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Cited by 177Microbial Metabolic Engineering and BioproductionMicrobial bioremediation and biosurfactantsMicrobial Fuel Cells and Bioremediation

Synthetic microbial consortia for biosynthesis and biodegradation: promises and challenges

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Che, Shun, Men, Yujie·2019·Journal of Industrial Microbiology and Biotechnology
DOI 10.1007/s10295-019-02211-4
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Abstract

Functional differentiation and metabolite exchange enable microbial consortia to perform complex metabolic tasks and efficiently cycle the nutrients. Inspired by the cooperative relationships in environmental microbial consortia, synthetic microbial consortia have great promise for studying the microbial interactions in nature and more importantly for various engineering applications. However, challenges coexist with promises, and the potential of consortium-based technologies is far from being fully harnessed. Thorough understanding of the underlying molecular mechanisms of microbial interactions is greatly needed for the rational design and optimization of defined consortia. These knowledge gaps could be potentially filled with the assistance of the ongoing revolution in systems biology and synthetic biology tools. As current fundamental and technical obstacles down the road being removed, we would expect new avenues with synthetic microbial consortia playing important roles in biological and environmental engineering processes such as bioproduction of desired chemicals and fuels, as well as biodegradation of persistent contaminants.

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  • The application of synthetic biology in bioremediation raises ecological and ethical concerns related to genetic stability, horizontal gene transfer, and unintended environmental impacts.

    “In addition, the application of synthetic biology in bioremediation raises ecological and ethical concerns related to genetic stability, horizontal gene transfer, and unintended environmental impacts [63].”

    From Harnessing bacterial consortia for effective bioremediation: targeted removal of heavy metals, hydrocarbons, and persistent pollutants (2025) · cites this paper as [63]

    The biodegradation/bioremediation section says engineered microbial consortia are largely restricted to well-controlled processes to avoid genetic contamination from environmental microorganisms. This supports a concern about genetic contamination, but our copy does not identify horizontal gene transfer, genetic instability, ethical concerns, or unintended environmental impacts as risks of their use. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Che, S., & Men, Y.
Affiliations
University of Illinois Urbana-Champaign (US)
Corresponding author
Men, Yujie
ORCID
Venue
Journal of Industrial Microbiology and Biotechnology
Publisher
Oxford University Press (OUP)
Published
2019-10-01
Volume
46
Issue
9-10
Pages
1343-1358
ISSN
  • 1367-5435 (ISSN-L)
  • 1476-5535
DOI
10.1007/s10295-019-02211-4
OpenAlex
W2954536068
Cited by
177
References
3
Citations by year
2026: 40 · 2025: 32 · 2024: 21 · 2023: 28 · 2022: 30 · 2021: 15 · 2020: 10 · 2018: 1
FWCI
1.23
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Industrial Microbiology & Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
  • Physical Sciences › Environmental Science › Pollution › Microbial bioremediation and biosurfactants
  • Physical Sciences › Environmental Science › Environmental Engineering › Microbial Fuel Cells and Bioremediation
Keywords
synthetic microbial consortia, microbial interactions, metabolite exchange, functional differentiation, biodegradation, bioproduction, persistent contaminants, systems biology, synthetic biology
MeSH terms
Animals, Biodegradation, Environmental, Humans, Systems Biology, Microbial Interactions, Synthetic Biology, Microbial Consortia

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