Pathological roles of MAPK signaling pathways in human diseases
Open accessAbstract
The mammalian family of mitogen-activated protein kinases (MAPKs) includes extracellular signal-regulated kinase (ERK), p38, and c-Jun NH(2)-terminal kinase (JNK), with each MAPK signaling pathway consisting of at least three components, a MAPK kinase kinase (MAP3K), a MAPK kinase (MAP2K), and a MAPK. The MAPK pathways are activated by diverse extracellular and intracellular stimuli including peptide growth factors, cytokines, hormones, and various cellular stressors such as oxidative stress and endoplasmic reticulum stress. These signaling pathways regulate a variety of cellular activities including proliferation, differentiation, survival, and death. Deviation from the strict control of MAPK signaling pathways has been implicated in the development of many human diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and various types of cancers. Persistent activation of the JNK or p38 signaling pathways has been suggested to mediate neuronal apoptosis in AD, PD, and ALS, whereas the ERK signaling pathway plays a key role in several steps of tumorigenesis including cancer cell proliferation, migration, and invasion. In this review, we summarize recent findings on the roles of MAPK signaling pathways in human disorders, focusing on cancer and neurodegenerative diseases including AD, PD, and ALS.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
More than 20 serine/threonine kinases are reported to phosphorylate tau in vitro, including GSK-3β, Cdk5, MARK1-4, ERK, p38α MAPK, and JNK.
“In fact, there are currently more than 20 serine/threonine kinases reported to phosphorylate tau in vitro: glycogen synthase kinase 3 beta (GSK-3β), cyclin-dependent kinase 5 (Cdk5), microtubule affinity regulating kinase 1–4 (MARK1–MAPK4), extracellular signal-related kinase (ERK), p38 mitogen-associated protein kinase alpha (p38α MAPK), and c-Jun N-terminal kinase (JNK) are the best examples [19”
From Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology (2016) · cites this paper as [21]
Section 2.1 (Alzheimer’s disease; page not provided) says that JNK, p38, and ERK mediate tau phosphorylation. It does not give a count of more than 20 kinases, specify in-vitro evidence, or identify GSK-3β, Cdk5, MARK1–4, or specifically p38α as tau kinases. (LLM, conf=0.88)
Experimental — accuracy not yet measuredMultilevel proteomic analyses suggest activation of MAP kinase signaling implicated in AD pathogenesis.
“Collectively, these multilevel proteomic analyses suggest the activation of MAP kinase signaling that is implicated in AD pathogenesis (Kim and Choi, 2010).”
From Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression (2020) · cites this paper as Kim and Choi, 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Batelli, S., Albani, D., Rametta, R., Polito, L., Prato, F., Pesaresi, M., Negro, A., & Forloni, G. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001884 · Cited by 130 · see citing works
Retracted<i>EGFR</i> Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Paez, J. G., Jänne, P. A., Lee, J. C., Tracy, S., Greulich, H., Gabriel, S., Herman, P., Kaye, F. J., Lindeman, N., Boggon, T. J., et al. (2004) · Science · doi:10.1126/science.1099314 · Cited by 9,368 · see citing works
Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382 · see citing works
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455 · see citing works
α-Synuclein Locus Triplication Causes Parkinson's Disease
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) · Science · doi:10.1126/science.1090278 · Cited by 4,383 · see citing works
Signal transduction by the JNK group of MAP kinases
Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237 · see citing works
Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation
Gurney, M. E., Pu, H., Chiu, A. Y., Dal Canto, M. C., Polchow, C. Y., Alexander, D. D., Caliendo, J., Hentati, A., Kwon, Y. W., Deng, H.-X., et al. (1994) · Science · doi:10.1126/science.8209258 · Cited by 4,143 · see citing works
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026 · see citing works
Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · cited 1× · see citing works
“Amyloidogenic Aβ is produced by β-secretase-mediated cleavage of APP at amino acid 83, whereas non-amyloidogenic Aβ, which is not toxic to neurons, is generated by α-secretase-mediated APP cleavage at amino acid 99 [24,25].”
BackgroundMutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
Zimprich, A. A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M. J., Lincoln, S., Kachergus, J. M., Hulihan, M., Uitti, R. J., Calne, D. B., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.005 · Cited by 3,024 · see citing works
MAP kinase signalling pathways in cancer
Dhillon, A. S., Hagan, S., Rath, O., & Kolch, W. (2007) · Oncogene · doi:10.1038/sj.onc.1210421 · Cited by 2,995 · see citing works
Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF
Wan, P., Garnett, M. J., Roe, S. M., Lee, S., Niculescu‐Duvaz, D., Good, V. M., Cancer Genome Project, Jones, C. M., Marshall, C. J., Springer, C. J., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00215-6 · Cited by 2,800 · see citing works
Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
Kwiatkowski, T. J., Bosco, D. A., LeClerc, A. L., Tamrazian, E., Vanderburg, C. R., Russ, C., Davis, A., Gilchrist, J. M., Kasarskis, E. J., Munsat, T. L., et al. (2009) · Science · doi:10.1126/science.1166066 · Cited by 2,555 · see citing works
α-synuclein locus duplication as a cause of familial Parkinson's disease
Chartier-Harlin, M.-C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Larvor, L., Andrieux, J., Hulihan, M., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17103-1 · Cited by 2,029 · see citing works
Neuroinflammation in Parkinson’s disease: A target for neuroprotection?
Hirsch, E. C., & Hunot, S. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70062-6 · Cited by 1,984 · see citing works
Intracellular amyloid-β in Alzheimer's disease
LaFerla, F. M., Green, K. N., & Oddo, S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2168 · Cited by 1,942 · see citing works
RAS oncogenes: the first 30 years
Malumbres, M., & Barbacid, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1097 · Cited by 1,902 · see citing works
Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W.-H., Castillo, P. E., Shinsky, N., Verdugo, J. M. G., Armanini, M., Ryan, A., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)80886-7 · Cited by 1,722 · see citing works
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
Park, J., Lee, S. B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.-M., et al. (2006) · Nature · doi:10.1038/nature04788 · Cited by 1,705 · see citing works
Purification and cloning of amyloid precursor protein β-secretase from human brain
Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, M., Dovey, H. F., Frigon, N., Hong, J., et al. (1999) · Nature · doi:10.1038/990114 · Cited by 1,612 · see citing works
Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
Schaeffer, H. J., & Weber, M. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2435 · Cited by 1,600 · cited 3× · see citing works
“[90] L. Resnick, M. Fennell, Targeting JNK3 for the treatment of neurodegenerative disorders, Drug Discov.”
BackgroundHyperactive Ras in developmental disorders and cancer
Schubbert, S., Shannon, K., & Bollag, G. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2109 · Cited by 1,583 · see citing works
Jankowsky, J. L., Fadale, D. J., Anderson, J., Xu, G. M., Gonzales, V., Jenkins, N. A., Copeland, N. G., Lee, M. K., Younkin, L. H., Wagner, S. L., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh019 · Cited by 1,575 · see citing works
Giasson, B. I., Duda, J. E., Murray, I. V. J., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q., & Lee, V. M. ‐. (2000) · Science · doi:10.1126/science.290.5493.985 · Cited by 1,551 · see citing works
Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A., & Ichijo, H. (2002) · Genes & Development · doi:10.1101/gad.992302 · Cited by 1,331 · see citing works
Engelman, J. A., Chen, L., Tan, X., Crosby, K., Guimaraes, A. R., Upadhyay, R., Maira, M., McNamara, K., Perera, S. A., Song, Y., et al. (2008) · Nature Medicine · doi:10.1038/nm.1890 · Cited by 1,330 · see citing works
Zhang, W., Wang, T., Pei, Z., Miller, D. S., Wu, X., Block, M. L., Wilson, B., Zhang, W., Zhou, Y., Hong, J.-S., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2751com · Cited by 1,265 · see citing works
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
West, A. B., Moore, D. J., Biskup, S., Bugayenko, A., Smith, W. W., Ross, C. A., Dawson, V. L., & Dawson, T. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507360102 · Cited by 1,228 · see citing works
ERAD: the long road to destruction
Meusser, B., Hirsch, C., Jarosch, E., & Sommer, T. (2005) · Nature Cell Biology · doi:10.1038/ncb0805-766 · Cited by 1,221 · see citing works
Regulation of matrix metalloproteinases: An overview
Chakraborti, S., Mandal, M., Das, S. K., Mandal, A., & Chakraborti, T. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1026028303196 · Cited by 1,123 · see citing works
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
Pasinelli, P., & Brown, R. H. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1971 · Cited by 1,107 · see citing works
Devi, L., Raghavendran, V., Prabhu, B. M., Avadhani, N. G., & Anandatheerthavarada, H. K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710012200 · Cited by 1,087 · see citing works
MAP kinases and cell migration
Huang, C., Jacobson, K., & Schaller, M. D. (2004) · Journal of Cell Science · doi:10.1242/jcs.01481 · Cited by 1,074 · see citing works
Mackenzie, I. R. A., Bigio, E. H., Ince, P. G., Geser, F., Neumann, M., Cairns, N. J., Kwong, L. K., Forman, M. S., Ravits, J., Stewart, H., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21147 · Cited by 992 · see citing works
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
Chipuk, J. E., & Green, D. R. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.01.007 · Cited by 982 · see citing works
ErbB receptors and signaling pathways in cancer
Hynes, N. E., & MacDonald, G. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.12.010 · Cited by 956 · see citing works
Parkinson's disease: from monogenic forms to genetic susceptibility factors
Lesage, S., & Brice, A. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp012 · Cited by 946 · see citing works
Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
Yu, G., Nishimura, M., Arawaka, S., Levitan, D. J., Zhang, L., Tandon, A., Song, Y., Rogaeva, E. A., Chen, F., Kawarai, T., et al. (2000) · Nature · doi:10.1038/35024009 · Cited by 906 · see citing works
Reactive Oxygen Species-Induced Activation of the MAP Kinase Signaling Pathways
McCubrey, J. A., LaHair, M. M., & Franklin, R. A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1775 · Cited by 804 · see citing works
Classic toxin-induced animal models of Parkinson?s disease: 6-OHDA and MPTP
Schober, A. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0938-y · Cited by 803 · see citing works
Non‐motor symptoms in Parkinson’s disease
Poewe, W. H. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02056.x · Cited by 790 · see citing works
Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals
Morrison, D. K., & Davis, R. J. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111401.091942 · Cited by 787 · see citing works
Chung, K. K. K., Zhang, Y., Lim, K. L., Tanaka, Y., Huang, H., Gao, J., Ross, C. A., Dawson, V. L., & Dawson, T. M. (2001) · Nature Medicine · doi:10.1038/nm1001-1144 · Cited by 750 · see citing works
Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
Caspersen, C., Wang, N., Yao, J., Sosunov, A., Chen, X., Lustbader, J. W., Xu, H. W., Stern, D., McKhann, G., & Du Yan, S. (2005) · The FASEB Journal · doi:10.1096/fj.05-3735fje · Cited by 738 · see citing works
Experimental models of Parkinson's disease
Beal, M. F. (2001) · Nature reviews. Neuroscience · doi:10.1038/35072550 · Cited by 634 · see citing works
Chen, L., & Feany, M. Β. (2005) · Nature Neuroscience · doi:10.1038/nn1443 · Cited by 614 · see citing works
Haigis, K. M., Kendall, K. R., Wang, Y., Cheung, A., Haigis, M. C., Glickman, J. N., Niwa-Kawakita, M., Sweet-Cordero, A., Sebolt-Leopold, J., Shannon, K. M., et al. (2008) · Nature Genetics · doi:10.1038/ng.115 · Cited by 610 · see citing works
Ley, R., Balmanno, K., Hadfield, K., Weston, C. R., & Cook, S. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301010200 · Cited by 609 · see citing works
Oxidative stress hypothesis in Alzheimer’s disease: a reappraisal
Praticò, D. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.09.001 · Cited by 606 · see citing works
Rethinking ALS: The FUS about TDP-43
Lagier‐Tourenne, C., & Cleveland, D. W. (2009) · Cell · doi:10.1016/j.cell.2009.03.006 · Cited by 590 · see citing works
FOXOs, cancer and regulation of apoptosis
Fu, Z., & Tindall, D. J. (2008) · Oncogene · doi:10.1038/onc.2008.24 · Cited by 584 · see citing works
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
Strauss, K. M., Martins, L. M., Plun‐Favreau, H., Marx, F. P., Kautzmann, S., Berg, D., Gasser, T., Wszolek, Z., Müller, T. H., Bornemann, A., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi215 · Cited by 569 · see citing works
Parkin Protects against the Toxicity Associated with Mutant α-Synuclein
Petrucelli, L., O’Farrell, C., Lockhart, P. J., Baptista, M. J., Kehoe, K. J., Vink, L., Choi, P., Wolozin, B. L., Farrer, M. J., Hardy, J., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)01125-x · Cited by 552 · see citing works
Boutros, T., Chevet, É., & Metrakos, P. P. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.00106 · Cited by 545 · see citing works
Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K., & Ichijo, H. (2008) · Genes & Development · doi:10.1101/gad.1640108 · Cited by 510 · see citing works
Tumour cell survival signalling by the ERK1/2 pathway
Balmanno, K., & Cook, S. J. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2008.148 · Cited by 484 · see citing works
DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase
Andrés‐Mateos, E., Perier, C., Zhang, L., Blanchard-Fillion, B., Greco, T. M., Thomas, B., Ko, H. S., Sasaki, M., Ischiropoulos, H., Przedborski, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703219104 · Cited by 478 · see citing works
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
Plun‐Favreau, H., Klupsch, K., Moisoi, N., Gandhi, S., Kjaer, S., Frith, D., Harvey, K., Deas, E., Harvey, R. J., McDonald, N. Q., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1644 · Cited by 476 · see citing works
Motoneuron Death Triggered by a Specific Pathway Downstream of Fas
Raoul, C., Estévez, Á. G., Nishimune, H., Cleveland, D. W., deLapeyrière, O., Henderson, C. E., Haase, G., & Pettmann, B. (2002) · Neuron · doi:10.1016/s0896-6273(02)00905-4 · Cited by 432 · see citing works
α-Synuclein and neuronal cell death
Cookson, M. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-9 · Cited by 420 · see citing works
Regulation and Role of Raf-1/B-Raf Heterodimerization
Rushworth, L. K., Hindley, A. D., O’Neill, E. E., & Kölch, W. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.6.2262-2272.2006 · Cited by 419 · see citing works
Microtubule-associated protein tau in development, degeneration and protection of neurons
Wang, J., & Liu, F. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.03.002 · Cited by 395 · see citing works
Martins, L. M., Morrison, A., Klupsch, K., Fedele, V., Moisoi, N., Teismann, P., Abuin, A., Grau, E., Geppert, M., Livi, G. P., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.9848-9862.2004 · Cited by 395 · see citing works
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
Xiong, H., Wang, D., Chen, L., Choo, Y. S., Ma, H., Tang, C., Xia, K., Jiang, W. B., Ronai, Z. A., Zhuang, X., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37617 · Cited by 394 · see citing works
The Role of Mitogen-Activated Protein Kinase Pathways in Alzheimer’s Disease
Zhu, X., Lee, H., Raina, A. K., Perry, G. L., & Smith, M. A. (2002) · Neurosignals · doi:10.1159/000067426 · Cited by 393 · see citing works
Liao, Y.-F., Wang, B.-J., Cheng, H.-T., Kuo, L.-H., & Wolfe, M. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402034200 · Cited by 389 · see citing works
Staropoli, J. F., McDermott, C., Martinat, C., Schulman, B. A., Demireva, E. Y., & Abeliovich, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00084-9 · Cited by 378 · see citing works
Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau
Melov, S., Adlard, P. A., Morten, K., Johnson, F., Golden, T. R., Hinerfeld, D., Schilling, B., Mavros, C., Masters, C. L., Volitakis, I., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000536 · Cited by 363 · see citing works
Tofaris, G. K., Razzaq, A., Ghetti, B. F., Lilley, K. S., & Spillantini, M. G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308041200 · Cited by 361 · see citing works
The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders
Aoki, Y., Niihori, T., Narumi, Y., Kure, S., & Matsubara, Y. (2008) · Human Mutation · doi:10.1002/humu.20748 · Cited by 360 · see citing works
Mitochondrial association of alpha-synuclein causes oxidative stress
Parihar, M. S., Parihar, A., Fujita, M., Hashimoto, M., & Ghafourifar, P. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7589-1 · Cited by 331 · see citing works
Tofaris, G. K., Garcia-Reitboeck, P., Humby, T., Lambourne, S. L., O’Connell, M. T., Ghetti, B. F., Gossage, H., Emson, P. C., Wilkinson, L. S., Goedert, M., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4965-05.2006 · Cited by 325 · see citing works
Tamagno, E., Parola, M., Bardini, P., Piccini, A., Borghi, R., Guglielmotto, M., Santoro, G., Davit, A., Danni, O., Smith, M. A., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02895.x · Cited by 324 · see citing works
Mitochondrial localization of DJ‐1 leads to enhanced neuroprotection
Junn, E., Jang, W. H., Zhao, X., Jeong, B. S., & Mouradian, M. M. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.21831 · Cited by 320 · see citing works
Parkinson's disease and pesticides: a toxicological perspective
Hatcher, J. M., Pennell, K. D., & MILLER, G. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.03.007 · Cited by 319 · see citing works
The mitochondrial serine protease HtrA2/Omi: an overview
Walle, L. V., Lamkanfi, M., & Vandenabeele, P. (2008) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402291 · Cited by 318 · see citing works
Cesari, R., Martin, E. S., Calin, G. A., Pentimalli, F., Bichi, R., McAdams, H., Trapasso, F., Drusco, A., Shimizu, M., Masciullo, V., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931262100 · Cited by 314 · see citing works
Cicchetti, F., Drouin‐Ouellet, J., & Gross, R. E. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.06.005 · Cited by 312 · see citing works
Molecular and cellular pathways of neurodegeneration in motor neurone disease
Shaw, P. J. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.048652 · Cited by 310 · see citing works
Oxidative and Inflammatory Pathways in Parkinson’s Disease
Miller, R. L., James-Kracke, M., Sun, G. Y., & Sun, A. Y. (2009) · Neurochemical Research · doi:10.1007/s11064-008-9656-2 · Cited by 306 · see citing works
Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease
The Parkinson Study Group PRECEPT Investigators (2007) · Neurology · doi:10.1212/01.wnl.0000277648.63931.c0 · Cited by 296 · see citing works
Mechanisms of Disease: autosomal dominant and recessive polycystic kidney diseases
Torres, V. E., & Harris, P. C. (2006) · Nature Reviews Nephrology · doi:10.1038/ncpneph0070 · Cited by 288 · see citing works
Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps
Levy, O. A., Malagelada, C., & Greene, L. A. (2009) · APOPTOSIS · doi:10.1007/s10495-008-0309-3 · Cited by 287 · see citing works
Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential
Bogoyevitch, M. A., Boehm, I., Oakley, A. J., Ketterman, A. J., & Barr, R. K. (2003) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2003.11.016 · Cited by 268 · see citing works
Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila
Cha, G., Kim, S., Park, J., Lee, E., Kim, M., Lee, S. B., Kim, J., Chung, J., & Cho, K. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500346102 · Cited by 261 · see citing works
Molecular pathogenesis of Parkinson's disease
Gandhi, S., & Wood, N. W. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi308 · Cited by 251 · see citing works
Xu, J., Zhong, N., Wang, H., Elias, J. E., Kim, C. Y., Woldman, I., Pifl, C., Gygi, S. P., Geula, C., & Yankner, B. A. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi134 · Cited by 250 · see citing works
ERK MAP kinase in G1 cell cycle progression and cancer
Torii, S., Yamamoto, T., Tsuchiya, Y., & Nishida, E. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00244.x · Cited by 249 · see citing works
Amyloid precursor protein promotes post‐developmental neurite arborization in the Drosophila brain
Leyssen, M., Ayaz, D., Hébert, S. S., Reeve, S. P., Strooper, B. D., & Hassan, B. A. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600757 · Cited by 245 · see citing works
Tabner, B. J., El‐Agnaf, O. M. A., Turnbull, S., German, M. J., Paleologou, K. E., Hayashi, Y., Cooper, L. J., Fullwood, N. J., & Allsop, D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.c500238200 · Cited by 241 · see citing works
Pathophysiological Roles of ASK1-MAP Kinase Signaling Pathways
Nagai, H., Noguchi, T., Takeda, K., & Ichijo, H. (2007) · BMB Reports · doi:10.5483/bmbrep.2007.40.1.001 · Cited by 239 · see citing works
Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis
Jiang, H., Ren, Y., Zhao, J., & Feng, J. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh180 · Cited by 239 · see citing works
Peng, J., Mao, X. O., Stevenson, F. F., Hsu, M., & Andersen, J. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404596200 · Cited by 234 · see citing works
Saporito, M. S., Thomas, B. A., & Scott, R. W. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0751200.x · Cited by 233 · see citing works
Animal models of Parkinson’s disease progression
Meredith, G. E., Sonsalla, P. K., & Chesselet, M. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0350-x · Cited by 228 · see citing works
α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia
Klegeris, A., Pelech, S., Giasson, B. I., Maguire, J., Zhang, H., McGeer, E. G., & McGeer, P. L. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.11.013 · Cited by 227 · see citing works
Munoz, L., Ranaivo, H. R., Roy, S. M., Hu, W., Craft, J. M., McNamara, L. K., Chico, L. W., Van Eldik, L. J., & Watterson, D. M. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-21 · Cited by 224 · see citing works
The Non-Amyloidogenic Pathway: Structure and Function of α-Secretases
Kojro, E., & Fahrenholz, F. (2006) · Springer eBooks · doi:10.1007/0-387-23226-5_5 · Cited by 211 · see citing works
MIXED LINEAGE KINASE INHIBITOR CEP- 1347 FAILS TO DELAY DISABILITY IN EARLY PARKINSON DISEASE
Wang, L. H., & Johnson, E. M. (2008) · Neurology · doi:10.1212/01.wnl.0000324506.93877.5e · Cited by 202 · see citing works
Unique Biology of Mcl-1: Therapeutic Opportunities in Cancer
Shore, G. C., & Warr, M. R. (2008) · Current Molecular Medicine · doi:10.2174/156652408783769580 · Cited by 193 · see citing works
Polo-like Kinase 2 (PLK2) Phosphorylates α-Synuclein at Serine 129 in Central Nervous System
Inglis, K. J., Chéreau, D., Brigham, E., Chiou, S., Schöbel, S., Frigon, N., Yu, M., Caccavello, R., Nelson, S., Motter, R., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.c800206200 · Cited by 188 · see citing works
Gloeckner, C. J., Schumacher, A., Boldt, K., & Ueffing, M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06024.x · Cited by 187 · see citing works
Regulation of astrocyte inflammatory responses by the Parkinson's disease‐associated gene DJ–1
Waak, J., Weber, S. S., Waldenmaier, A., Görner, K., Alunni‐Fabbroni, M., Schell, H., Weisenhorn, D. M. V., Pham, T., Reumers, V., Baekelandt, V., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-125153 · Cited by 186 · see citing works
Why have we failed to achieve neuroprotection in Parkinson's disease?
Olanow, C. W., Kieburtz, K. D., & Schapira, A. H. V. (2009) · Annals of Neurology · doi:10.1002/ana.21461 · Cited by 184 · see citing works
Tortarolo, M., Veglianese, P., Calvaresi, N., Botturi, A., Rossi, C., Giorgini, A., Migheli, A., & Bendotti, C. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00022-8 · Cited by 180 · see citing works
Marques, C. A., Keil, U., Bonert, A., Steiner, B., Haass, C., Müller, W. E., & Eckert, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212265200 · Cited by 175 · see citing works
Induction of neuronal death by α‐synuclein
Saha, R. A., Ninkina, N. N., Hanger, D. P., Anderton, B. H., Davies, A. M., & Buchman, V. L. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00210.x · Cited by 169 · see citing works
The JIP family of MAPK scaffold proteins
Whitmarsh, A. J. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340828 · Cited by 169 · see citing works
Hydrogen Peroxide Promotes Aβ Production through JNK-dependent Activation of γ-Secretase
Shen, C., Chen, Y., Liu, H., Zhang, K., Zhang, T., Lin, A., & Jing, N. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800013200 · Cited by 168 · see citing works
JNK regulates APP cleavage and degradation in a model of Alzheimer's disease
Colombo, A. V., Bastone, A., Ploia, C., Sclip, A., Salmona, M., Forloni, G., & Borsello, T. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.12.014 · Cited by 158 · see citing works
Newhouse, K. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh089 · Cited by 157 · see citing works
Klegeris, A., Giasson, B. I., Zhang, H., Maguire, J. A., Pelech, S., & McGeer, P. L. (2006) · The FASEB Journal · doi:10.1096/fj.06-6183com · Cited by 143 · see citing works
Ramachandiran, S., Hansen, J. M., Jones, D. P., Richardson, J., & Miller, G. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfl125 · Cited by 143 · see citing works
Tau Therapeutic Strategies for the Treatment of Alzheimers Disease
Churcher, I. (2006) · Current Topics in Medicinal Chemistry · doi:10.2174/156802606776743057 · Cited by 142 · see citing works
The ASK1-MAP Kinase Signaling in ER Stress and Neurodegenerative Diseases
Sekine, Y., Takeda, K., & Ichijo, H. (2006) · Current Molecular Medicine · doi:10.2174/156652406775574541 · Cited by 142 · see citing works
Karunakaran, S., Diwakar, L., Saeed, U., Agarwal, V., Ramakrishnan, S., Iyengar, S., & Ravindranath, V. (2007) · The FASEB Journal · doi:10.1096/fj.06-7580com · Cited by 140 · see citing works
Ouyang, M., & Shen, X. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03730.x · Cited by 139 · see citing works
Karunakaran, S., Saeed, U., Mishra, M., Valli, R. K., Joshi, S. D., Meka, D. P., Seth, P., & Ravindranath, V. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4511-08.2008 · Cited by 134 · see citing works
Dewil, M., dela Cruz, V. F., Van Den Bosch, L., & Robberecht, W. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.023 · Cited by 133 · see citing works
Zhu, J., Zhong, W., Zhang, G.-C., Li, R., Zhang, X., Guo, A., Zhang, Y.-F., An, S., Mok, T. S. K., & Wu, Y.-L. L. C. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.02.064 · Cited by 129 · see citing works
Alzheimer's Disease: cholesterol, membrane rafts, isoprenoids and statins
Reid, P., Urano, Y., Kodama, T., & Hamakubo, T. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00054.x · Cited by 129 · see citing works
Targeting JNK3 for the treatment of neurodegenerative disorders
Resnick, L., & Fennell, M. (2004) · Drug Discovery Today · doi:10.1016/s1359-6446(04)03251-9 · Cited by 128 · see citing works
Somatic Mutations of Epidermal Growth Factor Receptor in Colorectal Carcinoma
Nagahara, H., Mimori, K., Ohta, M., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1894 · Cited by 126 · see citing works
Raoul, C., Buhler, E., Sadeghi, C., Jacquier, A., Aebischer, P., Pettmann, B., Henderson, C. E., & Haase, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508774103 · Cited by 116 · see citing works
Pathophysiology of Neurodegeneration in Familial Amyotrophic Lateral Sclerosis
Vucic, S., & Kiernan, M. C. (2009) · Current Molecular Medicine · doi:10.2174/156652409787847173 · Cited by 113 · see citing works
Ackerley, S., Grierson, A. J., Banner, S. J., Perkinton, M. S., Brownlees, J., Byers, H. L., Ward, M. A., Thornhill, P., Hussain, K., Waby, J. S., et al. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.02.009 · Cited by 112 · see citing works
Bendotti, C., Atzori, C., Piva, R., Tortarolo, M., Strong, M. J., Debiasi, S., & Migheli, A. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.2.113 · Cited by 103 · see citing works
Wiring diagrams of MAPK regulation by MEKK1, 2, and 3
Uhlik, M. T., Abell, A. N., Cuevas, B. D., Nakamura, K., & Johnson, G. L. (2004) · Biochemistry and Cell Biology · doi:10.1139/o04-114 · Cited by 101 · see citing works
Targeting the JNK Signaling Pathway for Stroke and Parkinsons Diseases Therapy
Kuan, C.-Y., & Burke, R. E. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007053005145 · Cited by 100 · see citing works
Involvement of c‐Jun N‐terminal kinase in amyloid precursor protein‐mediated neuronal cell death
Hashimoto, Y., Tsuji, O., Niikura, T., Yamagishi, Y., Ishizaka, M., Kawasumi, M., Chiba, T., Kanekura, K., Yamada, M., Tsukamoto, E., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01585.x · Cited by 99 · see citing works
Saporito, M. S., Hudkins, R. L., & Maroney, A. C. (2002) · Progress in medicinal chemistry · doi:10.1016/s0079-6468(08)70081-x · Cited by 99 · see citing works
Brownlees, J., Yates, A., Bajaj, N. P. S., Davis, D. R., Anderton, B. H., Leigh, P. N., Shaw, C. E., & Miller, C. C. J. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.3.401 · Cited by 98 · see citing works
Biochemical aspects of the neuroprotective mechanism of PTEN‐induced kinase‐1 (PINK1)
Mills, R. D., Sim, C. H., Mok, S. S., Mulhern, T. D., Culvenor, J. G., & Cheng, H. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05249.x · Cited by 93 · see citing works
One Hundred Years after the Discovery of Alzheimer's Disease. A Turning Point for Therapy?
Giacobini, E., & Becker, R. E. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-12105 · Cited by 92 · see citing works
Zebisch, A., Staber, P. B., Delavar, A., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-0115 · Cited by 91 · see citing works
Placanica, L., Zhu, L., & Li, Y. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005088 · Cited by 88 · see citing works
Silva, R. M., Kuan, C.-Y., RAKIC, P. T., & Burke, R. E. (2005) · Movement Disorders · doi:10.1002/mds.20390 · Cited by 87 · see citing works
Yun, J., Cao, J. H., Dodson, M. W., Clark, I. E., Kapahi, P., Chowdhury, R. B., & Guo, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5141-08.2008 · Cited by 85 · see citing works
Puig, B., Gómez‐Isla, T., Ribé, E. M., Cuadrado‐Tejedor, M., Torrejón-Escribano, B., Dalfó, E., & Ferrer, I. (2004) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2004.00569.x · Cited by 85 · see citing works
JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1
Tamagno, E., Guglielmotto, M., Giliberto, L., Vitali, A., Borghi, R., Autelli, R., Danni, O., & Tabaton, M. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.12.015 · Cited by 84 · see citing works
Hsuan, S., Klintworth, H. M., & Xia, Z. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4922-05.2006 · Cited by 81 · see citing works
Targeting RAS and PI3K in lung cancer
Downward, J. (2008) · Nature Medicine · doi:10.1038/nm1208-1315 · Cited by 80 · see citing works
Klintworth, H. M., Newhouse, K., Li, T., et al. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm029 · Cited by 80 · see citing works
Magnetic Resonance Spectroscopy Monitoring of Mitogen-Activated Protein Kinase Signaling Inhibition
Beloueche‐Babari, M., Jackson, L. E., Al-Saffar, N. M. S., et al. (2005) · Cancer Research · doi:10.1158/10.1158/0008-5472.can-03-2981 · Cited by 80 · see citing works
Therapeutic strategies for inhibiting oncogenic BRAF signaling
Halilovic, E., & Solit, D. B. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.06.014 · Cited by 79 · see citing works
MAPK‐pathway activity, Lrrk2 G2019S, and Parkinson's disease
White, L. R., Toft, M., Kvam, S. N., Farrer, M. J., & Aasly, J. O. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21240 · Cited by 78 · see citing works
Lim, M. K., Kawamura, T., Ohsawa, Y., Ohtsubo, M., Asakawa, S., Takayanagi, A., & Shimizu, N. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.04.016 · Cited by 76 · see citing works
Cuevas, B. D., Winter-Vann, A. M., Johnson, N. L., & Johnson, G. L. (2006) · Oncogene · doi:10.1038/sj.onc.1209507 · Cited by 76 · see citing works
Oncogenic K‐ras promotes early carcinogenesis in the mouse proximal colon
Calcagno, S. R., Li, S., Colon, M., Kreinest, P. A., Thompson, E. A., Fields, A. P., & Murray, N. R. (2008) · International Journal of Cancer · doi:10.1002/ijc.23383 · Cited by 68 · see citing works
Voisin, L., Julien, C., Duhamel, S., Gopalbhai, K., Claveau, I., Saba-El-Leil, M. K., Rodrigue‐Gervais, I. G., Gaboury, L. A., Lamarre, D., Basik, M., et al. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-337 · Cited by 67 · see citing works
Tumorigenesis and neurodegeneration: two sides of the same coin?
Staropoli, J. F. (2008) · BioEssays · doi:10.1002/bies.20784 · Cited by 67 · see citing works
Paulson, J. B., Ramsden, M., Forster, C. L., Sherman, M. A., McGowan, E. M., & Ashe, K. H. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080175 · Cited by 67 · see citing works
Holasek, S. S., Wengenack, T. M., Kandimalla, K. K., Montaño, C., Gregor, D. M., Curran, G. L., & Poduslo, J. F. (2005) · Brain Research · doi:10.1016/j.brainres.2005.03.037 · Cited by 64 · see citing works
Chaparro, M., MORENO, L. G., Trapero-Marugán, M., MEDINA, J., & Moreno‐Otero, R. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03857.x · Cited by 63 · see citing works
DJ-1 modulates UV-induced oxidative stress signaling through the suppression of MEKK1 and cell death
Mo, J.-S., Kim, M.-Y., Ann, E.-J., Hong, J.-A., & Park, H.-S. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.26 · Cited by 62 · see citing works
The molecular link between β- and γ-secretase activity on the amyloid β precursor protein
Tabaton, M., & Tamagno, E. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7219-3 · Cited by 59 · see citing works
Zucchelli, S., Vilotti, S., Calligaris, R., Lavina, Z. S., Biagioli, M., Foti, R., Maso, L. D., Pinto, M., Gorza, M., Speretta, E., et al. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.169 · Cited by 53 · see citing works
A Disease State Mutation Unfolds the Parkin Ubiquitin-like Domain
Safadi, S. S., & Shaw, G. S. (2007) · Biochemistry · doi:10.1021/bi7016969 · Cited by 52 · see citing works
Transforming Growth Factor β2 Is a Neuronal Death-Inducing Ligand for Amyloid-β Precursor Protein
Hashimoto, Y., Chiba, T., Yamada, M., Nawa, M., Kanekura, K., Suzuki, H., Terashita, K., Aiso, S., Nishimoto, I., & Matsuoka, M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.21.9304-9317.2005 · Cited by 51 · see citing works
Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells
Mathiasen, J. R., McKenna, B. A., Saporito, M. S., et al. (2004) · Brain Research · doi:10.1016/j.brainres.2003.11.073 · Cited by 50 · see citing works
Muresan, Z. L., & Mureşan, V. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-07-0625 · Cited by 50 · see citing works
Tau Phosphorylation in Alzheimer's Disease: Potential Involvement of an APP–MAP Kinase Complex
Peel, A. L., Sorscher, N., Kim, J. Y., Galván, V., Chen, S., & Bredesen, D. E. (2004) · NeuroMolecular Medicine · doi:10.1385/nmm:5:3:205 · Cited by 47 · see citing works
Hudkins, R. L., Diebold, J. L., Tao, M., Josef, K. A., Park, C. H., Angeles, T. S., Aimone, L. D., Husten, J., Ator, M. A., Meyer, S. L., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm8005838 · Cited by 47 · see citing works
Leucine-rich repeat kinase 2: Relevance to Parkinson's disease
Guo, L., Wang, W., & Chen, S. G. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.02.009 · Cited by 46 · see citing works
Parkin mitochondria in the autophagosome
McBride, H. M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200810184 · Cited by 45 · see citing works
The TAT-JNK inhibitor peptide interferes with beta amyloid protein stability
Colombo, A. V., Repici, M., Pesaresi, M., et al. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402202 · Cited by 44 · see citing works
Pan, J., Zhao, Y.-X., Wang, Z., Jin, L., Sun, Z.-K., & Chen, S.-D. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.09.032 · Cited by 42 · see citing works
Chiarini, A., Prà, I. D., Marconi, M., et al. (2009) · Current Pharmaceutical Biotechnology · doi:10.2174/138920109787847501 · Cited by 40 · see citing works
Bendotti, C., Cutrona, M. B., Cheroni, C., Grignaschi, G., Coco, D. L., Peviani, M., Tortarolo, M., Veglianese, P., & Zennaro, E. (2005) · Neurodegenerative Diseases · doi:10.1159/000089617 · Cited by 39 · see citing works
From Extracellular to Intracellular Targets, Inhibiting MAP Kinases in Treatment of Crohn's Disease
van den Blink, B., ten Hove, T., BRINK, G. R. V. D., et al. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04664.x · Cited by 25 · see citing works
Phosphorylated tau in neuritic plaques of APPsw/Tauvlw transgenic mice and Alzheimer disease
Pérez, M., Morán, M. A., Ferrer, I., Ávila, J., & Gómez‐Ramos, P. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0420-0 · Cited by 23 · see citing works
Inhibition of JNK increases survival of transplanted dopamine neurons in Parkinsonian rats
Rawal, N., Parish, C. L., Castelo‐Branco, G., et al. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402010 · Cited by 23 · see citing works
Interaction of ASK1 and the β-amyloid precursor protein in a stress-signaling complex
Galván, V., Banwait, S., Spilman, P. R., Gorostiza, O. F., Peel, A. L., Ataie, M., Crippen, D., Huang, W., Sidhu, G., Ichijo, H., et al. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.06.017 · Cited by 19 · see citing works
Emerging Therapeutic Targets in Non-Small Cell Lung Cancer
Dy, G. K., & Adjei, A. A. (2009) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200808-099lc · Cited by 19 · see citing works
The structure and functions of the presenilins
Dewji, N. N. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-4566-9 · Cited by 18 · see citing works
Pesticide use linked to Parkinson's disease
Adam, D. (2000) · Nature · doi:10.1038/35041740 · Cited by 11 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?
Son, Y., Cheong, Y.-K., Kim, N.-H., Chung, H.-T., Kang, D. G., & Pae, H.-O. (2011) · Journal of Signal Transduction · doi:10.1155/2011/792639 · Cited by 1,219 · see citing works
Dopamine: Functions, Signaling, and Association with Neurological Diseases
Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0632-3 · Cited by 1,073 · see citing works
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer
Wu, F., Yang, J., Liu, J., Wang, Y., Mu, J., Zeng, Q., Deng, S., & Zhou, H. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00641-0 · Cited by 773 · see citing works
Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression
Bai, B., Wang, X., Li, Y., Chen, P.-C., Yu, K., Dey, K. K., Yarbro, J. M., Han, X., Lutz, B. M., Rao, S., et al. (2020) · Neuron · doi:10.1016/j.neuron.2019.12.015 · Cited by 632 · see citing works
“Collectively, these multilevel proteomic analyses suggest the activation of MAP kinase signaling that is implicated in AD pathogenesis (Kim and Choi, 2010).”
BackgroundDifferential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
Smith, B. E., Wang, S. L., Jaime-Figueroa, S., Harbin, A., Wang, J., Hamman, B. D., & Crews, C. M. (2019) · Nature Communications · doi:10.1038/s41467-018-08027-7 · Cited by 517 · see citing works
Stefani, C., Miricescu, D., Stanescu-Spinu, I.-I., Nica, R. I., Greabu, M., Totan, A. R., & Jinga, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910260 · Cited by 402 · see citing works
S100A8/A9 activate key genes and pathways in colon tumor progression
Ichikawa, M., Williams, R., Wang, L., Vogl, T., & Srikrishna, G. (2011) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-10-0394 · Cited by 346 · see citing works
Molecular basis of MAP kinase regulation
Peti, W., & Page, R. (2013) · Protein Science · doi:10.1002/pro.2374 · Cited by 302 · see citing works
“ities in MAPK signaling pathways, including Parkinson’s, inflammatory disorders and cancer.(4,5) As”
BackgroundRole of p38/MAPKs in Alzheimer's Disease: Implications for Amyloid Beta Toxicity Targeted Therapy
Kheiri, G., Dolatshahi, M., Rahmani, F., & Rezaei, N. (2018) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0008 · Cited by 211 · see citing works
Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology
Maphis, N., Jiang, S., Xu, G., Kokiko-Cochran, O. N., Roy, S. M., Van Eldik, L. J., Watterson, D. M., Lamb, B. T., & Bhaskar, K. (2016) · Alzheimer's Research & Therapy · doi:10.1186/s13195-016-0221-y · Cited by 144 · see citing works
“…synthase kinase 3 beta (GSK-3 β ), cyclin-dependent kinase 5 (Cdk5), microtubule affinity regulating kinase 1 – 4 (MARK1 – MAPK4), extracellular signal-related kinase (ERK), p38 mitogen-associated protein kinase alpha (p38 α MAPK), and c-Jun N-terminal kinase (JNK) are the best examples [19 – 21].”
Apolloni, S., Amadio, S., Montilli, C., Volonte, C., & D'Ambrosi, N. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt259 · Cited by 109 · see citing works
Fang, F., Yu, Q., Arancio, O., Chen, D., Gore, S. S., Yan, S. S., & Yan, S. F. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy017 · Cited by 103 · see citing works
Garwood, C. J., Ratcliffe, L. E., Morgan, S. V., Simpson, J. E., Owens, H., Vazquez-Villaseñor, I., Heath, P. R., Romero, I. A., Ince, P. G., & Wharton, S. B. (2015) · Molecular Brain · doi:10.1186/s13041-015-0138-6 · Cited by 101 · see citing works
Faucher, P., Mons, N., Micheau, J., Louis, C., & Beracochea, D. J. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00245 · Cited by 100 · see citing works
Role of JNK signaling in oral cancer: A mini review
Gkouveris, I., & Nikitakis, N. G. (2017) · Tumor Biology · doi:10.1177/1010428317711659 · Cited by 87 · see citing works
Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury
Syc-Mazurek, S. B., Fernandes, K. A., Wilson, M. P., Shrager, P., & Libby, R. T. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0214-8 · Cited by 74 · see citing works
Shared genetic etiology underlying Alzheimer’s disease and type 2 diabetes
Hao, K., Di Narzo, A. F., Ho, L., Luo, W., Li, S., Chen, R., Li, T., Dubner, L., & Pasinetti, G. M. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2015.06.006 · Cited by 84 · see citing works
Structural basis of p38α regulation by hematopoietic tyrosine phosphatase
Francis, D. M., Różycki, B., Koveal, D., Hummer, G., Page, R., & Peti, W. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.707 · Cited by 79 · see citing works
Identification of Conserved Proteomic Networks in Neurodegenerative Dementia
Swarup, V., Chang, T. S., Duong, D. M., Dammer, E. B., Dai, J., Lah, J. J., Johnson, E. C. B., Seyfried, N. T., Levey, A. I., & Geschwind, D. H. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107807 · Cited by 78 · see citing works
Identification of conserved proteomic networks in neurodegenerative dementia
Swarup, V., Chang, T. S., Duong, D. M., Dammer, E. B., Lah, J. J., Johnson, E. E. C. B., Seyfried, N. T., Levey, A. I., & Geschwind, D. H. (2019) · doi:10.1101/825802 · Cited by 78 · see citing works
Liu, X., Du, Z. R., Wang, X., Sun, X. R., Zhao, Q., Zhao, F., Wong, W. T., Wong, K. H., & Dong, X.-L. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111067 · Cited by 77 · see citing works
Dong, X.-L., Wang, X., Liu, F., Liu, X., Du, Z.-R., Li, R. W., Xue, C.-H., Wong, K.-H., Wong, W.-T., Zhao, Q., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.180 · Cited by 75 · see citing works
Park, H. R., Lee, H., Park, H., Jeon, J. W., Cho, W.-K., & Ma, J. Y. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0679-3 · Cited by 68 · see citing works
Ye, M.-J., & Meng, N. (2021) · Bioengineered · doi:10.1080/21655979.2021.1954742 · Cited by 43 · see citing works
Neuroprotective mechanisms of mangiferin in neurodegenerative diseases
Liu, T., Song, Y., & Hu, A. (2021) · Drug Development Research · doi:10.1002/ddr.21783 · Cited by 43 · see citing works
Beydoun, T., Deloche, C., Perino, J., Kirwan, B.-A., Combette, J.-M., & Behar-Cohen, F. (2015) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2013.0247 · Cited by 39 · see citing works
Li, J., Dai, G., Cheng, Y.-B., Qi, X., & Geng, M.-Y. (2011) · Glycobiology · doi:10.1093/glycob/cwr020 · Cited by 37 · see citing works
Deloche, C., Lopez‐Lazaro, L., Mouz, S., Perino, J., Abadie, C., & Combette, J. (2014) · Pharmacology Research & Perspectives · doi:10.1002/prp2.20 · Cited by 37 · see citing works
Resting and Active States of the ERK2:HePTP Complex
Francis, D. M., Różycki, B., Tortajada, A., Hummer, G., Peti, W., & Page, R. (2011) · Journal of the American Chemical Society · doi:10.1021/ja2075136 · Cited by 32 · see citing works
Unlocking the multifaceted roles of GLP-1: Physiological functions and therapeutic potential
AL-Noshokaty, T. M., Abdelhamid, R., Abdelmaksoud, N. M., Khaled, A., Hossam, M., Ahmed, R., Saber, T., Khaled, S., Elshaer, S. S., & Abulsoud, A. I. (2025) · Toxicology Reports · doi:10.1016/j.toxrep.2025.101895 · Cited by 30 · see citing works
Syc-Mazurek, S. B., Rausch, R. L., Fernandes, K. A., Wilson, M. P., & Libby, R. T. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-1079-7 · Cited by 29 · see citing works
Pyakurel, A., Balmer, D., Saba-El-Leil, M. K., Kizilyaprak, C., Daraspe, J., Humbel, B. M., Voisin, L., Le, Y. Z., von Lintig, J., Meloche, S., et al. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00295-17 · Cited by 20 · see citing works
α-Ionone Protects Against UVB-Induced Photoaging in Human Dermal Fibroblasts
Tong, T., Park, J., Moon, Y., Kang, W., & Park, T. (2019) · Molecules · doi:10.3390/molecules24091804 · Cited by 28 · see citing works
Zeng, S., Zhang, T., Chen, Y., Chu-Tan, J., Jin, K., Lee, S.-R., Yam, M. X., Madigan, M. C., Fernando, N., Cioanca, A., et al. (2022) · Theranostics · doi:10.7150/thno.71038 · Cited by 22 · see citing works
Francis, D. M., Kumar, G. S., Koveal, D., Tortajada, A., Page, R., & Peti, W. (2013) · Structure · doi:10.1016/j.str.2013.07.003 · Cited by 21 · see citing works
Mammone, T., Chidlow, G., Casson, R. J., & Wood, J. P. M. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.01.002 · Cited by 18 · see citing works
Mageau, E., Derbowka, R., Dickinson, N., Lefort, N., Kovala, A. T., Boreham, D. R., Tai, T. C., Thome, C., & Tharmalingam, S. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47080589 · Cited by 12 · see citing works
Protein kinase inhibitors as therapeutics in neurodegenerative and psychiatric disorders
Tridente, G., Jana, A., Nath, A., & Ashraf, G. M. (2023) · Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders · doi:10.1016/b978-0-443-18677-6.00015-4 · Cited by 8 · see citing works
Balmer, D., Bapst-Wicht, L., Pyakurel, A., Emery, M., Nanchen, N., Bochet, C. G., & Roduit, R. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00043 · Cited by 6 · see citing works
- Authors
- Kim, E. K., & Choi, E.-J.
- Affiliations
- Korea University (KR)
- Corresponding author
- Choi, Eui-Ju
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 1802
- Issue
- 4
- Pages
- 396-405
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W2133801172
- Cited by
- 2,472
- References
- 177
- Citations by year
- 2026: 94 · 2025: 207 · 2024: 217 · 2023: 192 · 2022: 156 · 2021: 210 · 2020: 180 · 2019: 162 · 2018: 189 · 2017: 131 · 2016: 135 · 2015: 114 · 2014: 131 · 2013: 107 · 2012: 100
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Funders
- Ministry of Education, Science and Technology
- National Research Foundation of Korea (2009-0067112, 2009-0080895, 20090081488, KRF-2006-341-C00023)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- MAPK signaling, ERK, p38 MAPK, JNK, MAP3K, MEK, neurodegenerative diseases, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, cancer, neuronal apoptosis, oxidative stress, endoplasmic reticulum stress, carcinogenesis, cell proliferation and migration
- MeSH terms
- Humans, Neoplasms, Cytokines, Oxidative Stress, Neurodegenerative Diseases, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, Intercellular Signaling Peptides and Proteins, Unfolded Protein Response
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
