Efficacy of Probiotics in Irritable Bowel Syndrome: A Meta-Analysis of Randomized, Controlled Trials
Abstract
PURPOSE: This study was designed to evaluate whether probiotics improve symptoms in patients with irritable bowel syndrome. METHODS: PubMed, Embase, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials were searched for studies that investigated the efficacy of probiotics in the management of irritable bowel syndrome. Clinical improvement was the key outcome of interest. Data were searched within the time period of 1966 through September 2007. RESULTS: Eight randomized, placebo-controlled, clinical trials met our criteria and were included in the analysis. Pooling of eight trials for the outcome of clinical improvement yielded a significant relative risk of 1.22 (95 percent confidence interval, 1.07-1.4; P = 0.0042). CONCLUSIONS: Probiotics may improve symptoms of irritable bowel syndrome and can be used as supplement to standard therapy.
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Probiotics are beneficial in improving overall symptoms in patients with IBS, but there are contradictory reports on improvements in specific symptoms.
“Based on the international consensus and existing evidence, probiotics are beneficial in improving overall symptoms in patients with IBS [29,30,31,32,33,34,35], but there are still contradictory reports on improvements in specific symptoms [36,37,38].”
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Self-citation
- Authors
- Nikfar, S., Rahimi, R., Rahimi, F., Derakhshani, S., & Abdollahi, M.
- Affiliations
- Ministry of Health and Medical Education (IR)
- Pharmaceutical Sciences Research Center (IR)
- Venue
- Diseases of the Colon & Rectum
- Published
- 2008-12
- Volume
- 51
- Issue
- 12
- Pages
- 1775-1780
- ISSN
- 0012-3706 (ISSN-L)
- OpenAlex
- W2110951839
- Cited by
- 155
- References
- 5
- Citations by year
- 2024: 1 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 8 · 2018: 2 · 2017: 8 · 2016: 6 · 2015: 6 · 2014: 14 · 2013: 15 · 2012: 23
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diseases of the Colon & Rectum (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, irritable bowel syndrome, symptom improvement, clinical improvement, dietary supplements, treatment efficacy
- MeSH terms
- Humans, Randomized Controlled Trials as Topic, Treatment Outcome, Probiotics, Irritable Bowel Syndrome
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