Orthostatic heart rate responses after prolonged space flights
Abstract
Orthostatic tachycardia (POTS) can occur after space flights. We determined orthostatic heart rate responses in 18 cosmonauts before and 3-5 days after long-term space missions. Cosmonauts undergoing a cardiovascular training program in space experienced only moderate POTS after their return to earth. Cardiovascular countermeasures may have attenuated POTS. Another possible interpretation is that cardiovascular deconditioning is not sufficient to elicit full blown POTS in the absence of additional genetic or environmental factors.
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In 18 cosmonauts who had spent several months on a space station, previously healthy individuals experienced moderate hemodynamic changes that almost meet some POTS criteria (average orthostatic heart rate increase by 26 bpm in absence of orthostatic hypotension), with one individual meeting the orthostatic tachycardia criterion (heart rate increase by 31 bpm), despite regular cardiovascular exer
“Another study in 18 cosmonauts, who had spent several months on a space station, demonstrated that previously healthy individuals can experience moderate hemodynamic changes that almost meet some POTS criteria (average orthostatic heart rate increase by 26 bpm in the absence of orthostatic hypotension), with one individual meeting the orthostatic tachycardia criterion (heart rate increase by 31 b”
From Postural orthostatic tachycardia syndrome: mechanisms and new therapies (2020) · cites this paper as [40]
In POTS, the physiological reactions to orthostatic stress are similar to those seen in deconditioning from prolonged bed rest or space flight, including tachycardia, exercise intolerance, and lower left ventricular mass, stroke volume, and blood volume.
“The physiological responses to orthostatic stress in POTS often resemble the clinical phenotype of patients with deconditioning from prolonged bed rest or space flight (e.g.tachycardia, exercise intolerance, and reductions in left ventricular mass, stroke volume, blood volume) (Fu et al., 2010a;Levine et al., 1997;Tank et al., 2011).”
From Postural tachycardia syndrome – Diagnosis, physiology, and prognosis (2018) · cites this paper as Tank et al., 2011
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- Authors
- Tank, J., Baevsky, R. M., Funtova, I. I., Diedrich, A., Slepchenkova, I. N., & Jordan, J.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Institute of Biomedical Problems (RU)
- Vanderbilt University (US)
- Corresponding author
- Tank, Jens
- Venue
- Clinical Autonomic Research
- Published
- 2010-12-25
- Volume
- 21
- Issue
- 2
- Pages
- 121-124
- ISSN
- 0959-9851 (ISSN-L)
- 1619-1560
- OpenAlex
- W1975129549
- Cited by
- 32
- References
- 14
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 2 · 2016: 3 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Clinical Autonomic Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsches Zentrum für Luft- und Raumfahrt
- National Heart, Lung, and Blood Institute (P01HL056693)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- orthostatic tachycardia, postural orthostatic tachycardia syndrome, cosmonauts, cardiovascular deconditioning, autonomic dysfunction
- MeSH terms
- Adult, Heart Rate, Humans, Male, Space Flight, Weightlessness, Exercise, Cardiovascular Deconditioning, Postural Orthostatic Tachycardia Syndrome
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