Relationship between psychological distress and health-related quality of life at each point of the treatment of esophageal cancer
Abstract
Background Patients with esophageal cancer often feel depression or fear of death influenced by multiple clinical factors. This study sought to investigate the clinical factors associated with psychological distress, focusing on the influence of health-related quality of life (HRQOL) for better psychological management of patients with esophageal cancer.Methods In total, 102 of 152 consecutive patients surgically treated at Toranomon Hospital met the eligibility criteria for analysis. Questionnaires designed to identify psychological distress and QOL (EORTC QLQ C-30/OES18) were administered at five time points during the treatment course. Degree of psychological distress was assessed by Hospital Anxiety and Depression Scale (HADS).Results Patients with HADS score ≥ 11 at each visit showed significantly higher level of symptoms or problems measured by the score of EORTC QLQ C-30/OES18 compared with those with HADS score ≤ 10. Emotional status was a significant factor associated with psychological distress at all times. Although functional scales including global health status or QOL status and symptom scales associated with esophageal cancer were strongly associated with psychological distress before treatment, scales associated with changes in habitus after esophagectomy showed significant correlation with psychological distress after surgery. No significant correlation was observed between psychological distress and individual baseline characteristics, apart from history of surgery and pathological staging.Conclusions Psychological distress during treatment course of esophageal cancer is significantly associated with HRQOL influenced by esophagectomy. The current results may warrant prospective intervention through enhanced recovery after surgery to better manage patients undergoing highly invasive procedures for esophageal cancer.
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Changes in psychological status of patients undergoing esophagectomy are significantly associated with changes in symptom experience and quality of life brought about by esophagectomy.
“Ohkura et al. longitudinally tracked changes in the psychological status of patients undergoing esophagectomy at fve time points and showed that changes in patients' psychological status were signifcantly associated with changes in symptom experience and quality of life brought about by esophagectomy [47,48].”
From Symptom Experiences before Medical Help-Seeking and Psychosocial Responses of Patients with Esophageal Cancer: A Qualitative Study. (2023) · cites this paper as [47]
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- Authors
- Ohkura, Y., Ichikura, K., Shindoh, J., Ueno, M., Udagawa, H., & Matsushima, E.
- Affiliations
- Tokyo Medical and Dental University (JP)
- Toranomon Hospital (JP)
- Okinaka Memorial Institute for Medical Research (JP)
- Corresponding author
- Ohkura, Yu
- Venue
- Esophagus
- Published
- 2020-01-02
- Volume
- 17
- Issue
- 3
- Pages
- 312-322
- ISSN
- 1612-9059 (ISSN-L)
- 1612-9067
- OpenAlex
- W2998148818
- Cited by
- 29
- References
- 21
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 4
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Esophagus (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Gastric Cancer Management and Outcomes
- Keywords
- esophageal cancer, psychological distress, health-related quality of life, esophagectomy, depression, anxiety, emotional state, Hospital Anxiety and Depression Scale, pathological staging, enhanced recovery after surgery, psychological management
- MeSH terms
- Psychological Distress, Adult, Aged, Aged, 80 and over, Depression, Esophageal Neoplasms, Fear, Female, Health Status, Humans, Japan, Male, Middle Aged, Prospective Studies, Quality of Life, Surveys and Questionnaires, Risk Factors, Esophagectomy
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