The role of estrogen in cutaneous ageing and repair
Open accessAbstract
Combined advances in modern medical practice and increased human longevity are driving an ever-expanding elderly population. Females are particularly at risk of age-associated pathology, spending more of their lives in a post-menopausal state. Menopause, denoted by a rapid decline in serum sex steroid levels, accelerates biological ageing across the body's tissues. Post-menopause physiological changes are particularly noticeable in the skin, which loses structural architecture and becomes prone to damage. The sex steroid most widely discussed as an intrinsic contributor to skin ageing and pathological healing is 17β-estradiol (or estrogen), although many others are involved. Estrogen deficiency is detrimental to many wound-healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment widely reverses these effects. Over recent decades, many of the molecular and cellular correlates to estrogen's beneficial effect on normal skin homeostasis and wound healing have been reported. However, disparities still exist, particularly in the context of mechanistic studies investigating estrogen receptor signalling and its potential cellular effects. New molecular techniques, coupled with increased understanding of estrogen in skin biology, will provide further opportunities to develop estrogen receptor-targeted therapeutics.
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Estrogen is important to wound healing.
“estrogen is very important to wound healing27,28”
From Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells (2020) · cites this paper as [28]
Peripheral tissues produce estrogens, and estrogens play a vital role in wound healing.
“Indeed, peripheral tissues produce estrogens71, and estrogens play a vital role in wound healing27,28.”
From Platelets induce increased estrogen production through NF-κB and TGF-β1 signaling pathways in endometriotic stromal cells (2020) · cites this paper as [28]
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- Authors
- Wilkinson, H. N., & Hardman, M. J.
- Affiliations
- University of Hull (GB)
- Corresponding author
- Wilkinson, Holly N.
- Hardman, Matthew J.
- Venue
- Maturitas
- Publisher
- Elsevier BV
- Published
- 2017-09
- Volume
- 103
- Pages
- 60-64
- ISSN
- 0378-5122 (ISSN-L)
- OpenAlex
- W2648366584
- Cited by
- 162
- References
- 53
- Citations by year
- 2026: 9 · 2025: 23 · 2024: 20 · 2023: 26 · 2022: 24 · 2021: 22 · 2020: 18 · 2019: 13 · 2018: 6 · 2017: 1
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Maturitas (publishedVersion)
- PubMed (publishedVersion)
- Repository@Hull (Worktribe) (University of Hull) (acceptedVersion, other-oa)
- Repository@Hull (Worktribe) (University of Hull) (submittedVersion, cc-by-nc-nd)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- estrogen, estradiol, skin aging, wound healing, menopause, estrogen deficiency, skin homeostasis, inflammation, re-epithelialization, sex steroids, postmenopausal women
- MeSH terms
- Aging, Animals, Estrogens, Humans, Skin, Wound Healing, Skin Aging
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