The DOI matches its Crossref record; 245 of the 245 references it cites were found in a registry or an index.
Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps
Open accessAbstract
Parkinson’s disease (PD) is a common neurodegenerative disorder. Neuronal cell death in PD is still poorly understood, despite a wealth of potential pathogenic mechanisms and pathways. Defects in several cellular systems have been implicated as early triggers that start cells down the road toward neuronal death. These include abnormal protein accumulation, particularly of alpha-synuclein; altered protein degradation via multiple pathways; mitochondrial dysfunction; oxidative stress; neuroinflammation; and dysregulated kinase signaling. As dysfunction in these systems mounts, pathways that are more explicitly involved in cell death become recruited. These include JNK signaling, p53 activation, cell cycle re-activation, and signaling through bcl-2 family proteins. Eventually, neurons become overwhelmed and degenerate; however, even the mechanism of final cell death in PD is still unsettled. In this review, we will discuss cell death triggers and effectors that are relevant to PD, highlighting important unresolved issues and implications for the development of neuroprotective therapies.
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Cited by
Pathological roles of MAPK signaling pathways in human diseases
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Oxidative stress in the aging substantia nigra and the etiology of Parkinson's disease
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Rapamycin Protects against Neuron Death in In Vitro and In Vivo Models of Parkinson's Disease
Malagelada, C., Jin, Z. H., Jackson-Lewis, V., Przedborski, S., & Greene, L. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3944-09.2010 · Cited by 462
Self-citationRecent advances in our understanding of neurodegeneration
Jellinger, K. A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0240-y · Cited by 274
Iannielli, A., Bido, S., Folladori, L., Segnali, A., Cancellieri, C., Maresca, A., Massimino, L., Rubio, A., Morabito, G., Caporali, L., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.089 · Cited by 239
Metadata
- Authors
- Levy, O. A., Malagelada, C., & Greene, L. A.
- Venue
- Apoptosis
- Published
- 2009-01-23
- Volume
- 14
- Issue
- 4
- Pages
- 478-500
- ISSN
- 1360-8185 (ISSN-L)
- 1573-675X
- OpenAlex
- W2055874717
- Cited by
- 287
- References
- 245
- FWCI
- 16.50
- Type
- journal article
- Language
- en
- Open access
- green
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