CoChat
Sign Up
Cited by 475Exercise and Physiological ResponsesCOVID-19 Clinical Research StudiesPhysical Activity and Health

The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.

Physical exercise as a tool to help the immune system against COVID-19: an integrative review of the current literature

Open access
da Silveira, Matheus Pelinski, da Silva Fagundes, Kimberly Kamila, Bizuti, Matheus Ribeiro, Starck, Édina, Rossi, Renata Calciolari, de Resende e Silva, Débora Tavares·2021·Clinical and Experimental Medicine
DOI 10.1007/s10238-020-00650-3PMC PMC7387807
Open this paper in CoChat — free accountOpen PDF

Abstract

Acute viral respiratory infections are the main infectious disease in the world. In 2020, a new disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus disease 2019 (COVID-19), became a global pandemic. The immune response to the virus depends on factors such as genetics, age and physical state, and its main input receptor is the angiotensin-converting enzyme 2. The practice of physical exercises acts as a modulator of the immune system. During and after physical exercise, pro- and anti-inflammatory cytokines are released, lymphocyte circulation increases, as well as cell recruitment. Such practice has an effect on the lower incidence, intensity of symptoms and mortality in viral infections observed in people who practice physical activity regularly, and its correct execution must be considered to avoid damage. The initial response is given mainly by type I interferons (IFN-I), which drive the action macrophages and lymphocytes, followed by lymphocyte action. A suppression of the IFN-I response has been noted in COVID-19. Severe conditions have been associated with storms of pro-inflammatory cytokines and lymphopenia, as well as circulatory changes and virus dispersion to other organs. The practice of physical activities strengthens the immune system, suggesting a benefit in the response to viral communicable diseases. Thus, regular practice of adequate intensity is suggested as an auxiliary tool in strengthening and preparing the immune system for COVID-19. Further studies are needed to associate physical exercise with SARS-CoV-2 infection.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s10238-020-00650-3

Cites

79 of 79 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 79 references

Research works printed but not linked: 2

  1. Simpson RJ, Katsanis E. The immunological case for staying active during the COVID-19 pandemic. Brain Behav Immunity. 2020. https://doi.org/10.1016/j.bbi.2020.04.041. · DOI
  2. Elenkov IJ, Chrousos GP, Wilder RL. Neuroendocrine regulation of IL-12 and TNF-alpha/IL-10 balance. Clinical implications. Ann NY Acad Sci. 2006;917(1):94–105. https://doi.org/10.1111/j.1749-6632.2000.tb05374.x. · DOI · Paper page

Cited by

Sorted by citations

Items 301–400 of 473

Related

See all

Metadata

Authors
da Silveira, M. P., da Silva Fagundes, K. K., Bizuti, M. R., Starck, É., Rossi, R. C., & de Resende e Silva, D. T.
Affiliations
  • Universidade Federal da Fronteira Sul (BR)
  • Universidade do Oeste Paulista (BR)
ORCID
Venue
Clinical and Experimental Medicine
Publisher
Springer Science and Business Media LLC
Published
2020-07-29
Volume
21
Issue
1
Pages
15-28
ISSN
  • 1591-8890 (ISSN-L)
  • 1591-9528
DOI
10.1007/s10238-020-00650-3
PMC
PMC7387807
OpenAlex
W3045714578
Cited by
475
References
79
Citations by year
2026: 11 · 2025: 31 · 2024: 72 · 2023: 100 · 2022: 145 · 2021: 104 · 2020: 10
FWCI
11.02
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical and Experimental Medicine (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords
physical activity, COVID-19 pandemic, SARS-CoV-2, immune response, cytokines, type I interferon, lymphopenia, angiotensin-converting enzyme 2, respiratory viral infections, exercise intensity, lymphocyte circulation
MeSH terms
COVID-19, Humans, Immune System, Neutrophils, Exercise, Cytokines, Host-Pathogen Interactions

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review