Cited by 68Bacterial Genetics and BiotechnologyEscherichia coli research studiesIron Metabolism and Disorders

Iron and Pathogenesis of Shigella: Iron Acquisition in the Intracellular Environment

Payne, Shelley M., Wyckoff, Elizabeth E., Murphy, Erin R., Oglesby, Amanda G., Boulette, Megan L., Davies, Nicola M. L.·2006·Biometals

Abstract

Shigella species are able to grow in a variety of environments, including intracellularly in host epithelial cells. Shigella have a number of different iron transport systems that contribute to their ability to grow in these diverse environments. Siderophore iron uptake systems, heme transporters, and ferric and ferrous iron transport systems are present in these bacteria, and the genes encoding some of these systems appear to have spread among the Shigella species by horizontal transmission. Iron is not only essential for growth of Shigella but also plays an important role in regulation of metabolic processes and virulence determinants in Shigella. This regulation is mediated by the repressor protein Fur and the small RNA RyhB.

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Crossref · 10.1007/s10534-005-4577-x

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38 of 38 references verified0 citation errors · 0 not checkable

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Authors
Payne, S. M., Wyckoff, E. E., Murphy, E. R., Oglesby, A. G., Boulette, M. L., & Davies, N. M. L.
Affiliations
The University of Texas at Austin (US)
Corresponding author
Payne, Shelley M.
Venue
Biometals
Published
2006-04
Volume
19
Issue
2
Pages
173-180
ISSN
  • 0966-0844 (ISSN-L)
  • 1572-8773
OpenAlex
W2001164175
Cited by
68
References
38
Citations by year
2026: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 2 · 2013: 10 · 2012: 3
FWCI
0.67
Type
journal article
Language
en
Open access
closed
Locations
  • BioMetals (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of General Medical Sciences (F32GM069312)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
Shigella, iron acquisition, intracellular growth, siderophores, heme transporters, ferrous iron transport, horizontal gene transfer, Fur repressor, bacterial virulence, host epithelial cells
MeSH terms
Bacterial Proteins, Biological Transport, Iron, Models, Biological, Mutation, Shigella, Virulence, Gene Expression Regulation, Bacterial, Siderophores, Membrane Transport Proteins

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