Iron and Pathogenesis of Shigella: Iron Acquisition in the Intracellular Environment
Abstract
Shigella species are able to grow in a variety of environments, including intracellularly in host epithelial cells. Shigella have a number of different iron transport systems that contribute to their ability to grow in these diverse environments. Siderophore iron uptake systems, heme transporters, and ferric and ferrous iron transport systems are present in these bacteria, and the genes encoding some of these systems appear to have spread among the Shigella species by horizontal transmission. Iron is not only essential for growth of Shigella but also plays an important role in regulation of metabolic processes and virulence determinants in Shigella. This regulation is mediated by the repressor protein Fur and the small RNA RyhB.
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This regulation is mediated by repressor protein Fur and small RNA RyhB.
“This regulation is mediated by the repressor protein Fur and the small RNA RyhB [52].”
From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [52]
Expression of Shigella Fe transport systems is influenced by Fe concentration and environmental conditions including oxygen level.
“The expression of the Fe transport systems is influenced by the concentration of Fe and by environmental conditions, including the level of oxygen.”
From Strategies of intracellular pathogens for obtaining iron from the environment (2015) · cites this paper as [52]
Cites
Massé, E., & Gottesman, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032066599 · Cited by 1,154 · see citing works
Bagg, A., & Neilands, J. B. (1987) · Biochemistry · doi:10.1021/bi00391a039 · Cited by 593 · see citing works
The Small RNA Regulators of Escherichia coli : Roles and Mechanisms
Gottesman, S. (2004) · Annual Review of Microbiology · doi:10.1146/annurev.micro.58.030603.123841 · Cited by 585 · see citing works
Regulation of ferric iron transport in Escherichia coli K12: Isolation of a constitutive mutant
Hantke, K. (1981) · Molecular and General Genetics MGG · doi:10.1007/bf00269672 · Cited by 563 · see citing works
Characterization of the ferrous iron uptake system of Escherichia coli
Kammler, M., Schön, C., & Hantke, K. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.19.6212-6219.1993 · Cited by 460 · see citing works
Hantke, K., Nicholson, G., Rabsch, W., & Winkelmann, G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737682100 · Cited by 359 · see citing works
Plaque formation by virulent Shigella flexneri
Oaks, E. V., Wingfield, M. E., & Formal, S. B. (1985) · Infection and Immunity · doi:10.1128/iai.48.1.124-129.1985 · Cited by 249 · see citing works
Haem iron‐transport system in enterohaemorrhagic Escherichia coli O157:H7
Torres, A. G., & Payne, S. M. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.2641628.x · Cited by 242 · see citing works
Self-citationThe structure of salmochelins: C-glucosylated enterobactins of Salmonella enterica §
Bister, B., Bischoff, D., NICHOLSON, G. J., Valdebenito, M., Schneider, K., Winkelmann, G., Hantke, K., & Süßmuth, R. D. (2004) · BioMetals · doi:10.1023/b:biom.0000029432.69418.6a · Cited by 188 · see citing works
Zhou, D., Hardt, W.-D., & Galán, J. E. (1999) · Infection and Immunity · doi:10.1128/iai.67.4.1974-1981.1999 · Cited by 182 · see citing works
SitABCD Is the Alkaline Mn<sup>2+</sup>Transporter of<i>Salmonella enterica</i>Serovar Typhimurium
Kehres, D. G., Janakiraman, A., Slauch, J. M., & Maguire, M. E. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.12.3159-3166.2002 · Cited by 177 · see citing works
Metal ion regulation of gene expression
de Lorenzo, V., Giovannini, F., Herrero, M., & Neilands, J. B. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90113-1 · Cited by 173 · see citing works
Runyen-Janecky, L. J., Reeves, S. A., Gonzales, E. G., & Payne, S. M. (2003) · Infection and Immunity · doi:10.1128/iai.71.4.1919-1928.2003 · Cited by 155 · see citing works
Self-citationVokes, S. A., Reeves, S. A., Torres, A. G., & Payne, S. M. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01448.x · Cited by 148 · see citing works
Self-citationMills, M., & Payne, S. M. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.11.3004-3009.1995 · Cited by 148 · see citing works
Self-citationA cluster of five genes specifying the aerobactin iron uptake system of plasmid ColV-K30
Carbonetti, N. H., & WILLIAMS, P. H. (1984) · Infection and Immunity · doi:10.1128/iai.46.1.7-12.1984 · Cited by 144 · see citing works
The selC‐associated SHI‐2 pathogenicity island of Shigella flexneri
Moss, J. E., Cardozo, T. J., Zychlinsky, A., & Groisman, E. A. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01449.x · Cited by 137 · see citing works
Wyckoff, E. E., Duncan, D., Torres, A. G., Mills, M., Maase, K., & Payne, S. M. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00873.x · Cited by 131 · see citing works
Self-citationLuck, S. N., Turner, S. A., Rajakumar, K., Sakellaris, H., & Adler, B. (2001) · Infection and Immunity · doi:10.1128/iai.69.10.6012-6021.2001 · Cited by 120 · see citing works
Virulence of iron transport mutants of Shigella flexneri and utilization of host iron compounds
Lawlor, K. M., Daskaleros, P. A., Robinson, R., & Payne, S. M. (1987) · Infection and Immunity · doi:10.1128/iai.55.3.594-599.1987 · Cited by 110 · see citing works
Self-citationExpression of hydroxamate and phenolate siderophores by Shigella flexneri
Payne, S. M., Niesel, D. W., Peixotto, S. S., & Lawlor, K. M. (1983) · Journal of Bacteriology · doi:10.1128/jb.155.3.949-955.1983 · Cited by 105 · see citing works
Self-citationFur regulates acid resistance in Shigella flexneri via RyhB and ydeP
Oglesby, A. G., Murphy, E. R., Iyer, V. R., & Payne, S. M. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04920.x · Cited by 90 · see citing works
Self-citationRunyen-Janecky, L. J., & Payne, S. M. (2002) · Infection and Immunity · doi:10.1128/iai.70.8.4379-4388.2002 · Cited by 87 · see citing works
Self-citationSiderophore synthesis in Klebsiella pneumoniae and Shigella sonnei during iron deficiency
Perry, R. D., & Clemente, C. L. S. (1979) · Journal of Bacteriology · doi:10.1128/jb.140.3.1129-1132.1979 · Cited by 86 · see citing works
Mills, M., & Payne, S. M. (1997) · Infection and Immunity · doi:10.1128/iai.65.12.5358-5363.1997 · Cited by 78 · see citing works
Self-citationWyckoff, E. E., Lopreato, G. F., Tipton, K. A., & Payne, S. M. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.16.5658-5664.2005 · Cited by 69 · see citing works
Phalipon, A., & Sansonetti, P. J. (2003) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v23.i56.20 · Cited by 67 · see citing works
Molecular Dissection of VirB, a Key Regulator of the Virulence Cascade of Shigella flexneri
Beloin, C., McKenna, S., & Dorman, C. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111429200 · Cited by 63 · see citing works
Purdy, G. E., & Payne, S. M. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.14.4176-4182.2001 · Cited by 57 · see citing works
Self-citationIron and virulence in <i>Shigella</i>
Payne, S. M. (1989) · Molecular Microbiology · doi:10.1111/j.1365-2958.1989.tb00281.x · Cited by 57 · see citing works
Self-citationTonB Is Required for Intracellular Growth and Virulence of Shigella dysenteriae
Reeves, S. A., Torres, A. G., & Payne, S. M. (2000) · Infection and Immunity · doi:10.1128/iai.68.11.6329-6336.2000 · Cited by 50 · see citing works
Self-citationGenetics and regulation of enterobactin genes in Shigella flexneri
Schmitt, M. P., & Payne, S. M. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.12.5579-5587.1988 · Cited by 42 · see citing works
Self-citationMarolda, C. L., Valvano, M. A., Lawlor, K. M., et al. (1987) · Microbiology · doi:10.1099/00221287-133-8-2269 · Cited by 38 · see citing works
The ShuS Protein of Shigella dysenteriae Is a Heme-Sequestering Protein That Also Binds DNA
Wilks, A. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.2250 · Cited by 36 · see citing works
Genetic analysis of the enterobactin gene cluster in Shigella flexneri
Schmitt, M. P., & Payne, S. M. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.2.816-825.1991 · Cited by 24 · see citing works
Self-citationInvasion of epithelial cells by shigellae
Hale, T. L. (1986) · Research in Microbiology · doi:10.1016/s0769-2609(86)80040-0 · Cited by 23 · see citing works
Expression of aerobactin genes by Shigella flexneri during extracellular and intracellular growth
Headley, V. L., Hong, M., Galko, M. J., & Payne, S. M. (1997) · Infection and Immunity · doi:10.1128/iai.65.2.818-821.1997 · Cited by 21 · see citing works
Self-citationPathogenic Escherichia coli, Shigella , and Salmonella
Payne, S. M., & Mey, A. R. (2014) · ASM Press eBooks · doi:10.1128/9781555816544.ch14 · Cited by 16 · see citing works
Self-citation
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Probiotic Bacteria Reduce Salmonella Typhimurium Intestinal Colonization by Competing for Iron
Deriu, E., Liu, J. Z., Pezeshki, M., Edwards, R. A., Ochoa, R. J., Contreras, H., Libby, S. J., Fang, F. C., & Raffatellu, M. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.06.007 · Cited by 550 · see citing works
Functional specialization within the Fur family of metalloregulators
Lee, J.-W., & Helmann, J. D. (2007) · BioMetals · doi:10.1007/s10534-006-9070-7 · Cited by 432 · see citing works
Diverging roles of bacterial siderophores during infection
Holden, V. I., & Bachman, M. A. (2015) · Metallomics · doi:10.1039/c4mt00333k · Cited by 274 · see citing works
Smith, A. D., & Wilks, A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.633495 · Cited by 83 · see citing works
Strategies of intracellular pathogens for obtaining iron from the environment
Leon-Sicairos, N., Reyes-Cortes, R., Guadrón-Llanos, A. M., Madueña-Molina, J., Leon-Sicairos, C., & Canizalez-Román, A. (2015) · BioMed Research International · doi:10.1155/2015/476534 · Cited by 51 · see citing works
“This regulation is mediated by the repressor protein Fur and the small RNA RyhB [52].”
BackgroundInfluentialGenetics and environmental regulation of Shigella iron transport systems
Wyckoff, E. E., Boulette, M. L., & Payne, S. M. (2009) · BioMetals · doi:10.1007/s10534-008-9188-x · Cited by 34 · see citing works
Self-citation
- Authors
- Payne, S. M., Wyckoff, E. E., Murphy, E. R., Oglesby, A. G., Boulette, M. L., & Davies, N. M. L.
- Affiliations
- The University of Texas at Austin (US)
- Corresponding author
- Payne, Shelley M.
- Venue
- Biometals
- Published
- 2006-04
- Volume
- 19
- Issue
- 2
- Pages
- 173-180
- ISSN
- 0966-0844 (ISSN-L)
- 1572-8773
- OpenAlex
- W2001164175
- Cited by
- 68
- References
- 38
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 2 · 2013: 10 · 2012: 3
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- BioMetals (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (F32GM069312)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- Shigella, iron acquisition, intracellular growth, siderophores, heme transporters, ferrous iron transport, horizontal gene transfer, Fur repressor, bacterial virulence, host epithelial cells
- MeSH terms
- Bacterial Proteins, Biological Transport, Iron, Models, Biological, Mutation, Shigella, Virulence, Gene Expression Regulation, Bacterial, Siderophores, Membrane Transport Proteins
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