Circulating endocannabinoid concentrations during orthostatic stress
Abstract
Background In animals, the endocannabinoid system is activated during hemodynamic insults and restrains blood pressure in part through sympathetic inhibition.Materials and methods We tested the hypothesis that hemodynamic stress elicited by head-up tilt testing increases systemic endocannabinoid concentrations in humans and that excessive endocannabinoid availability predisposes to presyncope.Results With head-up tilt, 2-arachidonoylglycerol increased, whereas anandamide remained unchanged.Conclusions In contrast to our expectations, anandamide plasma concentration at rest was directly correlated with orthostatic tolerance, rather than intolerance.
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Baseline concentrations of AEA affected reflex responses to orthostatic stress.
“in the second, baseline concentrations of AEA affected reflex responses to orthostatic stress (Schroeder et al, 2009).”
From Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans (2012) · cites this paper as Schroeder et al, 2009
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- Authors
- Schroeder, C., Batkai, S., Engeli, S., Tank, J., Diedrich, A., Luft, F. C., & Jordan, J.
- Affiliations
- Max Delbrück Center (DE)
- Medizinische Hochschule Hannover (DE)
- Vanderbilt University (US)
- Corresponding author
- Jordan, Jens
- Venue
- Clinical Autonomic Research
- Published
- 2009-09-15
- Volume
- 19
- Issue
- 6
- Pages
- 343-346
- ISSN
- 0959-9851 (ISSN-L)
- 1619-1560
- OpenAlex
- W1970406382
- Cited by
- 26
- References
- 14
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Clinical Autonomic Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- National Heart, Lung, and Blood Institute (P01HL056693)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- endocannabinoid system, orthostatic stress, head-up tilt, 2-arachidonoylglycerol, anandamide, orthostatic tolerance, presyncope, blood pressure regulation, sympathoinhibition
- MeSH terms
- Adult, Arachidonic Acids, Blood Pressure, Dizziness, Female, Glycerides, Humans, Male, Stress, Physiological, Sympathetic Nervous System, Syncope, Tilt-Table Test, Polyunsaturated Alkamides, Orthostatic Intolerance, Cannabinoid Receptor Modulators, Endocannabinoids
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