Cited by 118Wound Healing and TreatmentsMenopause: Health Impacts and TreatmentsEstrogen and related hormone effects

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The role of estrogen deficiency in skin ageing and wound healing

Emmerson, Elaine, Hardman, Matthew J.·2012·Biogerontology

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Abstract

The links between hormonal signalling and lifespan have been well documented in a range of model organisms. For example, in C. elegans or D. melanogaster, lifespan can be modulated by ablating germline cells, or manipulating reproductive history or pregnenolone signalling. In mammalian systems, however, hormonal contribution to longevity is less well understood. With increasing age human steroid hormone profiles change substantially, particularly following menopause in women. This article reviews recent links between steroid sex hormones and ageing, with special emphasis on the skin and wound repair. Estrogen, which substantially decreases with advancing age in both males and females, protects against multiple aspects of cellular ageing in rodent models, including oxidative damage, telomere shortening and cellular senescence. Estrogen's effects are particularly pronounced in the skin where cutaneous changes post-menopause are well documented, and can be partially reversed by classical Hormone Replacement Therapy (HRT). Our research shows that while chronological ageing has clear effects on skin wound healing, falling estrogen levels are the principle mediator of these effects. Thus, both HRT and topical estrogen replacement substantially accelerate healing in elderly humans, but are associated with unwanted deleterious effects, particularly cancer promotion. In fact, much current research effort is being invested in exploring the therapeutic potential of estrogen signalling manipulation to reverse age-associated pathology in peripheral tissues. In the case of the skin the differential targeting of estrogen receptors to promote healing in aged subjects is a real therapeutic possibility.

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Rajabi MA, Rajabi F (2007) The effect of estrogen on wound healing in rats. Pak J Med Sci 23(3):349–352

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Authors: Emmerson, E., & Hardman, M. J.
Affiliations: University of Manchester (GB)
Corresponding author: Hardman, Matthew J.
ORCID: Emmerson, Elaine
Hardman, Matthew J.
Venue: Biogerontology
Publisher: Springer Science and Business Media LLC
Published: 2011-03-03
Volume: 13
Issue: 1
Pages: 3-20
ISSN: 1389-5729 (ISSN-L)
1573-6768
DOI: 10.1007/s10522-011-9322-y
OpenAlex: W2113848670
Cited by: 118
References: 416
Citations by year: 2026: 5 · 2025: 8 · 2024: 7 · 2023: 11 · 2022: 6 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 12 · 2015: 7 · 2014: 14 · 2013: 6 · 2012: 8
FWCI: 9.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Biogerontology (publishedVersion)
PubMed (publishedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: estrogen deficiency, skin aging, wound healing, menopause, hormone replacement therapy, topical estrogen, estrogen receptor, cellular senescence, telomere shortening, oxidative damage, cancer risk
MeSH terms: Estrogens, Female, Humans, Menopause, Wound Healing, Skin Aging

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The role of estrogen deficiency in skin ageing and wound healing

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