An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

Nonparametric Estimation from Incomplete Observations

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Nonparametric Estimation from Incomplete Observations

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A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer

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Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer

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Gene Expression and Benefit of Chemotherapy in Women With Node-Negative, Estrogen Receptor–Positive Breast Cancer

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American Society of Clinical Oncology 2007 Update of Recommendations for the Use of Tumor Markers in Breast Cancer

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The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

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Gene Expression Profiling in Breast Cancer: Understanding the Molecular Basis of Histologic Grade To Improve Prognosis

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Genes that mediate breast cancer metastasis to the brain

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RNA-Sequencing Reveals Heat Shock 70-kDa Protein 6 (HSPA6) as a Novel Thymoquinone-Upregulated Gene That Inhibits Growth, Migration, and Invasion of Triple-Negative Breast Cancer Cells

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Identification of a six‐microRNA signature as a potential diagnostic biomarker in breast cancer tissues

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Targeting HIF1-alpha/miR-326/ITGA5 axis potentiates chemotherapy response in triple-negative breast cancer

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Gene expression predicts dormant metastatic breast cancer cell phenotype

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Statistics and network-based approaches to identify molecular mechanisms that drive the progression of breast cancer

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Targeted H3R26 Deimination Specifically Facilitates Estrogen Receptor Binding by Modifying Nucleosome Structure

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Potential prognostic biomarker CD73 regulates epidermal growth factor receptor expression in human breast cancer

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Regulation of Cancer Cell Behavior by the Small GTPase Rab13

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HOXC10 Expression Supports the Development of Chemotherapy Resistance by Fine Tuning DNA Repair in Breast Cancer Cells

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S100B expression in breast cancer as a predictive marker for cancer metastasis

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The mRNA Expression Signature and Prognostic Analysis of Multiple Fatty Acid Metabolic Enzymes in Clear Cell Renal Cell Carcinoma

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HDAC5-mediated deacetylation and nuclear localisation of SOX9 is critical for tamoxifen resistance in breast cancer

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Single-cell RNA sequencing of immune cells in gastric cancer patients

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Guizhi Fuling Decoction inhibiting the PI3K and MAPK pathways in breast cancer cells revealed by HTS 2 technology and systems pharmacology

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Prognostic Values of TIM-3 Expression in Patients With Solid Tumors: A Meta-Analysis and Database Evaluation

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Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis

Tsao, L.-C., Crosby, E. J., Trotter, T. N., Wei, J.-P., Wang, T., Yang, X. Y., Summers, A. N., Lei, G., Rabiola, C. A., Chodosh, L. A., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.155636 · Cited by 57

Hippo/YAP signaling choreographs the tumor immune microenvironment to promote triple negative breast cancer progression via TAZ/IL-34 axis

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The Impact of PIK3R1 Mutations and Insulin–PI3K–Glycolytic Pathway Regulation in Prostate Cancer

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A single N6-methyladenosine site regulates lncRNA HOTAIR function in breast cancer cells

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Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer*

Young, C. D., Zimmerman, L. J., Hoshino, D., Formisano, L., Hanker, A. B., Gatza, M. L., Morrison, M. M., Moore, P. D., Whitwell, C. A., Dave, B., et al. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.049783 · Cited by 53

Junctional adhesion molecule-A is co-expressed with HER2 in breast tumors and acts as a novel regulator of HER2 protein degradation and signaling

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Cancer-associated fibroblasts induce trastuzumab resistance in HER2 positive breast cancer cells

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PROGmiR: a tool for identifying prognostic miRNA biomarkers in multiple cancers using publicly available data

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ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion

Dang, T. T., Westcott, J. M., Maine, E. A., Kanchwala, M., Xing, C., & Pearson, G. W. (2016) · Oncotarget · doi:10.18632/oncotarget.8696 · Cited by 53

Stathmin1 expression is associated with aggressive phenotypes and cancer stem cell marker expression in breast cancer patients

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Proteasome 26S subunit PSMD1 regulates breast cancer cell growth through p53 protein degradation

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YAP1 inhibition radiosensitizes triple negative breast cancer cells by targeting the DNA damage response and cell survival pathways

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The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor

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EGFL6 promotes breast cancer by simultaneously enhancing cancer cell metastasis and stimulating tumor angiogenesis

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Transcriptional expressions of Chromobox 1/2/3/6/8 as independent indicators for survivals in hepatocellular carcinoma patients

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Transcriptomic analyses identify key differentially expressed genes and clinical outcomes between triple-negative and non-triple-negative breast cancer

Chen, B., Tang, H., Chen, X., Zhang, G., Wang, Y., Xie, X., & Liao, N. (2018) · Cancer Management and Research · doi:10.2147/cmar.s187151 · Cited by 53

Stress hormone-mediated acceleration of breast cancer metastasis is halted by inhibition of nitric oxide synthase

Flaherty, R. L., Intabli, H., Falcinelli, M., Bucca, G., Hesketh, A. R., Patel, B. A., Allen, M. C., Smith, C. P. S., & Flint, M. S. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.05.027 · Cited by 53

GREM1 is associated with metastasis and predicts poor prognosis in ER-negative breast cancer patients

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FZD5 contributes to TNBC proliferation, DNA damage repair and stemness

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ASB13 inhibits breast cancer metastasis through promoting SNAI2 degradation and relieving its transcriptional repression of YAPPreprint

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Expression of ID4 protein in breast cancer cells induces reprogramming of tumour-associated macrophages

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Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy

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DNA methylation biomarkers for noninvasive detection of triple‐negative breast cancer using liquid biopsy

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The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway

Salah, Z., Itzhaki, E., & Aqeilan, R. I. (2014) · Oncotarget · doi:10.18632/oncotarget.2540 · Cited by 52

Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors

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The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin

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Weighted gene correlation network analysis identifies RSAD2, HERC5, and CCL8 as prognostic candidates for breast cancer

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Systemic Delivery of Aptamer-Conjugated XBP1 siRNA Nanoparticles for Efficient Suppression of HER2+ Breast Cancer

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Prognostic implications of the expression levels of different immunoglobulin heavy chain-encoding RNAs in early breast cancer

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Overexpression of GPX3, a potential biomarker for diagnosis and prognosis of breast cancer, inhibits progression of breast cancer cells in vitro

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The IL-17B-IL-17 receptor B pathway promotes resistance to paclitaxel in breast tumors through activation of the ERK1/2 pathway

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Integration of Breast Cancer Secretomes with Clinical Data Elucidates Potential Serum Markers for Disease Detection, Diagnosis, and Prognosis

Ziegler, Y., Moresco, J. J., Yates, J. R., & Nardulli, A. M. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158296 · Cited by 55

Prognostic and Genomic Analysis of Proteasome 20S Subunit Alpha (PSMA) Family Members in Breast Cancer

Chiao, C.-C., Liu, Y.-H., Phan, N. N., Ton, N. T. A., Ta, H. D. K., Anuraga, G., Xuan, D. T. M., Fitriani, F., Hermanto, E. M. P., Athoillah, M., et al. (2021) · Diagnostics · doi:10.3390/diagnostics11122220 · Cited by 51

Prognostic relevance of carbonic anhydrase IX expression is distinct in various subtypes of breast cancer and its silencing suppresses self-renewal capacity of breast cancer cells

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Integrated Quantitative Analysis of the Phosphoproteome and Transcriptome in Tamoxifen-resistant Breast Cancer

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Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis

Pickup, M. W., Hover, L. D., Guo, Y. H., Gorska, A. E., Chytil, A. M., Novitskiy, S. V., Moses, H. L., & Owens, P. (2015) · Oncotarget · doi:10.18632/oncotarget.4413 · Cited by 51

p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells

Zhuang, T., Zhu, J., Li, Z., Lorent, J., Zhao, C., Dahlman‐Wright, K., & Strömblad, S. (2015) · Oncotarget · doi:10.18632/oncotarget.6081 · Cited by 51

G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program

Yim, C. Y., Sekula, D., Hever-Jardine, M. P., Liu, X., Warzecha, J. M., Tam, J. K. V., Freemantle, S. J., Dmitrovsky, E., & Spinella, M. J. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2265 · Cited by 51

SPEN, a new player in primary cilia formation and cell migration in breast cancer

Légaré, S., Chabot, C., & Basik, M. (2017) · Breast Cancer Research · doi:10.1186/s13058-017-0897-3 · Cited by 49

t-Darpp Activates IGF-1R Signaling to Regulate Glucose Metabolism in Trastuzumab-Resistant Breast Cancer Cells

Lenz, G., Hamilton, A., Geng, S., Hong, T., Kalkum, M., Momand, J. A., Kane, S. E., & Huss, J. M. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-0824 · Cited by 51

GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers

Rasheed, S. A. K., Leong, H. S., Lakshmanan, M., Raju, A., Dadlani, D., Chong, F.-T., Shannon, N. B., Rajarethinam, R., Skanthakumar, T., Tan, E. Y., et al. (2017) · Oncogene · doi:10.1038/s41388-017-0038-6 · Cited by 51

Functional Isolation of Tumor-Initiating Cells using Microfluidic-Based Migration Identifies Phosphatidylserine Decarboxylase as a Key Regulator

Chen, Y., Humphries, B. A., Brien, R., Gibbons, A. E., Chen, Y., Qyli, T., Haley, H. R., Pirone, M., Chiang, B., Xiao, A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-18610-5 · Cited by 53

LW106, a novel indoleamine 2,3‐dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma‐immune crosstalk and cancer stem cell enrichment in tumour micro‐environment

Fu, R., Zhang, Y., Li, H., Lv, W., Zhao, L., Guo, Q., Lu, T., Weiss, S. J., Li, Z., & Wu, Z. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14351 · Cited by 51

NLRX1 regulates TNF-α-induced mitochondria-lysosomal crosstalk to maintain the invasive and metastatic potential of breast cancer cells

Singh, K., Roy, M., Prajapati, P., Lipatova, A. V., Sripada, L., Gohel, D., Singh, A., Mane, M., Godbole, M. M., Chumakov, P. M., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.02.018 · Cited by 56

A Multigene Assay Determines Risk of Recurrence in Patients with Triple-Negative Breast Cancer

Stewart, R. L., Updike, K. L., Factor, R. E., Henry, N. L., Boucher, K. M., Bernard, P. S., & Varley, K. E. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3014 · Cited by 53

The tumor cell‐secreted matricellular protein WISP1 drives pro‐metastatic collagen linearization

Jia, H., Janjanam, J., Wu, S. C., Wang, R., Pano, G., Célestine, M., Martinot, O., Breeze‐Jones, H., Clayton, G., Garcin, C., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018101302 · Cited by 56

Prognostic value of prostaglandin I2 synthase and its correlation with tumor-infiltrating immune cells in lung cancer, ovarian cancer, and gastric cancer

Dai, D., Chen, B., Feng, Y., Wang, W., Jiang, Y., Huang, H., & Liu, J. (2020) · Aging · doi:10.18632/aging.103235 · Cited by 50

G9a regulates tumorigenicity and stemness through genome-wide DNA methylation reprogramming in non-small cell lung cancer

Pangeni, R. P., Yang, L., Zhang, K., Wang, J., Li, W., Guo, C., Yun, X., Sun, T., Wang, J., & Raz, D. J. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-00879-5 · Cited by 52

EI24 regulates epithelial-to-mesenchymal transition and tumor progression by suppressing TRAF2-mediated NF-κB activity

Choi, J., Devkota, S., Sung, Y. H., & Lee, H. (2013) · Oncotarget · doi:10.18632/oncotarget.1434 · Cited by 51

Machine learning analysis identifies genes differentiating triple negative breast cancers

Kothari, C., Osseni, M. A., Agbo, L., Ouellette, G., Déraspe, M., Laviolette, F., Corbeil, J., Lambert, J., Diorio, C., & Durocher, F. (2020) · Scientific Reports · doi:10.1038/s41598-020-67525-1 · Cited by 50

ERRβ signalling through FST and BCAS2 inhibits cellular proliferation in breast cancer cells

Sengupta, D., Bhargava, D. K., Dixit, A., Sahoo, B. S., Biswas, S., Biswas, G., & Mishra, S. K. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.53 · Cited by 50

Fatty acid and phospholipid biosynthetic pathways are regulated throughout mammary epithelial cell differentiation and correlate to breast cancer survival

Dória, M. L., Ribeiro, A. S., Wang, J., Cotrim, C. Z., Domingues, P. M., Williams, C., Domingues, M. R., & Helguero, L. A. (2014) · The FASEB Journal · doi:10.1096/fj.14-249672 · Cited by 50

Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer

Manteghi, S., Gingras, M., Kharitidi, D., Galarneau, L., Marques, M., Yan, M., Cencic, R., Robert, F., Paquet, M., Witcher, M., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.04.076 · Cited by 53

Suppression of breast cancer metastasis through the inactivation of ADP-ribosylation factor 1

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Elevated PRC1 in gastric carcinoma exerts oncogenic function and is targeted by piperlongumine in a p53‐dependent manner

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Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94

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Prominent Oncogenic Roles of EVI1 in Breast Carcinoma

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The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer

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The E3 Ubiquitin Ligase HectD1 Suppresses EMT and Metastasis by Targeting the +TIP ACF7 for Degradation

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Arsenic-induced sub-lethal stress reprograms human bronchial epithelial cells to CD61¯ cancer stem cells

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The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis

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