The DOI matches its Crossref record; 416 of the 416 references it cites were found in a registry or an index.
The role of estrogen deficiency in skin ageing and wound healing
Abstract
The links between hormonal signalling and lifespan have been well documented in a range of model organisms. For example, in C. elegans or D. melanogaster, lifespan can be modulated by ablating germline cells, or manipulating reproductive history or pregnenolone signalling. In mammalian systems, however, hormonal contribution to longevity is less well understood. With increasing age human steroid hormone profiles change substantially, particularly following menopause in women. This article reviews recent links between steroid sex hormones and ageing, with special emphasis on the skin and wound repair. Estrogen, which substantially decreases with advancing age in both males and females, protects against multiple aspects of cellular ageing in rodent models, including oxidative damage, telomere shortening and cellular senescence. Estrogen's effects are particularly pronounced in the skin where cutaneous changes post-menopause are well documented, and can be partially reversed by classical Hormone Replacement Therapy (HRT). Our research shows that while chronological ageing has clear effects on skin wound healing, falling estrogen levels are the principle mediator of these effects. Thus, both HRT and topical estrogen replacement substantially accelerate healing in elderly humans, but are associated with unwanted deleterious effects, particularly cancer promotion. In fact, much current research effort is being invested in exploring the therapeutic potential of estrogen signalling manipulation to reverse age-associated pathology in peripheral tissues. In the case of the skin the differential targeting of estrogen receptors to promote healing in aged subjects is a real therapeutic possibility.
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In the citing paper
“Falling estrogen levels, for instance, may be the principal cause of age-related healing impairment in both males and females (112).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [112]
In the citing paper
“Hormones, particularly estrogens and androgens, are contributing factors in aging and have been implicated as regulators of wound healing in experimental models and patients (112, 163, 172, 173).”
From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [112]
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1 retracted
Items 401–416 of 416
Sakuraoka, K., Tajima, S., Seyama, Y., et al. (1996) · Journal of Dermatological Science · doi:10.1016/0923-1811(95)00478-5 · Cited by 16
Watanabe, M., Noda, M., & Nakajin, S. (2007) · Steroids · doi:10.1016/j.steroids.2007.05.006 · Cited by 16
The Resorption and Action of Follicular Hormone rubbed into the Skin
Loeser, A. A. (1937) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1937.tb14689.x · Cited by 15
Reed, C. A., Berndtson, A. K., & Nephew, K. P. (2005) · Anti-Cancer Drugs · doi:10.1097/00001813-200506000-00012 · Cited by 14
Age-related changes of epidermal cell kinetics in the hairless mouse
Iversen, O. H., & Schjoelberg, A. R. (1984) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02890303 · Cited by 12
The effect of aging on epidermal mass in Balb/c female mice
Argyris, T. S. (1983) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(83)90088-x · Cited by 11
Ovariectomy aggravates nifedipine-induced flushing of tail skin in mice
Kai, M., Tominaga, K., Okimoto, K., Yamauchi, A., Kai, H., & Kataoka, Y. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.085 · Cited by 9
Reproduction and Longevity in the Hamster and Rat
Asdell, S. A., & Joshi, S. R. (1976) · Biology of Reproduction · doi:10.1095/biolreprod14.4.478 · Cited by 8
Gál, P., Novotný, M., Vasilenko, T., Depta, F., Šulla, I., & Tomori, Z. (2010) · Journal of Surgical Research · doi:10.1016/j.jss.2009.02.024 · Cited by 7
Swope, D. L., Castranio, T., Harrell, J. C., et al. (2002) · genesis · doi:10.1002/gene.10075 · Cited by 6
[Selective estrogen receptor modulators (SERMs)].
Matsumoto, T. (2006) · PubMed · Cited by 5
[Effect of oral estrogen treatment with estriol succinate on the skin of castrated women].
RAURAMO, L., & Punnonen, R. (1969) · PubMed · Cited by 5
Steplewski, A., Kasinskas, A., & Fertala, A. (2012) · Connective Tissue Research · doi:10.3109/03008207.2012.668252 · Cited by 4
Factors Influencing Platelet Function in Elderly Patients with Chronic Phase Thrombotic Diseases
Fukaya, S., Iwamoto, T., Kin, K., et al. (2000) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.37.619 · Cited by 3
[Effect of oral estrogens on the skin of the woman in post-menopause or after castration].
Aertgeerts, J. (1974) · PubMed · Cited by 3
Tawfik, O. W. (2005) · Cited by 1
Research works printed but not linked: 1
- Rajabi MA, Rajabi F (2007) The effect of estrogen on wound healing in rats. Pak J Med Sci 23(3):349–352
Cited by
Sorted by citations
Wound repair and regeneration: Mechanisms, signaling, and translation
Eming, S. A., Martin, P., & Tomic-Canic, M. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009337 · Cited by 3,562
Age-associated skin conditions and diseases: Current perspectives and future options
Blume-Peytavi, U., Kottner, J., Sterry, W., Hodin, M. W., Griffiths, T. W., Watson, R. E. B., Hay, R. J., & Griffiths, C. E. M. (2016) · The Gerontologist · doi:10.1093/geront/gnw003 · Cited by 221
The role of estrogen in cutaneous ageing and repair
Wilkinson, H. N., & Hardman, M. J. (2017) · Maturitas · doi:10.1016/j.maturitas.2017.06.026 · Cited by 162
Self-citationMitochondrial and sex steroid hormone crosstalk during aging
Velarde, M. C. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-2 · Cited by 96
Stem cells and aberrant signaling of molecular systems in skin aging
Peng, Y., Xuan, M., Leung, V. Y. L., & Cheng, B. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2014.10.006 · Cited by 35
Metadata
- Authors
- Emmerson, E., & Hardman, M. J.
- Affiliations
- University of Manchester (GB)
- Corresponding author
- Hardman, Matthew J.
- Venue
- Biogerontology
- Published
- 2011-03-03
- Volume
- 13
- Issue
- 1
- Pages
- 3-20
- ISSN
- 1389-5729 (ISSN-L)
- 1573-6768
- OpenAlex
- W2113848670
- Cited by
- 118
- References
- 416
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 7 · 2023: 11 · 2022: 6 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 12 · 2015: 7 · 2014: 14 · 2013: 6 · 2012: 8
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biogerontology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Keywords
- estrogen deficiency, skin aging, wound healing, menopause, hormone replacement therapy, topical estrogen, estrogen receptor, cellular senescence, telomere shortening, oxidative damage, cancer risk
- MeSH terms
- Estrogens, Female, Humans, Menopause, Wound Healing, Skin Aging
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