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Cited by 34Escherichia coli research studiesBacterial Genetics and BiotechnologyIron Metabolism and Disorders

Genetics and environmental regulation of Shigella iron transport systems

Open access
Wyckoff, Elizabeth E., Boulette, Megan L., Payne, Shelley M.·2009·BioMetals
DOI 10.1007/s10534-008-9188-xPMC PMC3293496
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Abstract

Shigella spp. have transport systems for both ferric and ferrous iron. The iron can be taken up as free iron or complexed to a variety of carriers. All Shigella species have both the Feo and Sit systems for acquisition of ferrous iron, and all have at least one siderophore-mediated system for transport of ferric iron. Several of the transport systems, including Sit, Iuc/IutA (aerobactin synthesis and transport), Fec (ferric di-citrate uptake), and Shu (heme transport) are encoded within pathogenicity islands. The presence and the genomic locations of these islands vary considerably among the Shigella species, and even between isolates of the same species. The expression of the iron transport systems is influenced by the concentration of iron and by environmental conditions including the level of oxygen. ArcA and FNR regulate iron transport gene expression as a function of oxygen tension, with the sit and iuc promoters being highly expressed in aerobic conditions, while the feo ferrous iron transporter promoter is most active under anaerobic conditions. The effects of oxygen are also seen in infection of cultured cells by Shigella flexneri; the Sit and Iuc systems support plaque formation under aerobic conditions, whereas Feo allows plaque formation anaerobically.

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  • The presence and genomic locations of these pathogenicity islands vary considerably among Shigella species and between isolates of the same species.

    “The presence and the genomic locations of these islands vary considerably among the Shigella species and even between isolates of the same species [53, 54].”

    From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [54]

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Research works printed but not linked: 1

  1. Kehres DG Janakiraman A Slauch JM Maguire ME 2002 SitABCD is the alkaline Mn2+ transporter of Salmonella enterica serovar Typhimurium J Bacteriol 184 3159 3166 12029031 PMC135093

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Authors
Wyckoff, E. E., Boulette, M. L., & Payne, S. M.
Affiliations
The University of Texas at Austin (US)
Corresponding author
Payne, Shelley M.
ORCID
Payne, Shelley M.
Venue
BioMetals
Publisher
Springer Science and Business Media LLC
Published
2009-01-07
Volume
22
Issue
1
Pages
43-51
ISSN
  • 0966-0844 (ISSN-L)
  • 1572-8773
DOI
10.1007/s10534-008-9188-x
PMC
PMC3293496
OpenAlex
W2007503375
Cited by
34
References
34
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 3 · 2012: 1
FWCI
1.05
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • BioMetals (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Ministerstvo Školství, Mládeže a Tělovýchovy
  • Instituto Universitario de Tecnología Industrial de Asturias
  • National Institute of Allergy and Infectious Diseases (R01AI016935, AI-16935, R37AI016935)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
Shigella, iron transport systems, siderophores, aerobactin, pathogenicity islands, Arca, FNR, oxygen regulation, gene expression regulation, Shigella flexneri, plaque formation, iron acquisition
MeSH terms
Animals, Bacterial Proteins, Biological Transport, Iron, Oxygen, Shigella, Gene Expression Regulation, Bacterial, Siderophores

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