The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer
Open accessAbstract
SummaryThis study is the first large prospective RCT of sentinel node biopsy (SNB) compared with standard axillary treatment (level I-III axillary lymph node dissection or four node sampling), which includes comprehensive and repeated quality of life (QOL) assessments over 18 months. Patients (n=829) completed the Functional Assessment of Cancer Therapy – Breast (FACT-B+4) and the Spielberger State/Trait Anxiety Inventory (STAI) at baseline (pre-surgery) and at 1, 3, 6, 12, and 18 months post-surgery. There were significant differences between treatment groups favouring the SNB group throughout the 18 months assessment. Patients in the standard treatment group showed a greater decline in Trial Outcome Index (TOI) scores (physical well-being, functional well-being and breast cancer concerns subscales in FACT-B+4) and recovered more slowly than patients in the SNB group (p<0.01). The change in total FACT-B+4 scores (measuring global QOL) closely resembled the TOI results. 18 months post-surgery approximately twice as many patients in the standard group compared with the SNB group reported substantial arm swelling (14% versus 7%) (p=0.002) or numbness (19% versus 8.7%) (p<0.001). Despite the uncertainty about undergoing a relatively new procedure and the possible need for further surgery, there was no evidence of increased anxiety amongst patients randomised to SNB (p>0.05). For 6 months post-surgery younger patients reported less favourable QOL scores (p<0.001) and greater levels of anxiety (p<0.01). In view of the benefits regarding arm functioning and quality of life, the data from this randomised study support the use of SNB in patients with clinically node negative breast cancer.
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Cites
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Cited by
Krag, D. N., Anderson, S. J., Julian, T. B., Brown, A. M., Harlow, S. P., Costantino, J. P., Ashikaga, T., Weaver, D. L., Mamounas, E. P., Jalovec, L. M., et al. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70207-2 · Cited by 1,920
Lymphedema following breast cancer treatment and impact on quality of life: A review
Taghian, N. R., Miller, C. L., Jammallo, L. S., O’Toole, J., & Skolny, M. N. (2014) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2014.06.004 · Cited by 333
on behalf of the Recovery Study Group, Bruce, J., Thornton, A. J., Scott, N. W., Marfizo, S., Powell, R., Johnston, M., Wells, M., Heys, S. D., & Thompson, A. M. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.341 · Cited by 121
Metadata
- Authors
- Fleissig, A., Fallowfield, L. J., Langridge, C. I., Johnson, L., Newcombe, R. G., Dixon, J. M., Kissin, M., & Mansel, R. E.
- Venue
- Breast Cancer Research and Treatment
- Published
- 2005-09-15
- Volume
- 95
- Issue
- 3
- Pages
- 279-293
- ISSN
- 0167-6806 (ISSN-L)
- 1573-7217
- OpenAlex
- W2012202415
- Cited by
- 494
- References
- 33
- FWCI
- 6.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Fleissig, A., Fallowfield, L. J., Langridge, C. I., Johnson, L., Newcombe, R. G., Dixon, J. M., Kissin, M., & Mansel, R. E. (2006). Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer. Breast Cancer Research and Treatment. https://doi.org/10.1007/s10549-005-9025-7
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