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Cited by 107Intestinal and Peritoneal AdhesionsHernia repair and managementSurgical Sutures and Adhesives

Seprafilm® adhesion barrier: (1) a review of preclinical, animal, and human investigational studies

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Diamond, Michael P., Burns, Ellen L., Accomando, Beverly, Mian, Sadiqa, Holmdahl, Lena·2012·Gynecological Surgery
DOI 10.1007/s10397-012-0741-9PMC PMC3401296
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Abstract

The aim of this study was to provide a single site resource for investigators, clinicians, and others seeking preclinical, animal, and human investigational studies concerning the postsurgical, anti-adhesion barrier Seprafilm™ (Genzyme Corporation, Cambridge, MA). All published preclinical, animal, human extra-abdominal research as of July 2011 have been summarized and included in this document. Searches of Medline and EMBASE Drugs and Pharmaceuticals databases were conducted for original preclinical, animal, and human extra-abdominal studies involving Seprafilm. Preclinical, animal, and extra-abdominal human investigational studies are the study selection for this manuscript. Intraabdominal use is discussed in the accompanying manuscript. Data extraction includes systematic manuscript review. Summary of preclinical, animal, and extra-abdominal human investigational use of Seprafilm by surgical discipline were gathered for data synthesis. The clinical use of Seprafilm, which was approved by the FDA for intra-abdominal procedures, is supported by preclinical and animal studies relating to general surgical and obstetrical/gynecological applications. Findings from preclinical, animal, and human investigational studies at other sites throughout the body raises the potential for additional human clinical trials to assess efficacy and safety following surgical procedures at non-abdominal locations.

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  • Seprafilm (hyaluronic acid/carboxymethylcellulose film) is FDA-approved and widely used as a physical barrier to reduce intra-abdominal and pelvic adhesions following surgery.

    “A well-known example of its clinical use is Seprafilm® (hyaluronic acid/carboxymethylcellulose film), which is FDA-approved and widely used as a physical barrier to reduce intra-abdominal and pelvic adhesions following surgery [118].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [118]

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Cited by

Sorted by citations

Authors
Diamond, M. P., Burns, E. L., Accomando, B., Mian, S., & Holmdahl, L.
Affiliations
Wayne State University (US)
Corresponding author
Diamond, Michael P.
ORCID
Diamond, Michael P.
Venue
Gynecological Surgery
Publisher
Springer Science and Business Media LLC
Published
2012-04-20
Volume
9
Issue
3
Pages
237-245
ISSN
  • 1613-2076 (ISSN-L)
  • 1613-2084
DOI
10.1007/s10397-012-0741-9
PMC
PMC3401296
OpenAlex
W2042934127
Cited by
107
References
1
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FWCI
4.98
Type
journal article
Language
en
Open access
Licence
Locations
  • Gynecological Surgery (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
  • Health Sciences › Medicine › Surgery › Hernia repair and management
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
Keywords
Seprafilm, anti-adhesion barrier, postoperative adhesions, obstetrics and gynecology surgery, general surgery, drug safety and efficacy

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