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Cited by 171Child and Adolescent Psychosocial and Emotional DevelopmentPsychopathy, Forensic Psychiatry, Sexual OffendingCrime Patterns and Interventions

The DOI matches its Crossref record; 20 of the 21 references it cites were found in a registry or an index.

Family Dysfunction Interacts with Genes in the Causation of Antisocial Symptoms

Button, Tanya Maria May, Scourfield, Jane, Martin, Neilson, Purcell, Shaun, McGuffin, Peter·2005·Behavior Genetics
DOI 10.1007/s10519-004-0826-y
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Abstract

There is emerging evidence of gene-environment interaction effects on conduct problems, both from adoption studies and from a study using a measured genotype. An association between non-violent family dysfunction and conduct problems has also been reported, although not in the context of gene-environment interaction studies. The aim of this study was to examine the interaction of genes and family dysfunction in contributing to conduct problems in young people. Parents of 278 monozygotic and 378 dizygotic twin pairs, aged 5-18, from the CaStANET birth cohort twin register were questioned about zygosity, conduct problems and family environment. Using structural equation modeling we tested for main and interactive effects of genes and family dysfunction modelled as an environmental "moderator variable". Both main and gene-environment interaction effects were highly significant. It was concluded that a risk genotype conferring susceptibility to family dysfunction is responsible for most of the variance in antisocial symptoms in childhood and adolescence.

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Citations

Cites

Research works printed but not linked: 2

  1. T. E. Moffitt, 2002, Quantitative Behavioural Genetic Research into Human Antisocial Behaviour Genetics and Human Behaviour the Ethical Context, 89
  2. M. C. Neale, 1997, Mx:Statistcal Modeling

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Metadata

Authors
Button, T. M. M., Scourfield, J., Martin, N., Purcell, S., & McGuffin, P.
Affiliations
  • King's College London (GB)
  • University of Wales (GB)
  • Curtin University (AU)
  • Whitehead Institute for Biomedical Research (US)
Corresponding author
Button, Tanya Maria May
ORCID
Venue
Behavior Genetics
Publisher
Springer Science and Business Media LLC
Published
2005-03
Volume
35
Issue
2
Pages
115-120
ISSN
  • 0001-8244 (ISSN-L)
  • 1573-3297
DOI
10.1007/s10519-004-0826-y
OpenAlex
W1972016902
Cited by
171
References
21
Citations by year
2023: 3 · 2022: 27 · 2021: 1 · 2020: 18 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 5
FWCI
22.45
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Behavior Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
Medical Research Council
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
  • Social Sciences › Sociology and Political Science › Crime Patterns and Interventions
Keywords
gene-environment interaction, family dysfunction, conduct problems, monozygotic twins, dizygotic twins, zygosity, family environment, risk genotype, childhood and adolescence
MeSH terms
Antisocial Personality Disorder, Family, Humans, Interpersonal Relations, Models, Genetic, Models, Psychological, Social Behavior

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