A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6‐month intervention
Open accessAbstract
Summary: Background : Irritable bowel syndrome is a gastrointestinal disorder of unknown aetiology. The effect of probiotics in this syndrome remains unclear. Aim : To investigate whether a probiotic mixture containing Lactobacillus rhamnosus GG, L. rhamnosus LC705, Bifidobacterium breve Bb99 and Propionibacterium freudenreichii ssp. shermanii JS is effective in alleviating irritable bowel syndrome symptoms. Methods : A total of 103 patients fulfilling the Rome I or II criteria took part in this 6‐month, randomized, double‐blind placebo‐controlled trial. The patients received a probiotic capsule or a placebo capsule daily. Gastrointestinal symptoms and bowel habits were recorded. Results : At the end the total symptom score (abdominal pain + distension + flatulence + borborygmi) was 7.7 (95% CI: −13.9 to −1.6) points lower in the probiotic group (P = 0.015). This represents a median reduction of 42% in the symptom score of the probiotic group compared with 6% in the placebo group. In individual symptoms, borborygmi was milder in the probiotic group (P = 0.008), and for the rest of the symptoms there was a non‐significant trend. Conclusions : The results indicate that this probiotic mixture is effective in alleviating irritable bowel syndrome symptoms. Considering the high prevalence of irritable bowel syndrome and the lack of effective therapies, even a slight reduction in symptoms could have positive public health consequences.
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Most randomized controlled trials of multistrain probiotics in IBS provided daily doses in the range of 5-9 × 10^9 cfu, and in most cases reductions in symptom severity score were observed; some but not all products significantly reduced abdominal pain symptoms.
“Most of the products provided daily doses in the range of 5-9 • 10 9 cfu and, in most cases, reductions in symptom severity score were observed [17][18][19][20][21] and some, but not all, of the products significantly reduced abdominal pain symptoms.”
From Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study (2009) · cites this paper as [19]
The authors' earlier clinical trial found that a multispecies probiotic significantly alleviates IBS symptoms, but the mechanisms behind these effects remain unknown.
“We have recently shown in a clinical trial that a multispecies probiotic significantly alleviates IBS symptoms, but the mechanisms behind the effects are not known. 10”
From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [10]
Two different multispecies probiotic combinations have shown favourable effects on IBS symptoms: one containing two lactobacilli, one bifidobacteria and one propionic acid bacteria, and another containing eight strains (VSL#3).
“Furthermore, two different multispecies probiotics have shown favourable effects on symptoms of IBS: a combination of two lactobacilli, one bifidobacteria and one propionic acid bacteria, 10 as well as a combination of eight strains, VSL#3. 11, 12”
From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [10]
This trial's results agree with earlier work on a comparable multispecies probiotic.
“The results of this study are consistent with our previous findings concerning a similar multispecies probiotic. 10”
From Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota (2008) · cites this paper as [10]
The two B. breve strains included in Table 2 were tested together with other bacteria or with prebiotics such as galacto-oligosaccharides.
“the two strains of B. breve included in the table were tested together with some of these bacteria [139,141] , or even with prebiotics such as galacto-oligosaccharides [140]”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [139]
Specific probiotics help relieve overall symptom burden in some patients with IBS, with high grade of evidence.
“Specific probiotics help relieve overall symptom burden in some patients with IBS High [147,149,150,152,156-157,169, 174,176-178]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [150]
Specific probiotics help reduce bloating/distension in some patients with IBS, with moderate grade of evidence.
“Specific probiotics help reduce bloating/distension in some patients with IBS Moderate [147,149-150,155-156,168-170, 174-177,179-183]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [150]
Probiotics tested to date do not help reduce flatus in patients with IBS, with low grade of evidence.
“Probiotics tested to date do not help reduce flatus in patients with IBS Low [147,149-150,156,168,174-175, 178-179,184]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [150]
With specific probiotics, improvement of symptoms has been shown to lead to improvement in some aspects of health-related quality of life, with moderate grade of evidence.
“With specific probiotics, improvement of symptoms has been shown to lead to improvement in some aspects of health-related quality of life Moderate [147,150,152,155,169-170,174,176-177,179-180,183-184,186]”
From Gut microbiota role in irritable bowel syndrome: New therapeutic strategies (2016) · cites this paper as [150]
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- Authors
- KAJANDER, K., HATAKKA, K., POUSSA, T., FÄRKKILÄ, M., & KORPELA, R.
- Affiliations
- University of Helsinki (FI)
- Valio (Finland) (FI)
- Helsinki University Hospital (FI)
- Corresponding author
- KORPELA, R.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2005-08-26
- Volume
- 22
- Issue
- 5
- Pages
- 387-394
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W2001065399
- Cited by
- 361
- References
- 37
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 7 · 2020: 10 · 2019: 13 · 2018: 15 · 2017: 17 · 2016: 16 · 2015: 15 · 2014: 25 · 2013: 23 · 2012: 30
- FWCI
- 22.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Valio
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- irritable bowel syndrome, probiotics, Lactobacillus rhamnosus GG, abdominal pain, abdominal distension, flatulence, borborygmi, bowel habits, Rome criteria
- MeSH terms
- Adult, Aged, Defecation, Double-Blind Method, Female, Humans, Lactobacillus, Life Style, Male, Medical Records, Middle Aged, Propionibacterium, Quality of Life, Surveys and Questionnaires, Probiotics, Irritable Bowel Syndrome
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