Cited by 26Cannabis and Cannabinoid ResearchCardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic Control

Circulating endocannabinoid concentrations during orthostatic stress

Schroeder, Christoph, Batkai, Sandor, Engeli, Stefan, Tank, Jens, Diedrich, André, Luft, Friedrich C., Jordan, Jens·2009·Clinical Autonomic Research

Abstract

Background In animals, the endocannabinoid system is activated during hemodynamic insults and restrains blood pressure in part through sympathetic inhibition.Materials and methods We tested the hypothesis that hemodynamic stress elicited by head-up tilt testing increases systemic endocannabinoid concentrations in humans and that excessive endocannabinoid availability predisposes to presyncope.Results With head-up tilt, 2-arachidonoylglycerol increased, whereas anandamide remained unchanged.Conclusions In contrast to our expectations, anandamide plasma concentration at rest was directly correlated with orthostatic tolerance, rather than intolerance.

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Crossref · 10.1007/s10286-009-0026-1

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14 of 14 references verified0 citation errors · 0 not checkable

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Authors
Schroeder, C., Batkai, S., Engeli, S., Tank, J., Diedrich, A., Luft, F. C., & Jordan, J.
Affiliations
  • Max Delbrück Center (DE)
  • Medizinische Hochschule Hannover (DE)
  • Vanderbilt University (US)
Corresponding author
Jordan, Jens
Venue
Clinical Autonomic Research
Published
2009-09-15
Volume
19
Issue
6
Pages
343-346
ISSN
  • 0959-9851 (ISSN-L)
  • 1619-1560
OpenAlex
W1970406382
Cited by
26
References
14
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 1 · 2014: 1 · 2013: 1 · 2012: 2
FWCI
1.92
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Autonomic Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft
  • Bundesministerium für Bildung und Forschung
  • National Heart, Lung, and Blood Institute (P01HL056693)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
endocannabinoid system, orthostatic stress, head-up tilt, 2-arachidonoylglycerol, anandamide, orthostatic tolerance, presyncope, blood pressure regulation, sympathoinhibition
MeSH terms
Adult, Arachidonic Acids, Blood Pressure, Dizziness, Female, Glycerides, Humans, Male, Stress, Physiological, Sympathetic Nervous System, Syncope, Tilt-Table Test, Polyunsaturated Alkamides, Orthostatic Intolerance, Cannabinoid Receptor Modulators, Endocannabinoids

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