-008-9510-3
PMC
PMC2413127
OpenAlex
W2133054105
Cited by
151
References
45
Citations by year
2026: 6 · 2025: 11 · 2024: 7 · 2023: 11 · 2022: 6 · 2021: 10 · 2020: 4 · 2019: 9 · 2018: 11 · 2017: 19 · 2016: 10 · 2015: 8 · 2014: 4 · 2013: 8 · 2012: 8
FWCI
5.84
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Annals of Biomedical Engineering (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • TU/e Research Portal (publishedVersion)
  • TU/e Research Portal (submittedVersion)
Funders
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek
  • Stichting voor de Technische Wetenschappen
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Automotive and Human Injury Biomechanics
  • Physical Sciences › Engineering › Biomedical Engineering › Elasticity and Material Modeling
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Keywords
traumatic brain injury, cerebral cortex, von Mises stress, finite element analysis, head kinematics
MeSH terms
Biomechanical Phenomena, Brain Injuries, Cerebral Cortex, Computer Simulation, Elasticity, Humans, Models, Neurological, Physical Stimulation, Stress, Mechanical, Weight-Bearing

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