Gut microbiota and gastrointestinal health: current concepts and future directions

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works

Enterotypes of the human gut microbiome

MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works

Linking long-term dietary patterns with gut microbial enterotypes

Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works

The gut microbiota as an environmental factor that regulates fat storage

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579 · see citing works

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030 · see citing works

The gut microbiota shapes intestinal immune responses during health and disease

Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029 · see citing works

Host-gut microbiota metabolic interactions

Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760 · see citing works

Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611 · see citing works

<i>Faecalibacterium prausnitzii</i> is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works

Gut microbiota in health and disease

Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works

Ingestion of <i>Lactobacillus</i> strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works

Gut microbiota composition correlates with diet and health in the elderly

Claesson, M. J., Jeffery, I. B., Conde, S., Power, S. E., O’Connor, E. M., Cusack, S., Harris, H. M. B., Coakley, M., Lakshminarayanan, B., O’Sullivan, O., et al. (2012) · Nature · doi:10.1038/nature11319 · Cited by 3,314 · see citing works

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice

Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X., Kubo, C., & Koga, Y. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063388 · Cited by 2,735 · see citing works

Human nutrition, the gut microbiome and the immune system

Kau, A. L., Ahern, P. P., Griffin, N. W., Goodman, A. L., & Gordon, J. I. (2011) · Nature · doi:10.1038/nature10213 · Cited by 2,588 · see citing works

Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach

Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277 · see citing works

Microbial Influences in Inflammatory Bowel Diseases

Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927 · see citing works

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

Claesson, M. J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E., Marchesi, J. R., Falush, D., Dinan, T., Fitzgerald, G., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000097107 · Cited by 1,754 · see citing works

Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut

Suau, A., Bonnet, R., Sutren, M., Godon, J.-J., Gibson, G. R., Collins, M. D., & Doré, J. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.11.4799-4807.1999 · Cited by 1,490 · see citing works

Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles

O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448 · see citing works

Reduced anxiety-like behavior and central neurochemical change in germ-free mice: Behavior in germ-free mice

Neufeld, K. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Neurogastroenterology &amp; Motility · doi:10.1111/j.1365-2982.2010.01620.x · Cited by 1,392 · see citing works

Developmental microbial ecology of the neonatal gastrointestinal tract

Mackie, R. I., Sghir, A., & Gaskins, H. R. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.5.1035s · Cited by 1,360 · see citing works

Temperature Gradient Gel Electrophoresis Analysis of 16S rRNA from Human Fecal Samples Reveals Stable and Host-Specific Communities of Active Bacteria

Zoetendal, E. G., Akkermans, A. D. L., & de Vos, W. M. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3854-3859.1998 · Cited by 1,360 · see citing works

Principles and clinical implications of the brain-gut-enteric microbiota axis

Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · see citing works

The fundamental basis of inflammatory bowel disease

Strober, W., Fuss, I. J., & Mannon, P. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30587 · Cited by 1,310 · see citing works

Diet, gut microbiota and immune responses

Maslowski, K. M., & Mackay, C. R. (2011) · Nature Immunology · doi:10.1038/ni0111-5 · Cited by 1,261 · see citing works

Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss

Furet, J.-P., Kong, L.-C., Tap, J., Poitou, C., Basdevant, A., Bouillot, J.-L., Mariat, D., Corthier, G., Doré, J., Henegar, C., et al. (2010) · Diabetes · doi:10.2337/db10-0253 · Cited by 1,173 · see citing works

Global and Deep Molecular Analysis of Microbiota Signatures in Fecal Samples From Patients With Irritable Bowel Syndrome

Rajilić–Stojanović, M., Biagi, E., Heilig, H. G. H. J., Kajander, K., Kekkonen, R. A., Tims, S., & de Vos, W. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.043 · Cited by 1,041 · see citing works

Rifaximin Therapy for Patients with Irritable Bowel Syndrome without Constipation

Pimentel, M., Lembo, A., Chey, W. D., Zakko, S., Ringel, Y., Yu, J., Mareya, S. M., Shaw, A. L., Bortey, E., & Forbes, W. P. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1004409 · Cited by 1,036 · see citing works

The microbiome-gut-brain axis: from bowel to behavior

Cryan, J. F., & O’Mahony, S. M. (2011) · Neurogastroenterology &amp; Motility · doi:10.1111/j.1365-2982.2010.01664.x · Cited by 990 · see citing works

Brain-gut-microbe communication in health and disease

Grenham, S., Clarke, G., Cryan, J. F., & Dinan, T. G. (2011) · Frontiers in Physiology · doi:10.3389/fphys.2011.00094 · Cited by 952 · see citing works

Intestinal microbiota in functional bowel disorders: a Rome foundation report

Simrén, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J., & Zoetendal, E. G. (2013) · Gut · doi:10.1136/gutjnl-2012-302167 · Cited by 939 · see citing works

Towards the human intestinal microbiota phylogenetic core

Tap, J., Mondot, S., Levenez, F., Pelletier, E., Caron, C., Furet, J., Ugarte, E., Muñoz‐Tamayo, R., Paslier, D. L. E., Nalin, R., et al. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01982.x · Cited by 927 · see citing works

An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota

Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835 · see citing works

Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors

Rousseaux, C., Thuru, X., Gelot, A., Barnich, N., Neut, C., Dubuquoy, L., Dubuquoy, C., Merour, E., Geboes, K., Chamaillard, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1521 · Cited by 793 · see citing works

Targeting gut microbiota in obesity: effects of prebiotics and probiotics

Delzenne, N. M., Neyrinck, A. M., Bäckhed, F., & Cani, P. D. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.126 · Cited by 783 · see citing works

Obesity and the human microbiome

Ley, R. E. (2009) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328333d751 · Cited by 760 · see citing works

Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon

Seksik, P., Rigottier‐Gois, L., Gramet, G., BRIEND‐SUTREN, M., Pochart, P., Marteau, P. R., Jian, R., & Dore, J. M. (2003) · Gut · doi:10.1136/gut.52.2.237 · Cited by 746 · see citing works

The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review

Moayyedi, P., Ford, A. C., Talley, N. J., Cremonini, F., Foxx-Orenstein, A. E., Brandt, L. J., & Quigley, E. M. M. (2010) · Gut · doi:10.1136/gut.2008.167270 · Cited by 728 · see citing works

Immune Activation in Patients With Irritable Bowel Syndrome

Liebregts, T., Adam, B., Bredack, C., Röth, A., Heinzel, S., Lester, S., Downie–Doyle, S., Smith, E., Drew, P., Talley, N. J., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.046 · Cited by 660 · see citing works

Hypothalamic-Pituitary-Gut Axis Dysregulation in Irritable Bowel Syndrome: Plasma Cytokines as a Potential Biomarker?

Dinan, T. G., Quigley, E. M. M., Ahmed, S. M. M., Scully, P., O’Brien, S., O’Mahony, L., O’Mahony, S., Shanahan, F., & Keeling, P. W. N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.033 · Cited by 636 · see citing works

The Relationship Between Intestinal Microbiota and the Central Nervous System in Normal Gastrointestinal Function and Disease

Collins, S. M., & Bercik, P. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.01.075 · Cited by 612 · see citing works

Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn’s disease and ulcerative colitis

Franchimont, D. P., Vermeire, S., Housni, H. E., Pierik, M. J., Steen, K. V., Gustot, T., Quertinmont, E., Abramowicz, M., Gossum, A. V., Devière, J., et al. (2004) · Gut · doi:10.1136/gut.2003.030205 · Cited by 596 · see citing works

Beneficial psychological effects of a probiotic formulation ( <i>Lactobacillus helveticus</i> R0052 and <i>Bifidobacterium longum</i> R0175) in healthy human volunteers

Messaoudi, M., Violle, N., Bisson, J.-F., Desor, D., Javelot, H., & Rougeot, C. (2011) · Gut Microbes · doi:10.4161/gmic.2.4.16108 · Cited by 574 · see citing works

Clinical trial: The effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome

SILK, D. B. A., DAVIS, A., VULEVIC, J., TZORTZIS, G., & GIBSON, G. R. (2009) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/j.1365-2036.2008.03911.x · Cited by 551 · see citing works

Mode and place of delivery, gastrointestinal microbiota, and their influence on asthma and atopy

van Nimwegen, F. A., Penders, J., Stobberingh, E. E., Postma, D. S., Koppelman, G. H., Kerkhof, M., Reijmerink, N. E., Dompeling, E., van den Brandt, P. A., Ferreira, I., et al. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.07.027 · Cited by 493 · see citing works

Antibiotic use and inflammatory bowel diseases in childhood

Hviid, A. P., Svanström, H., & Frisch, M. (2010) · Gut · doi:10.1136/gut.2010.219683 · Cited by 492 · see citing works

The role of the gut microbiota in nonalcoholic fatty liver disease

Abu-Shanab, A., & Quigley, E. M. M. (2010) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2010.172 · Cited by 457 · see citing works

The role of the intestinal microbiota in the development of atopic disorders

Penders, J., Stobberingh, E. E., van den Brandt, P. A., & Thijs, C. T. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01462.x · Cited by 435 · see citing works

Imbalance in the composition of the duodenal microbiota of children with coeliac disease

Nadal, I., Donant, E., Ribes‐Koninckx, C., Calabuig, M., & Sanz, Y. (2007) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47410-0 · Cited by 396 · see citing works

Techniques used to characterize the gut microbiota: a guide for the clinician

Fraher, M. H., O'Toole, P. W., & Quigley, E. M. M. (2012) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2012.44 · Cited by 385 · see citing works

Functional dysbiosis within the gut microbiota of patients with constipated‐irritable bowel syndrome

Chassard, C., Dapoigny, M. C., Scott, K. P., Crouzet, L., Del’Homme, C., Marquet, P., Martin, J. C., Pickering, G. P., Ardid, D., Eschalier, A., et al. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05007.x · Cited by 366 · see citing works

The Utility of Probiotics in the Treatment of Irritable Bowel Syndrome: A Systematic Review

Brenner, D. M., Moeller, M. J., Chey, W. D., & Schoenfeld, P. S. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.25 · Cited by 362 · see citing works

The Relationship Between Gut Microbiota and Weight Gain in Humans

Angelakis, E., Armougom, F., Million, M., & Raoult, D. (2011) · Future Microbiology · doi:10.2217/fmb.11.142 · Cited by 357 · see citing works

The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus

Kootte, R. S., Vrieze, A., Holleman, F., Dallinga‐Thie, G. M., Zoetendal, E. G., de Vos, W. M., Groen, A. K., Hoekstra, J. B. L., Stroes, E. S. G., & Nieuwdorp, M. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01483.x · Cited by 348 · see citing works

Meta-analysis of probiotics for the treatment of irritable bowel syndrome

McFarland, L. V., & Dublin, S. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.2650 · Cited by 341 · see citing works

Antibiotic-Associated Diarrhea: Epidemiology, Trends and Treatment

McFarland, L. V. (2008) · Future Microbiology · doi:10.2217/17460913.3.5.563 · Cited by 336 · see citing works

Resilience of the Dominant Human Fecal Microbiota upon Short-Course Antibiotic Challenge

Cochetiere, M. F. D. L., Durand, T., Lepage, P., Bourreille, A., Galmiche, J. P., & Dore, J. M. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.11.5588-5592.2005 · Cited by 333 · see citing works

A Systematic Review of Diagnostic Tests for Small Intestinal Bacterial Overgrowth

Khoshini, R., Dai, S.-C., Lezcano, S., & Pimentel, M. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-0065-1 · Cited by 323 · see citing works

Mechanisms of Disease: the hygiene hypothesis revisited

Guarner, F., Bourdet‐Sicard, R., Brandtzæg, P., Gill, H. S., McGuirk, P., van Eden, W., Versalovic, J. A., Weinstock, J. V., & Rook, G. A. W. (2006) · Nature Clinical Practice Gastroenterology &#38 Hepatology · doi:10.1038/ncpgasthep0471 · Cited by 315 · see citing works

Effects of the gut microbiota on obesity and glucose homeostasis

Greiner, T. U., & Bäckhed, F. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.01.002 · Cited by 304 · see citing works

A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome

Hoveyda, N., Heneghan, C., Mahtani, K. R., Perera, R., Roberts, N., & Glasziou, P. (2009) · BMC Gastroenterology · doi:10.1186/1471-230x-9-15 · Cited by 297 · see citing works

Bifidobacterium infantis 35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells

Konieczna, P., Groeger, D., Ziegler, M., Frei, R., Ferstl, R., Shanahan, F., Quigley, E. M. M., Kiely, B., Akdiş, C. A., & O’Mahony, L. (2011) · Gut · doi:10.1136/gutjnl-2011-300936 · Cited by 284 · see citing works

Top-Down Systems Biology Modeling of Host Metabotype−Microbiome Associations in Obese Rodents

Waldram, A., Holmes, E. C., Wang, Y., Rantalainen, M., Wilson, I. D., Tuohy, K. M., McCartney, A. L., Gibson, G. R., & Nicholson, J. K. (2009) · Journal of Proteome Research · doi:10.1021/pr8009885 · Cited by 266 · see citing works

Regulation of Homeostasis and Inflammation in the Intestine

MacDonald, T. T., Monteleone, I., Fantini, M. C., & Monteleone, G. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.047 · Cited by 262 · see citing works

Programming of Host Metabolism by the Gut Microbiota

Bäckhed, F. (2011) · Annals of Nutrition and Metabolism · doi:10.1159/000328042 · Cited by 256 · see citing works

Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism

Caesar, R., Fåk, F., & Bäckhed, F. (2010) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2010.02270.x · Cited by 253 · see citing works

Prebiotics and probiotics; modifying and mining the microbiota

Quigley, E. M. M. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.01.004 · Cited by 238 · see citing works

Temporal stability analysis of the microbiota in human feces by denaturing gradient gel electrophoresis using universal and group-specific 16S rRNA gene primers

Vanhoutte, T., Huys, G. R. B., Brandt, E. D., & Swings, J. (2004) · FEMS Microbiology Ecology · doi:10.1016/j.femsec.2004.03.001 · Cited by 215 · see citing works

Irritable Bowel Syndrome

Mertz, H. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmra035579 · Cited by 206 · see citing works

Differential Expression of Toll-Like Receptors in Patients With Irritable Bowel Syndrome

Brint, E. K., MacSharry, J., Fanning, A., Shanahan, F., & Quigley, E. M. M. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.438 · Cited by 205 · see citing works

Meta-analysis: Lactobacillus rhamnosus GG for abdominal pain-related functional gastrointestinal disorders in childhood: Meta-analysis: Lactobacillus GG and abdominal pain-related functional disorders

Horvath, A., Dziechciarz, P., & Szajewska, H. (2011) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/j.1365-2036.2011.04665.x · Cited by 201 · see citing works

Elevated Human β-Defensin-2 Levels Indicate an Activation of the Innate Immune System in Patients With Irritable Bowel Syndrome

Langhorst, J., Junge, A., Rueffer, A., Wehkamp, J., Foell, D., Michalsen, A., Musial, F., & Dobos, G. J. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.86 · Cited by 167 · see citing works

Review article: the role of bacteria in onset and perpetuation of inflammatory bowel disease

Seksik, P., Sokol, H., Lepage, P., Vasquez, N., Manichanh, C., Mangin, I., Pochart, P., Dore, J. M., & Marteau, P. R. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03053.x · Cited by 166 · see citing works

Efficacy of Probiotics in Irritable Bowel Syndrome: A Meta-Analysis of Randomized, Controlled Trials

Nikfar, S., Rahimi, R., Rahimi, F., Derakhshani, S., & Abdollahi, M. (2008) · Diseases of the Colon &amp; Rectum · doi:10.1007/s10350-008-9335-z · Cited by 155 · see citing works

Lactobacillus casei downregulates commensalsʼ inflammatory signals in Crohnʼs disease mucosa

Llopis, M., Antolı́n, M., Carol, M., Borruel, N., Casellas, F., Martínez, C., Espín, E., Guarner, F., & Malagelada, J. R. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20736 · Cited by 145 · see citing works

The Gut Microbiota and Irritable Bowel Syndrome: Friend or Foe?

Ghoshal, U. C., Shukla, R., Ghoshal, U., Gwee, K., Ng, S. C., & Quigley, E. M. M. (2012) · International Journal of Inflammation · doi:10.1155/2012/151085 · Cited by 143 · see citing works

The Role of the Gastrointestinal Microbiota in Colorectal Cancer

Rowland, I. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168191 · Cited by 129 · see citing works

Gut microbiota, epithelial function and derangements in obesity

Raybould, H. E. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.222133 · Cited by 110 · see citing works

Small Intestinal Bacterial Overgrowth

Quigley, E. M. M., & Abu-Shanab, A. (2010) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2010.07.007 · Cited by 108 · see citing works

Gut microbiota and the role of probiotics in therapy

Quigley, E. M. M. (2011) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2011.09.010 · Cited by 88 · see citing works

The enteric microbiota in the pathogenesis and management of constipation

Quigley, E. M. M. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.01.003 · Cited by 86 · see citing works

The small intestinal bacterial overgrowth. Irritable bowel syndrome hypothesis: implications for treatment

Vanner, S. (2008) · Gut · doi:10.1136/gut.2007.133629 · Cited by 78 · see citing works

Role of probiotics in correcting abnormalities of colonic flora induced by stress: Figure 1

Eutamène, H., & Bueno, L. P. (2007) · Gut · doi:10.1136/gut.2007.124040 · Cited by 72 · see citing works

Therapies Aimed at the Gut Microbiota and Inflammation: Antibiotics, Prebiotics, Probiotics, Synbiotics, Anti-inflammatory Therapies

Quigley, E. M. M. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.12.009 · Cited by 67 · see citing works

Colloquium Series on Integrated Systems Physiology: From Molecule to Function to Disease

Granger, D. N., & Granger, J. P. (2011) · Cited by 60 · see citing works

Clinical utility of probiotics in inflammatory bowel disease.

Cain, A. M., & Karpa, K. D. (2011) · PubMed · Cited by 49 · see citing works

Molecular comparison of dominant microbiota associated with injured versus healthy mucosa in ulcerative colitis

Sokol, H., Lepage, P., Seksik, P., et al. (2006) · Gut · doi:10.1136/gut.2006.109686 · Cited by 45 · see citing works

Life in the Gut: Microbial responses to Stress in the Gastrointestinal Tract

Louis, P., & O'Byrne, C. P. (2010) · Science Progress · doi:10.3184/003685009x12605525292307 · Cited by 40 · see citing works

Probiotics, prebiotics, synbiotics: ecological treatment for inflammatory bowel disease?

Marteau, P. R. (2006) · Gut · doi:10.1136/gut.2004.051458 · Cited by 38 · see citing works

Pathogenic Factors Involved in the Development of Irritable Bowel Syndrome: Focus on a Microbial Role

Bolino, C., & Berčík, P. (2010) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2010.07.005 · Cited by 34 · see citing works

Targeting the microbiota–gut–brain axis to modulate behavior: Which bacterial strain will translate best to humans?

McLean, P. G., Bergonzelli, G. E., Collins, S. M., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118626109 · Cited by 30 · see citing works

The Pathogenesis of Bloating and Visible Distension in Irritable Bowel Syndrome

Azpiroz, F., & Malagelada, J. R. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.02.006 · Cited by 21 · see citing works

The Enteric Microbiota

Guarner, F. (2011) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00047ed1v01y201110isp029 · Cited by 4 · see citing works

Microbiota and neurodevelopmental windows: implications for brain disorders

Borre, Y. E., O’Keeffe, G. W., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.05.002 · Cited by 1,089 · see citing works

From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

Rogers, G. B., Keating, D. J., Young, R. L., Wong, M.-L., Licinio, J., & Wesselingh, S. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.50 · Cited by 969 · see citing works

Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial

Akbari, E., Asemi, Z., Daneshvar Kakhaki, R., Bahmani, F., Kouchaki, E., Tamtaji, O. R., Hamidi, G. A., & Salami, M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00256 · Cited by 946 · see citing works

Benefaction of probiotics for human health: A review

George Kerry, R., Patra, J. K., Gouda, S., Park, Y., Shin, H.-S., & Das, G. (2018) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2018.01.002 · Cited by 898 · see citing works

The composition and stability of the vaginal microbiota of normal pregnant women is different from that of non-pregnant women

Romero, R., Hassan, S. S., Gajer, P., Tarca, A. L., Fadrosh, D. W., Nikita, L., Galuppi, M., Lamont, R. F., Chaemsaithong, P., Miranda, J., et al. (2014) · Microbiome · doi:10.1186/2049-2618-2-4 · Cited by 852 · see citing works

Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity

Bruce-Keller, A. J., Salbaum, J. M., Luo, M., Blanchard, E., Taylor, C. M., Welsh, D. A., & Berthoud, H.-R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.012 · Cited by 563 · see citing works

Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

Pistollato, F., Sumalla Cano, S., Elio, I., Masias Vergara, M., Giampieri, F., & Battino, M. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw023 · Cited by 496 · see citing works

Alzheimer’s disease and gut microbiota

Hu, X., Wang, T., & Jin, F. (2016) · Science China Life Sciences · doi:10.1007/s11427-016-5083-9 · Cited by 371 · see citing works

Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

Więckowska-Gacek, A., Mietelska-Porowska, A., Wydrych, M., & Wojda, U. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101397 · Cited by 343 · see citing works

The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?

Megur, A., Baltriukienė, D., Bukelskienė, V., & Burokas, A. (2020) · Nutrients · doi:10.3390/nu13010037 · Cited by 323 · see citing works

Microbiota regulation of the mammalian gut-brain axis

Burokas, A., Moloney, R. D., Dinan, T. G., & Cryan, J. F. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.02.001 · Cited by 300 · see citing works

Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms

Felice, V. D., Quigley, E. M., Sullivan, A. M., O'Keeffe, G. W., & O'Mahony, S. M. (2016) · Parkinsonism &amp; Related Disorders · doi:10.1016/j.parkreldis.2016.03.012 · Cited by 205 · see citing works

Gut Microbiota: The Brain Peacekeeper

Mu, C., Yang, Y., & Zhu, W. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00345 · Cited by 188 · see citing works

Altered faecal and mucosal microbial composition in post‐infectious irritable bowel syndrome patients correlates with mucosal lymphocyte phenotypes and psychological distress

Sundin, J., Rangel, I., Fuentes, S., Heikamp‐de Jong, I., Hultgren‐Hörnquist, E., de Vos, W. M., & Brummer, R. J. (2015) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/apt.13055 · Cited by 164 · see citing works

Fundamentals of Neurogastroenterology: Physiology/Motility – Sensation

Boeckxstaens, G., Camilleri, M., Sifrim, D., Houghton, L. A., Elsenbruch, S., Lindberg, G., Azpiroz, F., & Parkman, H. P. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.030 · Cited by 142 · see citing works

Colonic Transit Time Is a Driven Force of the Gut Microbiota Composition and Metabolism: In Vitro Evidence

Tottey, W., Feria-Gervasio, D., Gaci, N., Laillet, B., Pujos, E., Martin, J.-F., Sebedio, J.-L., Sion, B., Jarrige, J.-F., Alric, M., et al. (2017) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16042 · Cited by 125 · see citing works

Maternal obese-type gut microbiota differentially impact cognition, anxiety and compulsive behavior in male and female offspring in mice

Bruce-Keller, A. J., Fernandez-Kim, S.-O., Townsend, R. L., Kruger, C., Carmouche, R., Newman, S., Salbaum, J. M., & Berthoud, H.-R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175577 · Cited by 76 · see citing works

Interplay of good bacteria and central nervous system: cognitive aspects and mechanistic considerations

Salami, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.613120 · Cited by 67 · see citing works

Gut hormones in microbiota-gut-brain cross-talk

Sun, L.-J., Li, J.-N., & Nie, Y.-Z. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000706 · Cited by 145 · see citing works

The potential of human milk oligosaccharides to impact the microbiota-gut-brain axis through modulation of the gut microbiota

Al-Khafaji, A. H., Jepsen, S. D., Christensen, K. R., & Vigsnæs, L. K. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104176 · Cited by 59 · see citing works

The role of gut microbiota in the gut-brain axis: current challenges and perspectives

Chen, X., D’Souza, R., & Hong, S. (2013) · Protein & Cell · doi:10.1007/s13238-013-3017-x · Cited by 153 · see citing works

The Role of the Gut Microbiota in the Gut–Brain Axis in Obesity: Mechanisms and Future Implications

van Son, J., Koekkoek, L. L., la Fleur, S. E., Serlie, M. J. M., & Nieuwdorp, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062993 · Cited by 82 · see citing works

Role of gut microbiota via the gut-liver-brain axis in digestive diseases

Ding, J., Jin, Z., Yang, X., Lou, J., Shan, W., Hu, Y., Du, Q., Liao, Q., Xie, R., & Xu, J. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i40.6141 · Cited by 172 · see citing works